U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C21H26N2O7
Molecular Weight 418.4403
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NIMODIPINE

SMILES

COCCOC(=O)C1=C(C)NC(C)=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OC(C)C

InChI

InChIKey=UIAGMCDKSXEBJQ-UHFFFAOYSA-N
InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3

HIDE SMILES / InChI
Molecular Formula C21H26N2O7
Molecular Weight 418.4403
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:02:29 UTC 2023
Edited
by admin
on Fri Dec 15 18:02:29 UTC 2023
Record UNII
57WA9QZ5WH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NIMODIPINE
EP   INN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
USAN   INN  
Official Name English
NIMODIPINE [VANDF]
Common Name English
NIMODIPINE [MI]
Common Name English
NIMODIPINE [EP MONOGRAPH]
Common Name English
ISOPROPYL 2-METHOXYETHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(M-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE
Systematic Name English
PERIPLUM
Brand Name English
NIMODIPINE [MART.]
Common Name English
NSC-758476
Code English
NIMOTOP
Common Name English
3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-, 3-(2-METHOXYETHYL) 5-(1-METHYLETHYL) ESTER
Systematic Name English
NIMODIPINE [USP IMPURITY]
Common Name English
NIMODIPINE AP
Brand Name English
ADMON
Brand Name English
NIMODIPINE [ORANGE BOOK]
Common Name English
nimodipine [INN]
Common Name English
NIMODIPINE [JAN]
Common Name English
NEMOTAN
Brand Name English
Nimodipine [WHO-DD]
Common Name English
BAY-E-9736
Code English
NIMODIPINE [USP-RS]
Common Name English
BAY E 9736
Code English
NYMALIZE
Brand Name English
NIMODIPINE [USP MONOGRAPH]
Common Name English
NIMODIPINE [USAN]
Common Name English
(±)-NIMODIPINE
Common Name English
Classification Tree Code System Code
EU-Orphan Drug EU/3/15/1554
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
LIVERTOX NBK548041
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
NDF-RT N0000175421
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
NCI_THESAURUS C333
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
NDF-RT N0000000069
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
WHO-ATC C08CA06
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
FDA ORPHAN DRUG 343711
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
NDF-RT N0000007556
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
FDA ORPHAN DRUG 566016
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
FDA ORPHAN DRUG 338611
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
WHO-VATC QC08CA06
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
Code System Code Type Description
DRUG BANK
DB00393
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
DAILYMED
57WA9QZ5WH
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
CAS
66085-59-4
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
MERCK INDEX
m7906
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY Merck Index
PUBCHEM
4497
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
RS_ITEM_NUM
1463858
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
ChEMBL
CHEMBL1428
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
ECHA (EC/EINECS)
266-127-0
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
SMS_ID
100000092273
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
LACTMED
Nimodipine
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
CHEBI
7575
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
IUPHAR
2523
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
EPA CompTox
DTXSID5023370
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
RXCUI
7426
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY RxNorm
FDA UNII
57WA9QZ5WH
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
INN
4528
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
EVMPD
SUB09297MIG
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
NSC
758476
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
WIKIPEDIA
NIMODIPINE
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
DRUG CENTRAL
1937
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
NCI_THESAURUS
C692
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
MESH
D009553
Created by admin on Fri Dec 15 18:02:29 UTC 2023 , Edited by admin on Fri Dec 15 18:02:29 UTC 2023
PRIMARY
Related Record Type Details
Structure of NIMODIPINE, (S)-
ENANTIOMER -> RACEMATE
VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
TARGET -> INHIBITOR
Structure of NIMODIPINE, (R)-
ENANTIOMER -> RACEMATE
Related Record Type Details
Structure of 3-(2-HYDROXYETHYL) 5-ISOPROPYL 2,6-DIMETHYL-4-(3-NITROPHENYL)PYRIDINE-3,5-DICARBOXYLATE
METABOLITE -> PARENT
IN-VIVO
Structure of 3-(2-HYDROXYETHYL) 5-ISOPROPYL 2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE
PARENT -> METABOLITE
IN-VIVO
Structure of 2-HYDROXYETHYL 2-METHYL-4-(3-NITROPHENYL)-5-OXO-5,7-DIHYDROFURO(3,4-B)PYRIDINE-3-CARBOXYLATE
METABOLITE -> PARENT
IN-VITRO
Structure of DEHYDRO NIMODIPINE
METABOLITE -> PARENT
PLASMA
Structure of 3-ISOPROPYL 5-(2-METHOXYETHYL) 2-(HYDROXYMETHYL)-6-METHYL-4-(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE
METABOLITE -> PARENT
IN-VITRO
Related Record Type Details
Structure of DEHYDRO NIMODIPINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of BIS(2-METHOXYETHYL) 2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of BIS(1-METHYLETHYL) 2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of NIMODIPINE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Excretion PHARMACOKINETIC Urination
PHYSICAL
Biological Half-life PHARMACOKINETIC Elimination
PHARMACOKINETIC
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966