ALLOPURINOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H4N4O
Molecular Weight	136.1115
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

O=C1N=CNC2=C1C=NN2

InChI

InChIKey=OFCNXPDARWKPPY-UHFFFAOYSA-N

InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)

HIDE SMILES / InChI

Molecular Formula	C5H4N4O
Molecular Weight	136.1115
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical
Record UNII	63CZ7GJN5I
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

ALLOPURINOL

Official Name

English

ALLOPURINOL [MART.]

Common Name

English

1H-PYRAZOLO(3,4-D)PYRIMIDIN-4-OL

Systematic Name

English

ALLOPURINOL [EP IMPURITY]

Common Name

English

ALLOPURINOL [WHO-IP]

Common Name

English

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Classification Tree

Code System

Code

Enzyme Inhibitor

NCI_THESAURUS

C1637

Preparations inhibiting uric acid production

WHO-VATC

QM04AA51

Antineoplastic, immunosuppressives and medicines used in Palliative care

WHO-ESSENTIAL MEDICINES LIST

8.2

Protective Agent

NCI_THESAURUS

C921

Preparations inhibiting uric acid production

WHO-VATC

QM04AA01

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Code System

Code

Type

Description

DRUG CENTRAL

124

PRIMARY

CAS

184856-42-6

SUPERSEDED

DAILYMED

63CZ7GJN5I

PRIMARY

CHEBI

40279

PRIMARY

NSC

1390

PRIMARY

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Related Record

Type

Details


					63CZ7GJN5I

ALLOPURINOL

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

USP

Amount:

RELATIONSHIP_AMOUNT [98 to 102] WEIGHT PERCENT (limits)


					428673RC2Z

ALLOPURINOL SODIUM

SALT/SOLVATE -> PARENT


					5840721PJZ

OAT-2

TRANSPORTER -> SUBSTRATE

Amount:


					63CZ7GJN5I

ALLOPURINOL

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

EP

Amount:

RELATIONSHIP_AMOUNT [97 to 102] WEIGHT PERCENT (limits)


					ATA6VBL43H

XANTHINE DEHYDROGENASE/OXIDASE

TARGET -> INHIBITOR

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Type

Details


					G97OZE5068

OXYPURINOL

METABOLITE ACTIVE -> PARENT

Interaction Type:

MAJOR

Amount:

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Type

Details


					27RFH0GB4R

HYDRAZINE

IMPURITY -> PARENT

Comments:

In USP/NF not more than 10 ppm of hydrazine is found

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

RELATIONSHIP_AMOUNT [<0.0625] PPM (limits)


					9GY5HA1GAA

ETHYL 5-AMINO-1H-PYRAZOLE-4-CARBOXYLATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

RELATIONSHIP_AMOUNT [<0.2] PERCENT PEAK AREA (limits)


					G43E3B7590

1H-PYRAZOLE-4-CARBOXAMIDE, 3-AMINO-

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

RELATIONSHIP_AMOUNT [<0.2] PERCENT PEAK AREA (limits)


					0204JQL303

5-FORMYLAMINO-1H-PYRAZOLE-4-CARBOXAMIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

RELATIONSHIP_AMOUNT [<0.1] PERCENT PEAK AREA (limits)


					08NO0BP96Y

5-(4H-1,2,4-TRIAZOL-4-YL)-1H-PYRAZOLE-4-CARBOXAMIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

RELATIONSHIP_AMOUNT [<0.2] PERCENT PEAK AREA (limits)

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Type

Details


					63CZ7GJN5I

ALLOPURINOL

ACTIVE MOIETY

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Name	Property Type	Amount
Volume of Distribution	PHARMACOKINETIC	1.6 Liters/Kilogram (average)

Biological Half-life	PHARMACOKINETIC	[1 to 2] hours (average)