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Details

Stereochemistry RACEMIC
Molecular Formula C20H24N2O6
Molecular Weight 388.4144
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NISOLDIPINE

SMILES

COC(=O)C1=C(C)NC(C)=C(C1C2=C(C=CC=C2)[N+]([O-])=O)C(=O)OCC(C)C

InChI

InChIKey=VKQFCGNPDRICFG-UHFFFAOYSA-N
InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3

HIDE SMILES / InChI
Molecular Formula C20H24N2O6
Molecular Weight 388.4144
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:51:42 UTC 2023
Edited
by admin
on Sat Dec 16 17:51:42 UTC 2023
Record UNII
4I8HAB65SZ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NISOLDIPINE
INN   JAN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN   INN  
Official Name English
NISOLDIPINE [MART.]
Common Name English
3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-, METHYL 2-METHYLPROPYL ESTER, (±)-
Common Name English
NISOLDIPINE [ORANGE BOOK]
Common Name English
3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-, 3-METHYL 5-(2-METHYLPROPYL) ESTER
Systematic Name English
NISOLDIPIN
Brand Name English
BAYMYCARD
Brand Name English
SULAR
Brand Name English
NISOCOR
Brand Name English
(±)-NISOLDIPINE
Common Name English
NISOLDIPINE [JAN]
Common Name English
nisoldipine [INN]
Common Name English
NISOLDIPINE [USAN]
Common Name English
METHYL 2-METHYLPROPYL-1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE, DL-
Common Name English
(±)-BAY-K-5552
Common Name English
NISOLDIPINE [VANDF]
Common Name English
NSC-759106
Code English
NISOLDIPINE (STN)
Brand Name English
NISOLDIPINE [USP-RS]
Common Name English
Nisoldipine [WHO-DD]
Common Name English
NISOLDIPINE [MI]
Common Name English
BAY-K-5552
Code English
GEOMATRIX 16E
Brand Name English
BAY K 5552
Code English
3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-, METHYL 2-METHYLPROPYL ESTER
Common Name English
Classification Tree Code System Code
WHO-VATC QC08CA07
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
NCI_THESAURUS C333
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
NDF-RT N0000175421
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
WHO-ATC C08CA07
Created by admin on Sat Dec 16 17:51:42 UTC 2023 , Edited by admin on Sat Dec 16 17:51:42 UTC 2023
LIVERTOX NBK548364
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
Code System Code Type Description
MERCK INDEX
m7921
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
PRIMARY Merck Index
SMS_ID
100000092490
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
PRIMARY
ECHA (EC/EINECS)
264-407-7
Created by admin on Sat Dec 16 17:51:42 UTC 2023 , Edited by admin on Sat Dec 16 17:51:42 UTC 2023
PRIMARY
CHEBI
7577
Created by admin on Sat Dec 16 17:51:42 UTC 2023 , Edited by admin on Sat Dec 16 17:51:42 UTC 2023
PRIMARY
MESH
D015737
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
PRIMARY
LACTMED
Nisoldipine
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
PRIMARY
INN
4753
Created by admin on Sat Dec 16 17:51:42 UTC 2023 , Edited by admin on Sat Dec 16 17:51:42 UTC 2023
PRIMARY
NDF-RT
N0000178477
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
PRIMARY Decreased Blood Pressure [PE]
DRUG BANK
DB00401
Created by admin on Sat Dec 16 17:51:42 UTC 2023 , Edited by admin on Sat Dec 16 17:51:42 UTC 2023
PRIMARY
ChEMBL
CHEMBL1726
Created by admin on Sat Dec 16 17:51:42 UTC 2023 , Edited by admin on Sat Dec 16 17:51:42 UTC 2023
PRIMARY
EVMPD
SUB09307MIG
Created by admin on Sat Dec 16 17:51:42 UTC 2023 , Edited by admin on Sat Dec 16 17:51:42 UTC 2023
PRIMARY
EPA CompTox
DTXSID0023371
Created by admin on Sat Dec 16 17:51:42 UTC 2023 , Edited by admin on Sat Dec 16 17:51:42 UTC 2023
PRIMARY
RS_ITEM_NUM
1463927
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
PRIMARY
NSC
759106
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
PRIMARY
RXCUI
7435
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
PRIMARY RxNorm
DRUG CENTRAL
1942
Created by admin on Sat Dec 16 17:51:42 UTC 2023 , Edited by admin on Sat Dec 16 17:51:42 UTC 2023
PRIMARY
IUPHAR
2524
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
PRIMARY
FDA UNII
4I8HAB65SZ
Created by admin on Sat Dec 16 17:51:42 UTC 2023 , Edited by admin on Sat Dec 16 17:51:42 UTC 2023
PRIMARY
NCI_THESAURUS
C29291
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
PRIMARY
PUBCHEM
4499
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
PRIMARY
WIKIPEDIA
NISOLDIPINE
Created by admin on Sat Dec 16 17:51:43 UTC 2023 , Edited by admin on Sat Dec 16 17:51:43 UTC 2023
PRIMARY
DAILYMED
4I8HAB65SZ
Created by admin on Sat Dec 16 17:51:42 UTC 2023 , Edited by admin on Sat Dec 16 17:51:42 UTC 2023
PRIMARY
CAS
63675-72-9
Created by admin on Sat Dec 16 17:51:42 UTC 2023 , Edited by admin on Sat Dec 16 17:51:42 UTC 2023
PRIMARY
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DEGRADENT -> PARENT
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PLASMA
Structure of 5-((2-HYDROXY-2-METHYLPROPOXY)CARBONYL)-2,6-DIMETHYL-4-(2-NITROPHENYL)NICOTINIC ACID
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Dehydrogenation step is catalyzed by the cytochrome P450 (CYP) 3A4 enzyme
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Although M9 showed small pharmacological activity ? qualitatively similar to nisoldipine ? in animal models, it does not contribute significantly to the haemodynamic effects of the drug in humans.
PLASMA
Structure of 5-((2-HYDROXY-2-METHYLPROPOXY)CARBONYL)-2-(HYDROXYMETHYL)-6-METHYL-4-(2-NITROPHENYL)NICOTINIC ACID
METABOLITE -> PARENT
Dehydrogenation step is catalyzed by the cytochrome P450 (CYP) 3A4 enzyme
PLASMA; URINE
Structure of DEHYDRO NISOLDIPINE
METABOLITE -> PARENT
PLASMA
Structure of DESISOBUTYL NISOLDIPINE
METABOLITE -> PARENT
URINE
Structure of DESMETHYL DEHYDRONIFEDIPINE
METABOLITE -> PARENT
Dehydrogenation step is catalysed by the cytochrome P450 (CYP) 3A4 enzyme
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Related Record Type Details
Structure of NISOLDIPINE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Excretion PHARMACOKINETIC
Structure of NISOLDIPINE
Urine
BIOLOGICAL
Biological Half-life PHARMACOKINETIC
Structure of NISOLDIPINE
NIH
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