RETAPAMULIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C30H47NO4S
Molecular Weight	517.763
Optical Activity	UNSPECIFIED
Defined Stereocenters	11 / 11
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of RETAPAMULIN

Structure Search

SMILES

[H][C@@]12C(=O)CC[C@]13CC[C@@H](C)[C@@]2(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]3C)OC(=O)CS[C@H]4C[C@@H]5CC[C@H](C4)N5C

InChI

InChIKey=STZYTFJPGGDRJD-NHUWBDDWSA-N

InChI=1S/C30H47NO4S/c1-7-28(4)16-24(35-25(33)17-36-22-14-20-8-9-21(15-22)31(20)6)29(5)18(2)10-12-30(19(3)27(28)34)13-11-23(32)26(29)30/h7,18-22,24,26-27,34H,1,8-17H2,2-6H3/t18-,19+,20-,21+,22-,24-,26+,27+,28-,29+,30+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C30H47NO4S
Molecular Weight	517.763
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	11 / 11
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:45:10 UTC 2023` Edited by `admin` on `Fri Dec 15 15:45:10 UTC 2023`
Record UNII	4MG6O8991R
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

RETAPAMULIN

Official Name

English

retapamulin [INN]

Common Name

English

RETAPAMULIN [MI]

Common Name

English

ALTABAX

Brand Name

English

RETAPAMULIN [EMA EPAR]

Common Name

English

SB275833

Code

English

RETAPAMULIN [MART.]

Common Name

English

(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-Ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propano-3aH-cyclopenta[8]annulen-8-yl [[(1R,3S,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]sulfanyl]acetate

Common Name

English

SB-275833

Code

English

RETAPAMULIN [ORANGE BOOK]

Common Name

English

RETAPAMULIN [USAN]

Common Name

English

RETAPAMULIN [VANDF]

Common Name

English

ALTARGO

Brand Name

English

Retapamulin [WHO-DD]

Common Name

English

ACETIC ACID, (((3-EXO)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL)THIO)-, (3AS,4R,5S,6S,8R,9R,9AR,10R)-6-ETHENYLDECAHYDRO-5-HYDROXY-4,6,9,10-TETRAMETHYL-1-OXO-3A,9-PROPANO-3AH-CYCLOPENTACYCLOOCTEN-8-YL ESTER

Common Name

English

NSC-759885

Code

English

Classification Tree Code System Code

WHO-ATC

D06AX13

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

WHO-VATC

QD06AX13

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

NDF-RT

N0000175434

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

NDF-RT

N0000175433

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

NCI_THESAURUS

C258

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

EMA ASSESSMENT REPORTS

ALTARGO(AUTHORIZED IMPETIGO)

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

Code System Code Type Description

FDA UNII

4MG6O8991R

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

WIKIPEDIA

RETAPAMULIN

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

EPA CompTox

DTXSID00870265

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

INN

8494

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

CAS

224452-66-8

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

DRUG BANK

DB01256

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

MESH

C508887

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

EVMPD

SUB25391

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

RXCUI

642274

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

RxNorm

SMS_ID

100000089366

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

MERCK INDEX

m9551

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

Merck Index

USAN

PP-62

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

NSC

759885

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

NCI_THESAURUS

C61924

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

DAILYMED

4MG6O8991R

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

ChEMBL

CHEMBL409542

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

DRUG CENTRAL

2371

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

LACTMED

Retapamulin

Created by admin on Fri Dec 15 15:45:10 UTC 2023 , Edited by admin on Fri Dec 15 15:45:10 UTC 2023

PRIMARY

Related Record Type Details


					805SU96HKF

CYTOCHROME P450 3A5

METABOLIC ENZYME -> SUBSTRATE

Amount:


					LJ2LP0YL98

STREPTOCOCCUS PYOGENES

TARGET ORGANISM->INHIBITOR

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

MAJOR

Amount:


					O478WX4004

STAPHYLOCOCCUS AUREUS

TARGET ORGANISM->INHIBITOR

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE

Amount:


					8E4LAA4357

CYTOCHROME P450 2D6

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

MINOR

Amount:


					L0423Z5LDW

CYTOCHROME P450 2C8

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

MINOR

Amount:

Related Record Type Details


					SK6ZRR7EZJ

(3AR,4R,5S,6S,8R,9R,9AS,10R,12R)-5,12-DIHYDROXY-4,6,9,10-TETRAMETHYL-1-OXO-6-VINYLDECAHYDRO-3A,9-PROPANOCYCLOPENTA(8)ANNULEN-8-YL 2-(((1R,3S,5S)-8-AZABICYCLO(3.2.1)OCTAN-3-YL)THIO)ACETATE

METABOLITE -> PARENT

Amount:


					TA8TAD3U9X

(2S,3AR,4R,5S,6S,8R,9R,9AS,10R,12R)-2,5,12-TRIHYDROXY-4,6,9,10-TETRAMETHYL-1-OXO-6-VINYLDECAHYDRO-3A,9-PROPANOCYCLOPENTA(8)ANNULEN-8-YL 2-(((1R,3S,5S)-8-METHYL-8-AZABICYCLO(3.2.1)OCTAN-3-YL)THIO)ACETATE

METABOLITE -> PARENT

Amount:


					A83V5VJ3DF

(3AR,4R,5R,7S,8S,9R,9AS,12R)-8-HYDROXY-4,7,9,12-TETRAMETHYL-3-OXO-7-VINYLDECAHYDRO-4,9A-PROPANOCYCLOPENTA(8)ANNULEN-5-YL 2-((R)-((1R,3S,5S)-8-METHYL-8-AZABICYCLO(3.2.1)OCTAN-3-YL)SULFINYL)ACETATE

METABOLITE -> PARENT

Amount:


					M3F5WC3LNS

N-DEMETHYL-RETAPAMULIN

METABOLITE -> PARENT

Amount:


					CA38KL4ZKP

(3AR,4R,5R,7S,8S,9R,9AS,12R)-8-HYDROXY-4,7,9,12-TETRAMETHYL-3-OXO-7-VINYLDECAHYDRO-4,9A-PROPANOCYCLOPENTA(8)ANNULEN-5-YL 2-(((1R,3S,5S)-8-AZABICYCLO(3.2.1)OCTAN-3-YL)THIO)ACETATE

METABOLITE -> PARENT

Amount:


					AXJ4XV4A66

(2S,3AR,4R,5R,7S,8S,9R,9AS,12R)-2,8-DIHYDROXY-4,7,9,12-TETRAMETHYL-3-OXO-7-VINYLDECAHYDRO-4,9A-PROPANOCYCLOPENTA(8)ANNULEN-5-YL 2-(((1R,3S,5S)-8-METHYL-8-AZABICYCLO(3.2.1)OCTAN-3-YL)THIO)ACETATE

METABOLITE -> PARENT

Amount:

Related Record Type Details


					4MG6O8991R

ACTIVE MOIETY

Amount: