GLIMEPIRIDE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H34N4O5S
Molecular Weight	490.616
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of GLIMEPIRIDE

Structure Search

SMILES

CCC1=C(C)CN(C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)N[C@H]3CC[C@H](C)CC3)C1=O

InChI

InChIKey=WIGIZIANZCJQQY-RUCARUNLSA-N

InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19-

HIDE SMILES / InChI

Molecular Formula	C24H34N4O5S
Molecular Weight	490.616
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:51:28 UTC 2023` Edited by `admin` on `Fri Dec 15 15:51:28 UTC 2023`
Record UNII	6KY687524K
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

GLIMEPIRIDE

Official Name

English

Glimepiride [WHO-DD]

Common Name

English

GLIMEPIRIDE [ORANGE BOOK]

Common Name

English

AMARYL

Brand Name

English

GLIMEPIRIDE [USP-RS]

Common Name

English

GLIMEPIRIDE [MI]

Common Name

English

GLIMEPIRIDE [EP MONOGRAPH]

Common Name

English

GLIMEPIRIDE [USP IMPURITY]

Common Name

English

HOE 490

Code

English

NSC-759809

Code

English

DUETACT COMPONENT GLIMEPIRIDE

Common Name

English

GLIMEPIRIDE [USP MONOGRAPH]

Common Name

English

GLIMEPIRIDE [MART.]

Common Name

English

glimepiride [INN]

Common Name

English

GLIMEPIRIDE [VANDF]

Common Name

English

1H-PYRROLE-1-CARBOXAMIDE, 3-ETHYL-2,5-DIHYDRO-4-METHYL-N-(2-(4-(((((4-METHYLCYCLOHEXYL)AMINO)CARBONYL)AMINO)SULFONYL)PHENYL)ETHYL)-2-OXO-, TRANS-

Common Name

English

GLIMEPIRIDE [USAN]

Common Name

English

GLIMEPIRIDE [JAN]

Common Name

English

GLIMEPIRIDE COMPONENT OF DUETACT

Common Name

English

GLIMEPIRIDE [EMA EPAR]

Common Name

English

1-((P-(2-(3-ETHYL-4-METHYL-2-OXO-3-PYRROLINE-1-CARBOXAMIDO)ETHYL)PHENYL)SULFONYL)-3-(TRANS-4-METHYLCYCLOHEXYL)UREA

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000008054

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

LIVERTOX

459

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

NDF-RT

N0000008054

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

WHO-VATC

QA10BD06

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

NDF-RT

N0000008054

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

WHO-VATC

QA10BB12

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

NCI_THESAURUS

C97936

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

WHO-ATC

A10BB12

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

WHO-ATC

A10BD06

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

WHO-ATC

A10BD04

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

NDF-RT

N0000175608

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

WHO-VATC

QA10BD04

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

Code System Code Type Description

ChEMBL

CHEMBL1481

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

NCI_THESAURUS

C29073

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

RXCUI

25789

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

RxNorm

WIKIPEDIA

GLIMEPIRIDE

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

RS_ITEM_NUM

1292303

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

MERCK INDEX

m5745

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

Merck Index

CAS

93479-97-1

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

LACTMED

Glimepiride

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

FDA UNII

6KY687524K

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

CHEBI

5383

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

SMS_ID

100000085456

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

EVMPD

SUB07925MIG

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

INN

5718

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

DRUG BANK

DB00222

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

NSC

759809

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

IUPHAR

6820

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

DAILYMED

6KY687524K

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

MESH

C057619

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

EPA CompTox

DTXSID5040675

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

USAN

EE-37

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

DRUG CENTRAL

1300

Created by admin on Fri Dec 15 15:51:28 UTC 2023 , Edited by admin on Fri Dec 15 15:51:28 UTC 2023

PRIMARY

Related Record Type Details


					6KY687524K

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

USP

Amount:


					AIN96D6SGL

OATP1B1

TRANSPORTER -> SUBSTRATE

Comments:

Clearance of glimepiridein OATP1B1*5 and *15 was significantly reduced compared to the wild-type.

Amount:


					L9DP834D1P

CYTOCHROME P450 2C9

METABOLIC ENZYME -> SUBSTRATE

Comments:

Clearance of glimepiride CYP2C9*2 and *3 was significantly reduced compared to the wild-type.

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					8RT5G5EY5Z

ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8

TARGET -> INHIBITOR

Amount:


					6KY687524K

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

EP

Amount:

Related Record Type Details


					WVY9QXS57P

HYDROXYGLIMEPIRIDE, TRANS-

METABOLITE LESS ACTIVE -> PARENT

Qualification:

URINE

Amount:

Related Record Type Details


					24T6XIR2MZ

GLIMEPIRIDE, CIS-

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					A72YB30612

GLIMEPIRIDE URETHANE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					24T6XIR2MZ

GLIMEPIRIDE, CIS-

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					612913U5L6

GLIMEPIRIDE SULFONAMIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					612913U5L6

GLIMEPIRIDE SULFONAMIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					757209Q8G8

1-((3-(2-(((3-ETHYL-4-METHYL-2-OXO-2,3-DIHYDRO-1H-PYRROL-1-YL)CARBONYL)AMINO)ETHYL)PHENYL)SULFONYL)-3-(TRANS-4-METHYLCYCLOHEXYL)UREA

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					757209Q8G8

1-((3-(2-(((3-ETHYL-4-METHYL-2-OXO-2,3-DIHYDRO-1H-PYRROL-1-YL)CARBONYL)AMINO)ETHYL)PHENYL)SULFONYL)-3-(TRANS-4-METHYLCYCLOHEXYL)UREA

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

Related Record Type Details


					6KY687524K

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC