ROPIVACAINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H26N2O
Molecular Weight	274.4011
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ROPIVACAINE

Structure Search

SMILES

CCCN1CCCC[C@H]1C(=O)NC2=C(C)C=CC=C2C

InChI

InChIKey=ZKMNUMMKYBVTFN-HNNXBMFYSA-N

InChI=1S/C17H26N2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20)/t15-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C17H26N2O
Molecular Weight	274.4011
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:56:19 UTC 2023` Edited by `admin` on `Sat Dec 16 15:56:19 UTC 2023`
Record UNII	7IO5LYA57N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ROPIVACAINE

Official Name

English

ROPIVACAINE [VANDF]

Common Name

English

TLC590

Code

English

ROPIVACAINE [USP-RS]

Common Name

English

(S)-(-)-1-PROPYLPIPERIDINE-2-CARBOXYLIC ACID (2,6-DIMETHYLPHENYL)AMIDE

Systematic Name

English

TLC-590

Code

English

ROPIVACAINE [MI]

Common Name

English

Ropivacaine [WHO-DD]

Common Name

English

(S)-(-)-1-PROPYL-2',6'-PIPECOLOXYLIDINE

Common Name

English

ropivacaine [INN]

Common Name

English

ROPIVICAINE

Common Name

English

Classification Tree Code System Code

WHO-VATC

QN01BB09

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

NDF-RT

N0000007681

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

NDF-RT

N0000175976

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

NDF-RT

N0000175682

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

WHO-ATC

N01BB09

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

NCI_THESAURUS

C245

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

Code System Code Type Description

MERCK INDEX

m9659

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

Merck Index

RS_ITEM_NUM

1605497

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

EVMPD

SUB10382MIG

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

DAILYMED

7IO5LYA57N

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

EPA CompTox

DTXSID4040187

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

RXCUI

35780

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

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RxNorm

DRUG BANK

DB00296

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

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LACTMED

Ropivacaine

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

INN

5376

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

CHEBI

8890

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

IUPHAR

7602

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

ChEMBL

CHEMBL1077896

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

CAS

84057-95-4

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

FDA UNII

7IO5LYA57N

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

MESH

C037663

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

NCI_THESAURUS

C61932

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

DRUG CENTRAL

2403

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

PUBCHEM

175805

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

SMS_ID

100000084379

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

WIKIPEDIA

ROPIVACAINE

Created by admin on Sat Dec 16 15:56:21 UTC 2023 , Edited by admin on Sat Dec 16 15:56:21 UTC 2023

PRIMARY

Related Record Type Details


					V910P86109

ROPIVACAINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					7IO5LYA57N

EXCRETED UNCHANGED

Qualification:

URINE

Amount:


					MJO2D2C5RI

ROPIVACAINE MESYLATE

SALT/SOLVATE -> PARENT


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE


					35504LBE2T

ROPIVACAINE HYDROCHLORIDE ANHYDROUS

SALT/SOLVATE -> PARENT


					VK4SQL11C0

CYTOCHROME P450 1A2

METABOLIC ENZYME -> SUBSTRATE

Related Record Type Details


					4A8HC6M4AL

2',6'-PIPECOLOXYLIDIDE, (+)-

METABOLITE -> PARENT

Comments:

2% of dose;

Interaction Type:

MINOR

Qualification:

URINE


					R35123T446

4'-HYDROXY-2',6'-PIPECOLOXYLIDIDE

METABOLITE -> PARENT


					UIR389WIVW

2'-HYDROXYMETHYL ROPIVACAINE

METABOLITE -> PARENT

Comments:

Tentatively identified in the urine of some volunteers, accounting fof about 4-15% of the dose

Interaction Type:

MINOR

Qualification:

URINE


					Z6081V395Q

4'-HYDROXYROPIVACAINE

METABOLITE -> PARENT

Comments:

Have a pharmacological activity in animal models less than that of ropivacaine


					L9A41F1FKO

3'-HYDROXYROPIVACAINE

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

URINE


					Z6081V395Q

4'-HYDROXYROPIVACAINE

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

URINE


					4A8HC6M4AL

2',6'-PIPECOLOXYLIDIDE, (+)-

METABOLITE -> PARENT

Comments:

Have a pharmacological activity in animal models less than that of ropivacaine


					L9A41F1FKO

3'-HYDROXYROPIVACAINE

METABOLITE -> PARENT

Comments:

Have a pharmacological activity in animal models less than that of ropivacaine


					2HDS38BFC1

3'-HYDROXY-2',6'-PIPECOLOXYLIDIDE

METABOLITE -> PARENT

Comments:

3% of dose

Interaction Type:

MINOR

Qualification:

URINE

Related Record Type Details


					7IO5LYA57N

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC				INTRAVASCULAR ADMINISTRATION

Biological Half-life	PHARMACOKINETIC				INTRAVASCULAR ADMINISTRATION