ULIPRISTAL

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C28H35NO3
Molecular Weight	433.5824
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ULIPRISTAL

Structure Search

SMILES

[H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)C[C@]([H])(C3=CC=C(C=C3)N(C)C)C4=C5CCC(=O)C=C5CC[C@@]24[H]

InChI

InChIKey=HKDLNTKNLJPAIY-WKWWZUSTSA-N

InChI=1S/C28H35NO3/c1-17(30)28(32)14-13-25-23-11-7-19-15-21(31)10-12-22(19)26(23)24(16-27(25,28)2)18-5-8-20(9-6-18)29(3)4/h5-6,8-9,15,23-25,32H,7,10-14,16H2,1-4H3/t23-,24+,25-,27-,28-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C28H35NO3
Molecular Weight	433.5824
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:17:44 UTC 2023` Edited by `admin` on `Fri Dec 15 17:17:44 UTC 2023`
Record UNII	6J5J15Q2X8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ULIPRISTAL

Official Name

English

ULIPRISTAL ACETATE ULIPRISTAL [MI]

Common Name

English

ULIPRISTAL [VANDF]

Common Name

English

ULIPRISTAL [USAN]

Common Name

English

Ulipristal [WHO-DD]

Common Name

English

11β-[4-(Dimethylamino)phenyl]-17-hydroxy-19-norpregna-4,9-diene-3,20-dione

Common Name

English

ulipristal [INN]

Common Name

English

ULIPRISTAL [EMA EPAR]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1891

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

WHO-ATC

G03XB02

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

WHO-VATC

QG03XB02

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

WHO-ATC

G03AD02

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

WHO-VATC

QG03AD02

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

NDF-RT

N0000191263

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

Code System Code Type Description

EVMPD

SUB30471

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

PRIMARY

DRUG CENTRAL

4166

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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DAILYMED

6J5J15Q2X8

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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FDA UNII

6J5J15Q2X8

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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DRUG BANK

DB08867

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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CAS

159811-51-5

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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EPA CompTox

DTXSID501025842

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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MERCK INDEX

m11300

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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Merck Index

NCI_THESAURUS

C91056

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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MESH

C094854

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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RXCUI

1005921

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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RxNorm

PUBCHEM

13559281

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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LACTMED

Ulipristal

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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NDF-RT

N0000191262

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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Selective Progesterone Receptor Modulators [MoA]

ChEMBL

CHEMBL2103846

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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SMS_ID

100000093430

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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INN

8367

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

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USAN

WW-157

Created by admin on Fri Dec 15 17:17:44 UTC 2023 , Edited by admin on Fri Dec 15 17:17:44 UTC 2023

PRIMARY

Related Record Type Details


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Amount:


					DXN1OSB4IB

PROGESTERONE RECEPTOR

TARGET -> AGONIST

Comments:

Ulipristal acetate is an orally-active progesterone agonist/antagonist with antagonistic and partial agonistic effects at the progesterone receptor.

Interaction Type:

BINDING


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Comments:

Concomitant administration of CYP3A4 inhibitors may inhibit the metabolism of ulipristal acetate and cause increased plasma concentration of ulipristal acetate. In addition, concomitant administration of CYP3A4 inducers may reduce plasma concentrations of ulipristal acetate and may result in decrease in efficacy.

Interaction Type:

MAJOR


					FZW85LW99M

GLUCOCORTICOID RECEPTOR

TARGET -> INHIBITOR

Related Record Type Details


					6J5J15Q2X8

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				oral administration