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Details

Stereochemistry ACHIRAL
Molecular Formula C13H14N2
Molecular Weight 198.2637
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TACRINE

SMILES

NC1=C2C=CC=CC2=NC3=C1CCCC3

InChI

InChIKey=YLJREFDVOIBQDA-UHFFFAOYSA-N
InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)

HIDE SMILES / InChI
Molecular Formula C13H14N2
Molecular Weight 198.2637
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 16:45:20 UTC 2023
Edited
by admin
on Sat Dec 16 16:45:20 UTC 2023
Record UNII
4VX7YNB537
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TACRINE
INN   MI   VANDF   WHO-DD  
INN  
Official Name English
TACRINAL
Brand Name English
Tacrine [WHO-DD]
Common Name English
TACRINE [VANDF]
Common Name English
tacrine [INN]
Common Name English
TACRINE [MI]
Common Name English
9-AMINO-1,2,3,4-TETRAHYDROACRIDINE
Systematic Name English
Classification Tree Code System Code
WHO-ATC N06DA01
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
NDF-RT N0000175723
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
WHO-VATC QN06DA01
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
NDF-RT N0000000177
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
NCI_THESAURUS C47792
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
LIVERTOX NBK547868
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
Code System Code Type Description
EPA CompTox
DTXSID1037272
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
CHEBI
45980
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
ChEMBL
CHEMBL95
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
PUBCHEM
1935
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
NCI_THESAURUS
C61961
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
MERCK INDEX
m10424
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY Merck Index
IUPHAR
6687
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
RXCUI
10318
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY RxNorm
SMS_ID
100000082994
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
ECHA (EC/EINECS)
206-291-2
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
EVMPD
SUB10796MIG
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
FDA UNII
4VX7YNB537
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
DRUG CENTRAL
2551
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
INN
800
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
CAS
321-64-2
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
MESH
D013619
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
WIKIPEDIA
TACRINE
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
DRUG BANK
DB00382
Created by admin on Sat Dec 16 16:45:22 UTC 2023 , Edited by admin on Sat Dec 16 16:45:22 UTC 2023
PRIMARY
Related Record Type Details
CYTOCHROME P450 1A1
METABOLIC ENZYME -> SUBSTRATE
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
Histamine N-methyltransferase
OFF-TARGET->INHIBITOR
HNMT inhibitors may increase histamine levels in peripheral tissues and exacerbate histamine-related diseases, such as allergic rhinitis, urticaria, and peptic ulcer disease. However, the effect of HNMT inhibitors on brain function is not yet fully understood. Some studies suggest that an increase in brain histamine levels by novel HNMT inhibitors could contribute to the improvement of brain disorders.
IC50
ACETYLCHOLINESTERASE HUMAN
TARGET -> INHIBITOR
IC50
ACETYLCHOLINESTERASE HUMAN
TARGET -> INHIBITOR
IC50
ALDEHYDE OXIDASE
METABOLIC ENZYME -> INHIBITOR
IC50
Structure of TACRINE HYDROCHLORIDE MONOHYDRATE
SALT/SOLVATE -> PARENT
Structure of TACRINE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
CYTOCHROME P450 1A2
METABOLIC ENZYME -> SUBSTRATE
MAJOR
Related Record Type Details
Structure of 3-HYDROXYTACRINE
METABOLITE -> PARENT
URINE
Structure of VELNACRINE
METABOLITE ACTIVE -> PARENT
URINE
Structure of 4-HYDROXYTACRINE
METABOLITE -> PARENT
URINE
Structure of 9-AMINO-1,2,3,4-TETRAHYDRO-1,3-ACRIDINEDIOL
METABOLITE -> PARENT
URINE
Structure of 2-HYDROXYTACRINE
METABOLITE -> PARENT
URINE
Related Record Type Details
Structure of TACRINE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Tmax PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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