CIPROFLOXACIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H18FN3O3
Molecular Weight	331.3415
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CIPROFLOXACIN

Structure Search

SMILES

OC(=O)C1=CN(C2CC2)C3=CC(N4CCNCC4)=C(F)C=C3C1=O

InChI

InChIKey=MYSWGUAQZAJSOK-UHFFFAOYSA-N

InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)

HIDE SMILES / InChI

Molecular Formula	C17H18FN3O3
Molecular Weight	331.3415
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:12:49 UTC 2023` Edited by `admin` on `Sat Dec 16 05:12:49 UTC 2023`
Record UNII	5E8K9I0O4U
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CIPROFLOXACIN

Official Name

English

CIPROFLOXACIN [MART.]

Common Name

English

CIPROFLOXACIN [MI]

Common Name

English

BAY-Q-3939

Code

English

CIPROFLOXACIN [WHO-IP]

Common Name

English

CIPROFLOXACINUM [WHO-IP LATIN]

Common Name

English

CIPROFLOXACIN [USAN]

Common Name

English

3-QUINOLINECARBOXYLIC ACID, 1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-(1-PIPERAZINYL)-

Systematic Name

English

BAY Q 3939

Code

English

CIPROFLOXACIN [JAN]

Common Name

English

ciprofloxacin [INN]

Common Name

English

CIPRODEX COMPONENT CIPROFLOXACIN

Common Name

English

CIPROFLOXACIN [USP MONOGRAPH]

Common Name

English

CIPROFLOXACIN [USP-RS]

Common Name

English

BAY O 9867 FREE BASE

Code

English

1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-(1-PIPERAZINYL)-3-QUINOLINE-CARBOXYLIC ACID

Systematic Name

English

CIPROFLOXACIN [EP MONOGRAPH]

Common Name

English

CIPROFLOXACIN [VANDF]

Common Name

English

BAY-O-9867 FREE BASE

Code

English

CIPROFLOXACIN COMPONENT OF CIPRODEX

Common Name

English

ENROFLOXACIN FOR VETERINARY USE IMPURITY B [EP IMPURITY]

Common Name

English

CIPROFLOXACIN [HSDB]

Common Name

English

OTIPRIO

Brand Name

English

NSC-758467

Code

English

BAYQ3939

Code

English

CIPROFLOXACIN [ORANGE BOOK]

Common Name

English

Ciprofloxacin [WHO-DD]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

422314

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

WHO-VATC

QJ01MA02

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

NDF-RT

N0000175937

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

NDF-RT

N0000007606

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

FDA ORPHAN DRUG

216905

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

WHO-ATC

S01AE03

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

EU-Orphan Drug

EU/3/07/469

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

WHO-ATC

S02AA15

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

WHO-ATC

S03AA07

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

FDA ORPHAN DRUG

297209

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

WHO-VATC

QS01AE03

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

FDA ORPHAN DRUG

718519

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

NCI_THESAURUS

C280

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

FDA ORPHAN DRUG

230806

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

FDA ORPHAN DRUG

339911

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

6.2.2

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

NCI_THESAURUS

C795

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

WHO-ATC

S01AX13

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

WHO-ATC

J01MA02

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

WHO-ATC

J01RA12

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

WHO-ATC

J01RA10

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

WHO-VATC

QS03AA07

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

WHO-VATC

QS02AA15

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

LIVERTOX

NBK548066

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

WHO-ATC

J01RA11

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

28

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

FDA ORPHAN DRUG

369812

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

Code System Code Type Description

MESH

D002939

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

DRUG BANK

DB00537

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

WIKIPEDIA

CIPROFLOXACIN

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

ChEMBL

CHEMBL8

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

RXCUI

2551

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

RxNorm

WHO INTERNATIONAL PHARMACOPEIA

CIPROFLOXACIN

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

Description: A white to pale yellow, crystalline powder.Solubility: Practically insoluble in water; very slightly soluble in ethanol (~750 g/l) TS and dichloromethane R.Category: Antibacterial.Storage: Ciprofloxacin should be kept in a well-closed container, protected from light.Additional information: Ciprofloxacin exists in different polymorphic forms.

