RIZATRIPTAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H19N5
Molecular Weight	269.3449
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of RIZATRIPTAN

Structure Search

SMILES

CN(C)CCC1=CNC2=CC=C(CN3C=NC=N3)C=C12

InChI

InChIKey=ULFRLSNUDGIQQP-UHFFFAOYSA-N

InChI=1S/C15H19N5/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C15H19N5
Molecular Weight	269.3449
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:53:26 UTC 2023` Edited by `admin` on `Fri Dec 15 15:53:26 UTC 2023`
Record UNII	51086HBW8G
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

RIZATRIPTAN

Official Name

English

RIZATRIPTAN [MI]

Common Name

English

MK-462 FREE BASE

Code

English

Rizatriptan [WHO-DD]

Common Name

English

rizatriptan [INN]

Common Name

English

L-705126

Code

English

RIZATRIPTAN [VANDF]

Common Name

English

1H-INDOLE-3-ETHANAMINE, N,N-DIMETHYL-5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-

Systematic Name

English

Classification Tree Code System Code

NDF-RT

N0000175765

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

NCI_THESAURUS

C47794

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

NDF-RT

N0000175764

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

WHO-ATC

N02CC04

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

NDF-RT

N0000175763

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

WHO-VATC

QN02CC04

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

LIVERTOX

857

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

Code System Code Type Description

SMS_ID

100000080246

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

NCI_THESAURUS

C61930

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

MERCK INDEX

m9640

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

Merck Index

FDA UNII

51086HBW8G

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

DRUG CENTRAL

2393

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

DAILYMED

51086HBW8G

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

EVMPD

SUB10346MIG

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

LACTMED

Rizatriptan

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

MESH

C093622

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

WIKIPEDIA

Rizatriptan

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

ChEMBL

CHEMBL905

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

PUBCHEM

5078

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

DRUG BANK

DB00953

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

EPA CompTox

DTXSID2023565

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

CHEBI

48273

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

RXCUI

88014

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

RxNorm

IUPHAR

51

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

CAS

144034-80-0

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

INN

7474

Created by admin on Fri Dec 15 15:53:26 UTC 2023 , Edited by admin on Fri Dec 15 15:53:26 UTC 2023

PRIMARY

Related Record Type Details


					51086HBW8G

EXCRETED UNCHANGED

Comments:

Approximately 26 and 14% of i.v. and oral rizatriptan doses, respectively, were excreted in urine as intact parent drug

Qualification:

URINE


					13RRH2218G

RIZATRIPTAN SULFATE

SALT/SOLVATE -> PARENT


					ZI18M2JAY5

5-HYDROXYTRYPTAMINE RECEPTOR 1D

TARGET -> AGONIST

Amount:


					WR978S7QHH

RIZATRIPTAN BENZOATE

SALT/SOLVATE -> PARENT


					UE9PX4FTL0

5-HYDROXYTRYPTAMINE RECEPTOR 1B

TARGET -> AGONIST


					13RRH2218G

RIZATRIPTAN SULFATE

SOLVATE->ANHYDROUS

Related Record Type Details


					2GYM5ZWF3K

1H-INDOL-6-OL, 3-(2-(DIMETHYLAMINO)ETHYL)-5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-, 6-(HYDROGEN SULFATE)

METABOLITE -> PARENT

Qualification:

URINE


					N8W8CXB9JB

1H-INDOLE-3-ACETIC ACID, 5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-

METABOLITE -> PARENT

Comments:

after oral (10-mg)

Qualification:

URINE

Amount:


					HY8JW8WMA2

6-HYDROXYRIZATRIPTAN

METABOLITE -> PARENT

Qualification:

URINE


					OMH84Z34GP

DESMETHYL RIZATRIPTAN

METABOLITE -> PARENT

Comments:

The mono N-desmethyl metabolite has intrinsic potency that is about 3-fold lower. Its contribution to in vivo efficacy is probably very low or negligible, since circulating concentrations are about one-tenth those of the parent drug


					YNT22B2U4T

RIZATRIPTAN N-OXIDE

METABOLITE -> PARENT

Comments:

after i.v. (3-mg)

Qualification:

URINE

Amount:

Related Record Type Details


					UZK2YWM689

RIZATRIPTAN N,N,N-TRIMETHYLETHANAMMONIUM

IMPURITY -> PARENT

Amount:


					335U9MFY9M

1-((4-HYDRAZINYLPHENYL)METHYL)-1H-1,2,4-TRIAZOLE

IMPURITY -> PARENT

Amount:


					C8C2FFG5AN

N10-DIDESMETHYL RIZATRIPTAN

IMPURITY -> PARENT

Amount:

Related Record Type Details


					51086HBW8G

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				ORAL ADMINISTRATION