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Details

Stereochemistry ABSOLUTE
Molecular Formula C23H23ClFNO5
Molecular Weight 447.884
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ELVITEGRAVIR

SMILES

COC1=C(CC2=CC=CC(Cl)=C2F)C=C3C(=O)C(=CN([C@H](CO)C(C)C)C3=C1)C(O)=O

InChI

InChIKey=JUZYLCPPVHEVSV-LJQANCHMSA-N
InChI=1S/C23H23ClFNO5/c1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25/h4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30)/t19-/m1/s1

HIDE SMILES / InChI
Molecular Formula C23H23ClFNO5
Molecular Weight 447.884
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 18:04:58 UTC 2023
Edited
by admin
on Sat Dec 16 18:04:58 UTC 2023
Record UNII
4GDQ854U53
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ELVITEGRAVIR
DASH   INN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN   INN  
Official Name English
ELVITEGRAVIR COMPONENT OF STRIBILD
Brand Name English
GS-9137
Code English
ELVITEGRAVIR [VANDF]
Common Name English
Elvitegravir [WHO-DD]
Common Name English
ELVITEGRAVIR [MI]
Common Name English
JTK-303
Code English
3-QUINOLINECARBOXYLIC ACID, 6-((3-CHLORO-2-FLUOROPHENYL)METHYL)-1,4-DIHYDRO-1-((1S)-1-(HYDROXYMETHYL)-2-METHYLPROPYL)-7-METHOXY-4-OXO-
Common Name English
ELVITEGRAVIR COMPONENT OF VITEKTA
Brand Name English
ELVITEGRAVIR COMPONENT OF GENVOYA
Brand Name English
ELVITEGRAVIR [USAN]
Common Name English
6-(3-CHLORO-2-FLUOROBENZYL)-1-((1S)-1-(HYDROXYMETHYL)-2-METHYLPROPYL)-7-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
Systematic Name English
elvitegravir [INN]
Common Name English
VITEKTA COMPONENT ELVITEGRAVIR
Brand Name English
ELVITEGRAVIR [ORANGE BOOK]
Common Name English
STRIBILD COMPONENT ELVITEGRAVIR
Brand Name English
ELVITEGRAVIR [MART.]
Common Name English
ELVITEGRAVIR [JAN]
Common Name English
6-(3-Chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Systematic Name English
Classification Tree Code System Code
WHO-VATC QJ05AX11
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
WHO-VATC QJ05AR09
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
WHO-ATC J05AR09
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
WHO-ATC J05AX11
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
WHO-ATC J05AR18
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
NDF-RT N0000175887
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
NCI_THESAURUS C281
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
LIVERTOX NBK547911
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
EMA ASSESSMENT REPORTS GENVOYA (AUTHORIZED: HIV INFECTIONS)
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
EMA ASSESSMENT REPORTS VITEKTA (AUTHORIZED: HIV INFECTIONS)
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
Code System Code Type Description
CHEBI
72289
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
INN
8871
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
USAN
SS-98
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
WIKIPEDIA
Elvitegravir
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
NDF-RT
N0000185507
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY Cytochrome P450 2C9 Inducers [MoA]
PUBCHEM
5277135
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
EVMPD
SUB69759
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
FDA UNII
4GDQ854U53
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
SMS_ID
100000135179
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
CAS
697761-98-1
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
NCI_THESAURUS
C76493
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
RXCUI
1306286
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY RxNorm
DRUG CENTRAL
4300
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
DRUG BANK
DB09101
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
MERCK INDEX
m4880
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY Merck Index
EPA CompTox
DTXSID10102165
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
LACTMED
Elvitegravir
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
ChEMBL
CHEMBL204656
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
DAILYMED
4GDQ854U53
Created by admin on Sat Dec 16 18:04:58 UTC 2023 , Edited by admin on Sat Dec 16 18:04:58 UTC 2023
PRIMARY
Related Record Type Details
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
MAJOR
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INTEGRASE
TARGET -> INHIBITOR
INHIBITOR
IC50
Related Record Type Details
Structure of ELVITEGRAVIR ACYL GLUCURONIDE
METABOLITE LESS ACTIVE -> PARENT
produced by uridine diphosphate glucuronoslytransferase UGT 1A1/3
Structure of P-HYDROXY ELVITEGRAVIR
METABOLITE LESS ACTIVE -> PARENT
Elvitegravir is also metabolized via CYP3A to hydroxy-EVG [metabolite M1]
Related Record Type Details
Structure of ELVITEGRAVIR
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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