FDA UNII

5E8K9I0O4U

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

SMS_ID

100000092110

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

CAS

85721-33-1

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

CHEBI

100241

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

NCI_THESAURUS

C375

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

MERCK INDEX

m3583

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

Merck Index

USAN

Y-54

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

DRUG CENTRAL

659

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

PUBCHEM

2764

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

EPA CompTox

DTXSID8022824

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

HSDB

6987

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

EVMPD

SUB07470MIG

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

DAILYMED

5E8K9I0O4U

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

NSC

758467

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

INN

5446

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

RS_ITEM_NUM

1134313

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

LACTMED

Ciprofloxacin

Created by admin on Sat Dec 16 05:12:50 UTC 2023 , Edited by admin on Sat Dec 16 05:12:50 UTC 2023

PRIMARY

Related Record Type Details


					4BA73M5E37

CIPROFLOXACIN HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					0MP32MFP6C

CIPROFLOXACIN HYDROCHLORIDE ANHYDROUS

SALT/SOLVATE -> PARENT


					VK4SQL11C0

CYTOCHROME P450 1A2

METABOLIC ENZYME -> INHIBITOR

Interaction Type:

POTENT


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					RA8G5XH9FW

BACTERIAL DNA GYRASE

TARGET -> INHIBITOR

Amount:


					YK3OT8B1UG

CIPROFLOXACIN HEMIHEPTAHYDRATE

SOLVATE->ANHYDROUS


					6NP3XSMIP3

MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1

TRANSPORTER -> INHIBITOR

Qualification:

IC50

Amount:


					B46KUN2O9L

MATE-2

TRANSPORTER -> INHIBITOR

Qualification:

IC50

Amount:


					G43NV09DD4

CIPROFLOXACIN HYDROCHLORIDE SESQUIHYDRATE

SALT/SOLVATE -> PARENT


					YK3OT8B1UG

CIPROFLOXACIN HEMIHEPTAHYDRATE

SALT/SOLVATE -> PARENT

Amount:


					EQ65GND522

Ciprofloxacin hydrogen sulfate

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					7H561ZF07L

SULFOCIPROFLOXACIN

METABOLITE LESS ACTIVE -> PARENT


					Y901RQ8CDM

OXOCIPROFLOXACIN

METABOLITE LESS ACTIVE -> PARENT

Amount:


					Y7A089AJ9Y

DESETHYLENECIPROFLOXACIN

METABOLITE LESS ACTIVE -> PARENT

Amount:

Related Record Type Details


					FGL76AE74S

DECARBOXYCIPROFLOXACIN

IMPURITY -> PARENT


					Y7A089AJ9Y

DESETHYLENECIPROFLOXACIN

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					X0FPD89RI4

DESFLUOROCIPROFLOXACIN

IMPURITY -> PARENT


					3DX3XEK1BN

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					UPG5846EWW

7-CHLORO-1-CYCLOPROPYL-4-OXO-6-(PIPERAZIN-1-YL)-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID

IMPURITY -> PARENT


					UPG5846EWW

7-CHLORO-1-CYCLOPROPYL-4-OXO-6-(PIPERAZIN-1-YL)-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID

IMPURITY -> PARENT


					95HKY59ZG6

FLUOROQUINOLONIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					SXU2HM2W4Q

6-CHLORO-6-DEFLUORO CIPROFLOXACIN

IMPURITY -> PARENT


					MM5YD792QW

HYDROXYCIPROFLOXACIN

IMPURITY -> PARENT

Related Record Type Details


					5E8K9I0O4U

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ORAL BIOAVAILABILITY	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				ORAL, EXTENDED-RELEASE PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC

PROTEIN BINDING (SERUM PROTEINS)	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC				NEONATES PHARMACOKINETIC CHILDREN 91 TO 5 YEARS) PHARMACOKINETIC EXTENDED-RELEASE TABLET PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC

Route of Elimination	PHARMACOKINETIC				FECAL PHARMACOKINETIC BILE PHARMACOKINETIC RENAL CLEARANCE PHARMACOKINETIC BILE: SMALL AMOUNT RECOVERED IN THE BILE AS UNCHANGED DRUG PHARMACOKINETIC RENAL, EXTENDED-RELEASE TABLET PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC