ENTOSPLETINIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H21N7O
Molecular Weight	411.4591
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ENTOSPLETINIB

Structure Search

SMILES

C1CN(CCO1)C2=CC=C(NC3=NC(=CN4C=CN=C34)C5=CC6=C(C=NN6)C=C5)C=C2

InChI

InChIKey=XSMSNFMDVXXHGJ-UHFFFAOYSA-N

InChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)

HIDE SMILES / InChI

Molecular Formula	C23H21N7O
Molecular Weight	411.4591
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:45:48 UTC 2023` Edited by `admin` on `Sat Dec 16 10:45:48 UTC 2023`
Record UNII	6I3O3W6O3B
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ENTOSPLETINIB

Official Name

English

GS-9973

Code

English

SYK INHIBITOR GS-9973

Code

English

ENTOSPLETINIB [USAN]

Common Name

English

6-(1H-INDAZOL-6-YL)-N-(4-(MORPHOLIN-4-YL)PHENYL)IMIDAZO(1,2-A)PYRAZIN-8-AMINE

Systematic Name

English

Entospletinib [WHO-DD]

Common Name

English

IMIDAZO(1,2-A)PYRAZIN-8-AMINE, 6-(1H-INDAZOL-6-YL)-N-(4-(4-MORPHOLINYL)PHENYL)-

Systematic Name

English

entospletinib [INN]

Common Name

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/17/1922

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

NCI_THESAURUS

C1967

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

FDA ORPHAN DRUG

569616

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

NCI_THESAURUS

C129825

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

FDA ORPHAN DRUG

510115

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

Code System Code Type Description

EVMPD

SUB182049

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

PRIMARY

INN

9874

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

PRIMARY

FDA UNII

6I3O3W6O3B

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

PRIMARY

SMS_ID

100000168561

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

PRIMARY

DRUG BANK

DB12121

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

PRIMARY

EPA CompTox

DTXSID001317670

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

PRIMARY

NCI_THESAURUS

C105402

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

PRIMARY

ChEMBL

CHEMBL3265032

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

PRIMARY

WIKIPEDIA

Entospletinib

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

PRIMARY

CAS

1229208-44-9

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

PRIMARY

USAN

CD-104

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

PRIMARY

PUBCHEM

59473233

Created by admin on Sat Dec 16 10:45:48 UTC 2023 , Edited by admin on Sat Dec 16 10:45:48 UTC 2023

PRIMARY

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					JS20X60RRY

TYROSINE-PROTEIN KINASE SYK

TARGET -> INHIBITOR

Amount:


					5H88K2AQ3R

ENTOSPLETINIB DIMESYLATE HEMIHYDRATE

SALT/SOLVATE -> PARENT

Amount:


					4N0Q3I064C

ENTOSPLETINIB DIMESYLATE

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					6I3O3W6O3B

ACTIVE MOIETY

Amount: