ETELCALCETIDE

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NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C38H73N21O10S2
Molecular Weight	1048.251
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ETELCALCETIDE

Structure Search

SMILES

C[C@@H](NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](C)NC(=O)[C@@H](CSSC[C@H](N)C(O)=O)NC(C)=O)C(=O)N[C@H](CCCNC(N)=N)C(N)=O

InChI

InChIKey=ANIAZGVDEUQPRI-ZJQCGQFWSA-N

InChI=1S/C38H73N21O10S2/c1-18(28(62)56-22(27(40)61)8-4-12-49-35(41)42)53-30(64)23(9-5-13-50-36(43)44)58-32(66)25(11-7-15-52-38(47)48)59-31(65)24(10-6-14-51-37(45)46)57-29(63)19(2)54-33(67)26(55-20(3)60)17-71-70-16-21(39)34(68)69/h18-19,21-26H,4-17,39H2,1-3H3,(H2,40,61)(H,53,64)(H,54,67)(H,55,60)(H,56,62)(H,57,63)(H,58,66)(H,59,65)(H,68,69)(H4,41,42,49)(H4,43,44,50)(H4,45,46,51)(H4,47,48,52)/t18-,19-,21+,22-,23-,24-,25-,26-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C38H73N21O10S2
Molecular Weight	1048.251
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 20:19:18 UTC 2023` Edited by `admin` on `Fri Dec 15 20:19:18 UTC 2023`
Record UNII	60ME133FJB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ETELCALCETIDE

Official Name

English

ETELCALCETIDE [MI]

Common Name

English

TELCALCETIDE

Common Name

English

Etelcalcetide [WHO-DD]

Common Name

English

ONO-5163

Code

English

VELCALCETIDE

Common Name

English

N-ACETYL-D-CYSTEINYL-D-ALANYL-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ALANYL-D-ARGININAMIDE DISULFIDE WITH L-CYSTEINE

Common Name

English

etelcalcetide [INN]

Common Name

English

KAI-4169

Code

English

PARSABIV

Brand Name

English

ETELCALCETIDE [USAN]

Common Name

English

D-ARGININAMIDE, N-ACETYL-D-CYSTEINYL-D-ALANYL-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ALANYL-, DISULFIDE WITH L-CYSTEINE

Common Name

English

AMG-416

Code

English

ETELCALCETIDE [ORANGE BOOK]

Common Name

English

Classification Tree Code System Code

WHO-ATC

H05BX04

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

NCI_THESAURUS

C78275

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

FDA ORPHAN DRUG

567616

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

NDF-RT

N0000175902

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

Code System Code Type Description

FDA UNII

60ME133FJB

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

PUBCHEM

71511839

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

DRUG BANK

DB12865

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

WIKIPEDIA

Etelcalcetide

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

EVMPD

SUB178987

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

ChEMBL

CHEMBL3545184

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

EPA CompTox

DTXSID70155132

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

SMS_ID

100000164426

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

DAILYMED

60ME133FJB

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

USAN

ZZ-124

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

NCI_THESAURUS

C129712

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

DRUG CENTRAL

5181

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

MERCK INDEX

m11978

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

CAS

1262780-97-1

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

INN

9809

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

RXCUI

1876119

Created by admin on Fri Dec 15 20:19:18 UTC 2023 , Edited by admin on Fri Dec 15 20:19:18 UTC 2023

PRIMARY

Related Record Type Details


					72PT5993DU

ETELCALCETIDE HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Comments:

Etelcalcetide is primarily bound to plasma albumin and the plasma non-covalent protein binding is less than 50%.

Interaction Type:

BINDING

Amount:


					OY9O3N5W0A

EXTRACELLULAR CALCIUM-SENSING RECEPTOR

TARGET -> AGONIST

Related Record Type Details


					62UB4Z963Y

KP-2067 GLUTATHIONE DISULFIDE

METABOLITE LESS ACTIVE -> PARENT


					C6ZIA257AX

KP-2067

METABOLITE ACTIVE -> PARENT

Related Record Type Details


					60ME133FJB

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC