CABAZITAXEL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C45H57NO14
Molecular Weight	835.9324
Optical Activity	UNSPECIFIED
Defined Stereocenters	11 / 11
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CABAZITAXEL

Structure Search

SMILES

[H][C@@]12C[C@H](OC)[C@@]3(C)C(=O)[C@H](OC)C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C5=CC=CC=C5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C6=CC=CC=C6

InChI

InChIKey=BMQGVNUXMIRLCK-OAGWZNDDSA-N

InChI=1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C45H57NO14
Molecular Weight	835.9324
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	10 / 11
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:47:11 UTC 2023` Edited by `admin` on `Fri Dec 15 16:47:11 UTC 2023`
Record UNII	51F690397J
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CABAZITAXEL

Official Name

English

TXD258

Code

English

CABAZITAXEL [MI]

Common Name

English

Cabazitaxel [WHO-DD]

Common Name

English

NSC-761432

Code

English

CABAZITAXEL ACETONATE [JAN]

Common Name

English

XRP6258

Code

English

CABAZITAXEL [EMA EPAR]

Common Name

English

CABAZITAXEL [USAN]

Common Name

English

CABAZITAXEL [VANDF]

Common Name

English

CABAZITAXEL [MART.]

Common Name

English

CABAZITAXEL [ORANGE BOOK]

Common Name

English

1-HYDROXY-7.BETA.,10.BETA.-DIMETHOXY-9-OXO-5.BETA.,20-EPOXYTAX-11-ENE-2.ALPHA.,4,13.ALPHA.-TRIYL 4-ACETATE 2-BENZOATE 13-((2R,3S)-3-(((TERT-BUTOXY)CARBONYL)AMINO)-2-HYDROXY-3-PHENYLPROPANOATE)

Common Name

English

XRP-6258

Code

English

TXD-258

Code

English

cabazitaxel [INN]

Common Name

English

JEVTANA

Brand Name

English

Classification Tree Code System Code

NDF-RT

N0000175085

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

NDF-RT

N0000175592

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

NCI_THESAURUS

C67437

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

WHO-ATC

L01CD04

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

EMA ASSESSMENT REPORTS

JETVANA (AUTHORIZED: PROSTATIC, NEOPLASMS)

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

NCI_THESAURUS

C1490

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

LIVERTOX

NBK548533

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

WHO-VATC

QL01CD04

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

Code System Code Type Description

MESH

C552428

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

USAN

XX-92

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

DRUG BANK

DB06772

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

SMS_ID

100000115694

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

CAS

183133-96-2

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

DRUG CENTRAL

4153

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

PUBCHEM

9854073

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

EPA CompTox

DTXSID40171389

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

RXCUI

996051

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

RxNorm

WIKIPEDIA

CABAZITAXEL

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

MERCK INDEX

m2874

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

Merck Index

ChEMBL

CHEMBL1201748

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

NSC

761432

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

DAILYMED

51F690397J

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

NCI_THESAURUS

C66937

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

IUPHAR

6798

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

EVMPD

SUB31282

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

CHEBI

63584

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

FDA UNII

51F690397J

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

INN

8967

Created by admin on Fri Dec 15 16:47:11 UTC 2023 , Edited by admin on Fri Dec 15 16:47:11 UTC 2023

PRIMARY

Related Record Type Details


					51F690397J

EXCRETED UNCHANGED

Qualification:

URINE

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Comments:

As cabazitaxel is mainly metabolized by CYP3A in vitro, strong CYP3A inducers or inhibitors are expected to affect the pharmacokinetics of cabazitaxel.

Interaction Type:

MAJOR

Amount:


					2HQG2N4L58

CABAZITAXEL ETHYL ACETATE SOLVATE

SOLVATE->ANHYDROUS

Amount:


					P8B6SWJ0O9

CABAZITAXEL MONOHYDRATE

SALT/SOLVATE -> PARENT

Amount:


					L0423Z5LDW

CYTOCHROME P450 2C8

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

MINOR

Amount:


					9JX5MZ1I64

CABAZITAXEL ACETONE

SALT/SOLVATE -> PARENT

Amount:


					805SU96HKF

CYTOCHROME P450 3A5

METABOLIC ENZYME -> SUBSTRATE

Comments:

As cabazitaxel is mainly metabolized by CYP3A in vitro, strong CYP3A inducers or inhibitors are expected to affect the pharmacokinetics of cabazitaxel.

Interaction Type:

MAJOR

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					P8B6SWJ0O9

CABAZITAXEL MONOHYDRATE

SOLVATE->ANHYDROUS

Amount:


					51F690397J

EXCRETED UNCHANGED

Qualification:

FECAL

Amount:

Related Record Type Details


					FU44O0K8DA

10-METHYL DOCETAXEL

METABOLITE ACTIVE -> PARENT

Comments:

by the CYP3A4/5 isoenzyme

Amount:


					FX7R2617C2

7-METHYL DOCETAXEL

METABOLITE ACTIVE -> PARENT

Comments:

by the CYP3A4/5 isoenzyme

Amount:


					S9CQ7CB2DC

CABAZITAXEL METABOLITE M07

METABOLITE -> PARENT

Amount:


					699121PHCA

DOCETAXEL ANHYDROUS

METABOLITE ACTIVE -> PARENT

Amount:

Related Record Type Details


					51F690397J

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				intravenous infusion

blood-to-plasma ratio	PHARMACOKINETIC