LETROZOLE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H11N5
Molecular Weight	285.3027
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of LETROZOLE

Structure Search

SMILES

N#CC1=CC=C(C=C1)C(N2C=NC=N2)C3=CC=C(C=C3)C#N

InChI

InChIKey=HPJKCIUCZWXJDR-UHFFFAOYSA-N

InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H

HIDE SMILES / InChI

Molecular Formula	C17H11N5
Molecular Weight	285.3027
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:41:46 UTC 2023` Edited by `admin` on `Fri Dec 15 15:41:46 UTC 2023`
Record UNII	7LKK855W8I
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

LETROZOLE

Official Name

English

CGS 20267

Code

English

4,4'-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE)DIBENZONITRILE

Systematic Name

English

LETROZOLE [ORANGE BOOK]

Common Name

English

LETROZOLE [USP MONOGRAPH]

Common Name

English

LETROZOLE [USAN]

Common Name

English

FEMARA

Brand Name

English

CGS-20267

Code

English

LETROZOLE COMPONENT OF KISQALI FEMARA CO-PACK

Brand Name

English

KISQALI FEMARA CO-PACK COMPONENT LETROZOLE

Brand Name

English

LETROZOLE [MART.]

Common Name

English

LETROZOLE [USP-RS]

Common Name

English

LETROZOLE [MI]

Common Name

English

LETROZOLE [JAN]

Common Name

English

LETROZOLE [EP IMPURITY]

Common Name

English

LETROZOLE [EP MONOGRAPH]

Common Name

English

Letrozole [WHO-DD]

Common Name

English

BENZONITRILE, 4,4'-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE)BIS-

Systematic Name

English

NSC-759652

Code

English

letrozole [INN]

Common Name

English

LETROZOLE [HSDB]

Common Name

English

Classification Tree Code System Code

LIVERTOX

NBK548381

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

WHO-VATC

QL02BG04

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

NDF-RT

N0000175563

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

WHO-ATC

L02BG04

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

NDF-RT

N0000175080

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

NCI_THESAURUS

C2018

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

Code System Code Type Description

MERCK INDEX

m6772

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

Merck Index

ChEMBL

CHEMBL1444

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

NCI_THESAURUS

C1527

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

RXCUI

72965

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

RxNorm

IUPHAR

5209

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

USAN

EE-48

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

DRUG CENTRAL

1556

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

DRUG BANK

DB01006

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

CAS

112809-51-5

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

CHEBI

6413

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

MESH

C067431

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

SMS_ID

100000092486

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

FDA UNII

7LKK855W8I

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

EPA CompTox

DTXSID4023202

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

WIKIPEDIA

LETROZOLE

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

HSDB

7461

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

DAILYMED

7LKK855W8I

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

PUBCHEM

3902

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

EVMPD

SUB08444MIG

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

RS_ITEM_NUM

1356971

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

LACTMED

Letrozole

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

NSC

759652

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

INN

7118

Created by admin on Fri Dec 15 15:41:46 UTC 2023 , Edited by admin on Fri Dec 15 15:41:46 UTC 2023

PRIMARY

Related Record Type Details


					7LKK855W8I

LETROZOLE

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

EP

Amount:


					246D9TQ2XG

CYTOCHROME P450 2A6

METABOLIC ENZYME -> SUBSTRATE

Amount:


					7LKK855W8I

LETROZOLE

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Amount:


					0M77ZW789J

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B7

METABOLIC ENZYME -> SUBSTRATE

Amount:


					CWT22I5484

CYTOCHROME P450 19A1

TARGET -> INHIBITOR

Comments:

Competitive inhibitor of the aromatase enzyme system; it inhibits the conversion of androgens to estrogens. Inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.

Amount:

Related Record Type Details


					SV3F5P90JR

CGP-4645 GLUCURONIDE

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

URINE

Amount:

Related Record Type Details


					7VSW8QP34K

4,4'-(1H-1,3,4-TRIAZOL-1-YLMETHYLENE)DIBENZONITRILE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					7VSW8QP34K

4,4'-(1H-1,3,4-TRIAZOL-1-YLMETHYLENE)DIBENZONITRILE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					95R62HNG30

4,4',4''-METHANETRIYLTRIBENZONITRILE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					95R62HNG30

4,4',4''-METHANETRIYLTRIBENZONITRILE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

Related Record Type Details


					7LKK855W8I

LETROZOLE

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC