PREGABALIN

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C8H17NO2
Molecular Weight	159.2261
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PREGABALIN

Structure Search

SMILES

CC(C)C[C@H](CN)CC(O)=O

InChI

InChIKey=AYXYPKUFHZROOJ-ZETCQYMHSA-N

InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C8H17NO2
Molecular Weight	159.2261
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:45:33 UTC 2023` Edited by `admin` on `Fri Dec 15 15:45:33 UTC 2023`
Record UNII	55JG375S6M
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PREGABALIN

Official Name

English

NSC-759256

Code

English

PREGABALIN [ORANGE BOOK]

Common Name

English

(S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID

Systematic Name

English

PREGABALIN [USAN]

Common Name

English

PREGABALIN [VANDF]

Common Name

English

PREGABALIN [JAN]

Common Name

English

PREGABALIN SANDOZ

Brand Name

English

LYRICA CR

Brand Name

English

PREGABALIN [MART.]

Common Name

English

VRONOGABIC

Common Name

English

PREGABALIN MYLAN

Brand Name

English

pregabalin [INN]

Common Name

English

CI-1008

Code

English

Pregabalin [WHO-DD]

Common Name

English

PREGABALIN [HSDB]

Common Name

English

PREGABALIN ZENTIVA

Brand Name

English

LYRICA

Brand Name

English

PREGABALIN [MI]

Common Name

English

PREGABALIN MYLAN PHARMA

Brand Name

English

PD-144723

Code

English

PREGABALIN [USP-RS]

Common Name

English

PREGABALIN SANDOZ GMBH

Brand Name

English

PREGABALIN [USP MONOGRAPH]

Common Name

English

YNP-1807

Code

English

PREGABALIN [EP MONOGRAPH]

Common Name

English

PREGABALIN [EMA EPAR]

Common Name

English

Classification Tree Code System Code

EMA ASSESSMENT REPORTS

PREGABALIN PFIZER (AUTHORIZED: NEURALGIA)

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

EMA ASSESSMENT REPORTS

PREGABALIN ZENTIVA (AUTHORIZED: EPILEPSY)

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

WHO-ATC

N03AX16

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

WHO-VATC

QN03AX16

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

EMA ASSESSMENT REPORTS

PREGABALIN SANDOZ GMBH (AUTHORIZED: EPILEPSY)

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

NCI_THESAURUS

C264

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

LIVERTOX

NBK548053

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

EMA ASSESSMENT REPORTS

PREGABALIN MYLAN PHARMA (AUTHORIZED: EPILEPSY)

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

EMA ASSESSMENT REPORTS

LYRICA (AUTHORIZED: ANXIETY DISORDERS)

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

EMA ASSESSMENT REPORTS

LYRICA (AUTHORIZED: NEURALGIA)

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

EMA ASSESSMENT REPORTS

PREGABALIN MYLAN (AUTHORIZED: EPILEPSY)

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

NCI_THESAURUS

C2198

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

DEA NO.

2782

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

EMA ASSESSMENT REPORTS

PREGABALIN SANDOZ (AUTHORIZED: EPILEPSY)

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

EMA ASSESSMENT REPORTS

LYRICA (AUTHORIZED: EPILEPSY)

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

Code System Code Type Description

DRUG CENTRAL

2255

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

FDA UNII

55JG375S6M

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

NCI_THESAURUS

C64625

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

LACTMED

Pregabalin

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

EVMPD

SUB10023MIG

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

IUPHAR

5484

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

CAS

148553-50-8

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

NSC

759256

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

MESH

C080245

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

HSDB

7530

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

RS_ITEM_NUM

1559618

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

DRUG BANK

DB00230

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

ChEMBL

CHEMBL1059

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

EPA CompTox

DTXSID1045950

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

DAILYMED

55JG375S6M

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

RXCUI

187832

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

RxNorm

PUBCHEM

5486971

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

USAN

HH-23

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

MERCK INDEX

m9113

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

Merck Index

SMS_ID

100000091845

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

INN

7643

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

CHEBI

64356

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

WIKIPEDIA

PREGABALIN

Created by admin on Fri Dec 15 15:45:33 UTC 2023 , Edited by admin on Fri Dec 15 15:45:33 UTC 2023

PRIMARY

Related Record Type Details


					3DA4H8E58A

PREGABALIN SODIUM

SALT/SOLVATE -> PARENT

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					55JG375S6M

EXCRETED UNCHANGED

Qualification:

URINE

Amount:


					Z2CHJ67SHZ

VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1

TARGET -> INHIBITOR

Comments:

ReduceS depolarization-induced calcium influx at nerve terminals, with a consequential reduction in the release of several excitatory neurotransmitters, including glutamate, noradrenaline, substance P, and CGRP.

Qualification:

IC50

Amount:


					NH496X0UJX

INNOVATOR->PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					F7FR5G4KJK

Voltage-dependent calcium channel subunit alpha-2/delta-2

TARGET->LIGAND

Amount:


					8348PZ4JYW

PREGABALIN HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					2HE3CMQ2LB

PREGABALIN METHYL ESTER

PRODRUG -> METABOLITE ACTIVE

Amount:

Related Record Type Details


					81R7ZI0HBG

PREGABALIN, (R)-

IMPURITY -> PARENT

Interaction Type:

ENANTIOMERIC PURITY/HPLC

Qualification:

USP

Amount:


					HJE0MYU5XU

PREGABALIN LACTAM, (±)-

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					FK6BE2M39U

.ALPHA.-D-TAGATOPYRANOSE, 1-DEOXY-1-((4S)-4-(2-METHYLPROPYL)-2-OXO-1-PYRROLIDINYL)-

IMPURITY -> PARENT

Amount:


					6AH4U4DEG6

2,4-DICYANO-3-ISOBUTYLPENTANEDIAMIDE

IMPURITY -> PARENT

Amount:


					EMH1IVR5QH

ISOBUTYLGLUTARIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					GGG8RK3CIS

4,5-DEHYDRO PREGABALIN, (R)-

IMPURITY -> PARENT

Amount:


					9ZG2A5U357

(Z)-2-cyano-5-methylhex-2-enamide

IMPURITY -> PARENT

Amount:


					77M6VOR9AZ

ISOBUTYL GLUTARMONOAMIDE

IMPURITY -> PARENT

Qualification:

USP

Amount:


					42VK59D3YD

3-ISOBUTYLPYRROLIDINE-2,5-DIONE

IMPURITY -> PARENT

Amount:

Related Record Type Details


					55JG375S6M

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC				Elimination PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC