CARFILZOMIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C40H57N5O7
Molecular Weight	719.9099
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CARFILZOMIB

Structure Search

SMILES

CC(C)C[C@H](NC(=O)[C@H](CCC1=CC=CC=C1)NC(=O)CN2CCOCC2)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]4(C)CO4

InChI

InChIKey=BLMPQMFVWMYDKT-NZTKNTHTSA-N

InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C40H57N5O7
Molecular Weight	719.9099
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:54:47 UTC 2023` Edited by `admin` on `Fri Dec 15 15:54:47 UTC 2023`
Record UNII	72X6E3J5AR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CARFILZOMIB

Official Name

English

CARFILZOMIB [ORANGE BOOK]

Common Name

English

PR-171

Code

English

NSC-758252

Code

English

L-PHENYLALANINAMIDE, (.ALPHA.S)-.ALPHA.-((4-MORPHOLINYLACETYL)AMINO)BENZENEBUTANOYL-L-LEUCYL-N-((1S)-3-METHYL-1-(((2R)-2-METHYLOXIRANYL)CARBONYL)BUTYL)-

Common Name

English

Carfilzomib [WHO-DD]

Common Name

English

(2S)-N-[(1S)-1-Benzyl-2-[[(1S)-3-methyl-1-[[(2R)-2-methyloxiran-2-yl]carbonyl]butyl]amino]-2-oxoethyl]-4-methyl-2-[[(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide

Common Name

English

KYPROLIS

Brand Name

English

CARFILZOMIB [MI]

Common Name

English

CARFILZOMIB [USAN]

Common Name

English

CARFILZOMIB [VANDF]

Common Name

English

CARFILZOMIB [JAN]

Common Name

English

carfilzomib [INN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

795120

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

NDF-RT

N0000175604

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

FDA ORPHAN DRUG

252507

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

WHO-VATC

QL01XX45

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

EMA ASSESSMENT REPORTS

KYPROLIS (AUTHORIZED: MULTIPLE MYELOMA)

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

EU-Orphan Drug

EU/3/08/548

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

WHO-ATC

L01XX45

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

NCI_THESAURUS

C2160

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

Code System Code Type Description

NCI_THESAURUS

C52196

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

WIKIPEDIA

Carfilzomib

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

CHEBI

65347

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

INN

8859

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

CAS

868540-17-4

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

FDA UNII

72X6E3J5AR

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

DAILYMED

72X6E3J5AR

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

MESH

C524865

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

USAN

SS-92

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

NSC

758252

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

MERCK INDEX

m3107

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

Merck Index

DRUG BANK

DB08889

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

RXCUI

1302966

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

RxNorm

SMS_ID

100000126282

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

EVMPD

SUB32911

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

LACTMED

Carfilzomib

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

EPA CompTox

DTXSID4048690

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

DRUG CENTRAL

4483

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

IUPHAR

7420

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

ChEMBL

CHEMBL451887

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

PUBCHEM

11556711

Created by admin on Fri Dec 15 15:54:47 UTC 2023 , Edited by admin on Fri Dec 15 15:54:47 UTC 2023

PRIMARY

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					7Y3AF186ZB

PROTEASOME SUBUNIT BETA TYPE-9

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MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE


					805SU96HKF

CYTOCHROME P450 3A5

METABOLIC ENZYME -> INHIBITOR

Qualification:

IC50

Amount:


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MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> INHIBITOR

Interaction Type:

WEAK


					M0Z78OYW8Q

PROTEASOME SUBUNIT BETA TYPE-1

TARGET -> INHIBITOR


					T50G13825X

PROTEASOME SUBUNIT BETA TYPE-2

TARGET -> INHIBITOR


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> INHIBITOR

Qualification:

IC50

Amount:


					V2PSF7XPN9

TARGET -> INHIBITOR


					VT5ZQ83U3Q

PROTEASOME SUBUNIT BETA TYPE-5

TARGET -> INHIBITOR

Amount:


					KCI3CU6452

PROTEASOME SUBUNIT BETA TYPE-8

TARGET -> INHIBITOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:

Related Record Type Details


					2R4ADP62TA

(2S)-2-((2-MORPHOLINOACETYL)AMINO)-4-PHENYL-BUTANOIC ACID

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

PLASMA; URINE


					4YMT66EB0I

PR-413

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

PLASMA; URINE


					9C19QCY050

DEEPOXY ETHANE-1,2-DIOL CARFILZOMIB

METABOLITE INACTIVE -> PARENT

Comments:

Cytochrome P450-mediated mechanisms played a minor role in overall carfilzomib metabolism

Interaction Type:

MAJOR

Qualification:

PLASMA

Related Record Type Details


					72X6E3J5AR

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC