MEFLOQUINE HYDROCHLORIDE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H16F6N2O.ClH
Molecular Weight	414.773
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MEFLOQUINE HYDROCHLORIDE

Structure Search

SMILES

Cl.[H][C@@]1(CCCCN1)[C@@H](O)C2=C3C=CC=C(C3=NC(=C2)C(F)(F)F)C(F)(F)F

InChI

InChIKey=WESWYMRNZNDGBX-YLCXCWDSSA-N

InChI=1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C17H16F6N2O
Molecular Weight	378.3122
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:24:53 UTC 2023` Edited by `admin` on `Fri Dec 15 15:24:53 UTC 2023`
Record UNII	5Y9L3636O3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MEFLOQUINE HYDROCHLORIDE

Official Name

English

MEFLOQUINE HYDROCHLORIDE [USP MONOGRAPH]

Common Name

English

MEFLOQUINE HYDROCHLORIDE [MART.]

Common Name

English

RO-215998001

Code

English

MEFLOQUINE HYDROCHLORIDE [WHO-IP]

Common Name

English

MEFLOQUINI HYDROCHLORIDUM [WHO-IP LATIN]

Common Name

English

NSC-157387

Code

English

MEFLOQUINE HCL

Common Name

English

MEFLOQUINE HYDROCHLORIDE [USP-RS]

Common Name

English

4-QUINOLINEMETHANOL, .ALPHA.-2-PIPERIDINYL-2,8-BIS(TRIFLUOROMETHYL)-, MONOHYDROCHLORIDE, (R*,S*)- (±)-

Common Name

English

DL-ERYTHRO-.ALPHA.-2-PIPERIDYL-2,8-BIS(TRIFLUOROMETHYL)-4-QUINOLINEMETHANOL MONOHYDROCHLORIDE

Common Name

English

MEFLOQUINE HYDROCHLORIDE [VANDF]

Common Name

English

RO-21-5998/001

Code

English

MEFLOQUINE HYDROCHLORIDE [EP MONOGRAPH]

Common Name

English

Mefloquine hydrochloride [WHO-DD]

Common Name

English

RO-21-5998

Code

English

WR-142490

Code

English

LORIAM

Brand Name

English

LARIAM

Brand Name

English

MEFLOQUINE HYDROCHLORIDE [ORANGE BOOK]

Common Name

English

MEFLOQUINE HYDROCHLORIDE [EP IMPURITY]

Common Name

English

MEFLOQUINE HYDROCHLORIDE [USAN]

Common Name

English

MEFLOQUINE HYDROCHLORIDE [JAN]

Common Name

English

RO 21-5998/001

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

18687

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

NCI_THESAURUS

C271

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

FDA ORPHAN DRUG

26287

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

Code System Code Type Description

USAN

W-48

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

PRIMARY

DRUG BANK

DBSALT000311

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

PRIMARY

CAS

51773-92-3

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

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EVMPD

SUB14492MIG

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

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PUBCHEM

65329

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

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NSC

157387

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

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EPA CompTox

DTXSID1047819

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

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NCI_THESAURUS

C47600

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

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ChEMBL

CHEMBL416956

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

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SMS_ID

100000076533

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

PRIMARY

DAILYMED

5Y9L3636O3

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

PRIMARY

FDA UNII

5Y9L3636O3

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

PRIMARY

RS_ITEM_NUM

1379059

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

PRIMARY

RXCUI

82130

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

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RxNorm

ECHA (EC/EINECS)

257-412-0

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

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MERCK INDEX

m7142

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

PRIMARY

Merck Index

WHO INTERNATIONAL PHARMACOPEIA

MEFLOQUINE HYDROCHLORIDE

Created by admin on Fri Dec 15 15:24:53 UTC 2023 , Edited by admin on Fri Dec 15 15:24:53 UTC 2023

PRIMARY

Description: A white to slightly yellow, crystalline powder. Solubility: Very slightly soluble in water; freely soluble in methanol R; soluble in ethanol (~750 g/L) TS; sparingly soluble in dichloromethane R. Category: Antimalarial. Storage: Mefloquine hydrochloride should be kept in a tightly closed container, protected from light. Additional information: Mefloquine hydrochloride may exhibit polymorphism. It melts at about 260 ?C, with decomposition. Requirement: Mefloquine hydrochloride contains not less than 99.0% and not more than 101.0% of C17H16F6N2O,HCl, calculated with reference to the anhydrous substance.

Related Record Type Details


					326VC85GV6

MEFLOQUINE HYDROCHLORIDE, (+)

ENANTIOMER -> RACEMATE

Amount:

Related Record Type Details


					GB2GL4S36Z

REL-(.ALPHA.R)-.ALPHA.-(2R)-2-PIPERIDINYL-2,8-BIS(TRIFLUOROMETHYL)-4-QUINOLINEMETHANOL

IMPURITY -> PARENT


					P4QYS7TV8C

THREO-MEFLOQUINE, (-)-

IMPURITY -> PARENT

Comments:

MEFLOQUINE HYDROCHLORIDE Impurity A. In the chromatogram obtained with solution (1) the following impurities, if present, are eluted at the following relative retention with reference to mefloquine (retention time about 3.9 minutes): impurity A about 0.9. In the chromatogram obtained with solution (1):the area of any peak corresponding to impurity A is not greater than the area of the principal peak in the chromatogram obtained with solution (2) (0.2%).

Amount:


					F292WNT81D

(2,8-BIS(TRIFLUOROMETHYL)QUINOLIN-4-YL)(PYRIDIN-2-YL)METHANONE

IMPURITY -> PARENT

Comments:

MEFLOQUINE HYDROCHLORIDE Impurity B. In the chromatogram obtained with solution (1) the following impurity, if present, is eluted at the following relative retention with reference to mefloquine (retention time about 3.9 minutes): impurity B about 7.4.


					LR2SRP2P6J

(2,8-BIS-TRIFLUOROMETHYL-QUINOLIN-4-YL)-PYRIDIN-2-YL-METHANOL

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Related Record Type Details


					TML814419R

ACTIVE MOIETY