AVIBACTAM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C7H11N3O6S
Molecular Weight	265.244
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of AVIBACTAM

Structure Search

SMILES

NC(=O)[C@@H]1CC[C@@H]2C[N@]1C(=O)N2OS(O)(=O)=O

InChI

InChIKey=NDCUAPJVLWFHHB-UHNVWZDZSA-N

InChI=1S/C7H11N3O6S/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15/h4-5H,1-3H2,(H2,8,11)(H,13,14,15)/t4-,5+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C7H11N3O6S
Molecular Weight	265.244
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 20:13:18 UTC 2023` Edited by `admin` on `Fri Dec 15 20:13:18 UTC 2023`
Record UNII	7352665165
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AVIBACTAM

Official Name

English

Avibactam [WHO-DD]

Common Name

English

(1R,2S,5R)-7-OXO-6-SULFOOXY-1,6-DIAZABICYCLO(3.2.1)OCTANE-2-CARBOXAMIDE

Common Name

English

ZAVICEFTA COMPONENT AVIBACTAM

Brand Name

English

SULFURIC ACID, MONO((1R,2S,5R)-2-(AMINOCARBONYL)-7-OXO-1,6-DIAZABICYCLO(3.2.1)OCT-6-YL) ESTER

Common Name

English

AVIBACTAM COMPONENT OF ZAVICEFTA

Brand Name

English

NXL-104 FREE ACID

Code

English

avibactam [INN]

Common Name

English

AVIBACTAM [USAN]

Common Name

English

AVIBACTAM [MI]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000175930

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

Code System Code Type Description

DRUG BANK

DB09060

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

ChEMBL

CHEMBL1689063

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

LACTMED

Ceftazidime and Avibactam

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

WIKIPEDIA

Avibactam

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

INN

8972

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

EVMPD

SUB72111

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

FDA UNII

7352665165

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

PUBCHEM

9835049

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

CAS

1192500-31-4

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

EPA CompTox

DTXSID901026066

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

NCI_THESAURUS

C171777

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

SMS_ID

100000135830

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

RXCUI

1603834

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

RxNorm

DAILYMED

7352665165

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

MERCK INDEX

m2148

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

Merck Index

DRUG CENTRAL

4946

Created by admin on Fri Dec 15 20:13:18 UTC 2023 , Edited by admin on Fri Dec 15 20:13:18 UTC 2023

PRIMARY

Related Record Type Details

7352665165

AVIBACTAM

EXCRETED UNCHANGED

Comments:

An average of 85% of administered avibactam was recovered from the urine as unchanged drug within 96 hours

Qualification:

URINE

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					06MFO7817I

AVE-1330A FREE ACID

RACEMATE -> ENANTIOMER

Amount:

Related Record Type Details


					4VW367W3CM

DESCARBONYL AVIBACTAM

METABOLITE -> PARENT

Qualification:

URINE

Amount:


					C9PUM9D4DT

Avibactam Tomilopil

PRODRUG -> METABOLITE ACTIVE

Amount:

Related Record Type Details

7352665165

AVIBACTAM

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC				MULTIPLE DOSE ADMINISTRATION

Biological Half-life	PHARMACOKINETIC				SINGLE DOSE ADMINISTRATION