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Details

Stereochemistry ACHIRAL
Molecular Formula C8H15N7O2S3
Molecular Weight 337.445
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FAMOTIDINE

SMILES

NC(=N)NC1=NC(CSCCC(=N)NS(N)(=O)=O)=CS1

InChI

InChIKey=XUFQPHANEAPEMJ-UHFFFAOYSA-N
InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

HIDE SMILES / InChI
Molecular Formula C8H15N7O2S3
Molecular Weight 337.445
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:52:37 UTC 2023
Edited
by admin
on Fri Dec 15 15:52:37 UTC 2023
Record UNII
5QZO15J2Z8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FAMOTIDINE
EP   HSDB   INN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
FLUXID
Brand Name English
FAMOTIDINE COMPONENT OF PEPCID COMPLETE
Common Name English
GASTER
Brand Name English
MUCLOX
Brand Name English
AMFAMOX
Brand Name English
FAMOXAL
Brand Name English
PEPDUL
Brand Name English
Famotidine [WHO-DD]
Common Name English
[1-Amino-3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]propylidene]sulfamide
Systematic Name English
FAMOTIDINE [MART.]
Common Name English
PEPCIDINE
Brand Name English
FAMOTIDINE [JAN]
Common Name English
LECEDIL
Brand Name English
MOTIAX
Brand Name English
L 643341
Code English
GANOR
Brand Name English
FAMOTIDINE [MI]
Common Name English
famotidine [INN]
Common Name English
PEPCID COMPLETE COMPONENT FAMOTIDINE
Common Name English
GASTRIDIN
Brand Name English
FAMODIL
Brand Name English
FAMOTIDINE [VANDF]
Common Name English
FAMOTIDINE [USP MONOGRAPH]
Common Name English
YM-11170
Code English
GASTROPEN
Brand Name English
PROPANIMIDAMIDE, N'-(AMINOSULFONYL)-3-(((2-((DIAMINOMETHYLENE)AMINO)-4-THIAZOLYL)METHYL)THIO)-
Systematic Name English
FAMOTIDINE [USP IMPURITY]
Common Name English
FAMOTIDINE [HSDB]
Common Name English
PEPCIDAC
Brand Name English
PEPDINE
Brand Name English
FADUL
Brand Name English
FAMOTIDINE [USP-RS]
Common Name English
FAMOTIDINE [USAN]
Common Name English
FAMOTIDINE [ORANGE BOOK]
Common Name English
FAMOSAN
Brand Name English
PEPCID
Brand Name English
FAMOTIDINE [EP MONOGRAPH]
Common Name English
NSC-757810
Code English
MK-208
Code English
3-((((2-(DIAMINOMETHYLENE)AMINO)-4-THIAZOLYL)METHYL)THIO)-N-SULFAMOYLPROPIONAMIDINE
Common Name English
Classification Tree Code System Code
WHO-ATC A02BA03
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
NDF-RT N0000175784
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
WHO-VATC QA02BA03
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
NCI_THESAURUS C29702
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
WHO-ATC A02BA53
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
LIVERTOX NBK548228
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
WHO-VATC QA02BA53
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
NDF-RT N0000000151
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
Code System Code Type Description
LACTMED
Famotidine
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
EPA CompTox
DTXSID5023039
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
DRUG BANK
DB00927
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
NSC
757810
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
MESH
D015738
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
EVMPD
SUB07503MIG
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
DAILYMED
5QZO15J2Z8
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
INN
5217
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
SMS_ID
100000092363
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
IUPHAR
7074
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
PUBCHEM
3325
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
MERCK INDEX
m5241
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY Merck Index
ChEMBL
CHEMBL902
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
RXCUI
4278
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY RxNorm
WIKIPEDIA
FAMOTIDINE
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
RS_ITEM_NUM
1269200
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
CHEBI
4975
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
DRUG CENTRAL
1129
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
USAN
W-33
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
HSDB
3572
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
NCI_THESAURUS
C29045
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
FDA UNII
5QZO15J2Z8
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
CAS
76824-35-6
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
Related Record Type Details
MATE-2
TRANSPORTER -> INHIBITOR
MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1
TRANSPORTER -> INHIBITOR
Structure of FAMOTIDINE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
USP
OAT-1
TRANSPORTER -> INHIBITOR
IC50
OCT-1
TRANSPORTER -> INHIBITOR
Structure of FAMOTIDINE
EXCRETED UNCHANGED
Following IV administration
URINE
HISTAMINE H2 RECEPTOR
TARGET->INVERSE AGONIST
The mean minimum daily requirement of famotidine to control gastric acid hypersecretion was 0.24 g (range 0.08–0.48 g) compared with 2.1 g (range 0.6–3.6 g) for ranitidine and 7.8 g (range 1.2–13.2 g) for cimetidine. is nine times more potent than ranitidine and 32 times more potent than cimetidine, has a longer duration of action than ranitidine or cimetidine,
OCT-2
TRANSPORTER -> INHIBITOR
IC50
OCT-3
TRANSPORTER -> INHIBITOR
OCT-1
TRANSPORTER -> SUBSTRATE
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
HISTAMINE H2 RECEPTOR
TARGET->INVERSE AGONIST
OAT-3
TRANSPORTER -> NON-INHIBITOR
IC50
Structure of FAMOTIDINE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
Related Record Type Details
Structure of FAMOTIDINE SULFOXIDE
METABOLITE -> PARENT
URINE
Related Record Type Details
Structure of FAMOTIDINE CYANOAMIDINE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.4
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 3-((2-(DIAMINOMETHYLENEAMINO)THIAZOL-4-YL)METHYLTHIO)PROPANIMIDAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of FAMOTIDINE PROPANAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of FAMOTIDINE PROPIONIC ACID
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of FAMOTIDINE PROPANAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of FAMOTIDINE DIMER
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 2.5
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of FAMOTIDINE SULFAMOYL PROPANAMIDE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.9
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of FAMOTIDINE DIMER
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of FAMOTIDINE DISULFIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of FAMOTIDINE SULFAMOYL PROPANAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of FAMOTIDINE CYANOAMIDINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of FAMOTIDINE PROPIONIC ACID
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.7
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 3-((2-(DIAMINOMETHYLENEAMINO)THIAZOL-4-YL)METHYLTHIO)PROPANIMIDAMIDE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 0.19
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of FAMOTIDINE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
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