ERDAFITINIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H30N6O2
Molecular Weight	446.5447
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ERDAFITINIB

Structure Search

SMILES

COC1=CC(=CC(OC)=C1)N(CCNC(C)C)C2=CC=C3N=CC(=NC3=C2)C4=CN(C)N=C4

InChI

InChIKey=OLAHOMJCDNXHFI-UHFFFAOYSA-N

InChI=1S/C25H30N6O2/c1-17(2)26-8-9-31(20-10-21(32-4)13-22(11-20)33-5)19-6-7-23-24(12-19)29-25(15-27-23)18-14-28-30(3)16-18/h6-7,10-17,26H,8-9H2,1-5H3

HIDE SMILES / InChI

Molecular Formula	C25H30N6O2
Molecular Weight	446.5447
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:24:38 UTC 2023` Edited by `admin` on `Sat Dec 16 17:24:38 UTC 2023`
Record UNII	890E37NHMV
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ERDAFITINIB

Official Name

English

PAN-FGFR TYROSINE KINASE INHIBITOR JNJ-42756493

Common Name

English

BALVERSA

Brand Name

English

ERDAFITINIB [MI]

Common Name

English

ERDAFITINIB [ORANGE BOOK]

Common Name

English

ERDAFITINIB [JAN]

Common Name

English

erdafitinib [INN]

Common Name

English

ERDAFITINIB [USAN]

Common Name

English

Erdafitinib [WHO-DD]

Common Name

English

JNJ-42756493

Code

English

1,2-ETHANEDIAMINE, N1-(3,5-DIMETHOXYPHENYL)-N2-(1-METHYLETHYL)-N1-(3-(1-METHYL-1H-PYRAZOL-4-YL)-6-QUINOXALINYL)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1967

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

NCI_THESAURUS

C129825

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

Code System Code Type Description

NCI_THESAURUS

C103273

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

DRUG CENTRAL

5327

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

CAS

1346242-81-6

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

WIKIPEDIA

Erdafitinib

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

MERCK INDEX

m12171

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

INN

10147

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

EPA CompTox

DTXSID001027936

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

DAILYMED

890E37NHMV

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

ChEMBL

CHEMBL3545376

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

DRUG BANK

DB12147

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

FDA UNII

890E37NHMV

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

USAN

DE-47

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

RXCUI

2123125

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

CAS

1620332-47-9

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

NO STRUCTURE GIVEN

SMS_ID

100000177214

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

PUBCHEM

67462786

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

LACTMED

Erdafitinib

Created by admin on Sat Dec 16 17:24:39 UTC 2023 , Edited by admin on Sat Dec 16 17:24:39 UTC 2023

PRIMARY

Related Record Type Details


					3F84ING33L

FIBROBLAST GROWTH FACTOR RECEPTOR 4

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					890E37NHMV

EXCRETED UNCHANGED

Qualification:

URINE

Amount:


					NJ44AXW7L9

FIBROBLAST GROWTH FACTOR RECEPTOR 1

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Comments:

primarily to alpha-1-acid glycoprotein.

Interaction Type:

BINDING

Amount:


					S344CKA15F

FIBROBLAST GROWTH FACTOR RECEPTOR 2

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> INHIBITOR

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE

Amount:


					890E37NHMV

EXCRETED UNCHANGED

Qualification:

FECAL

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Comments:

CYP3A4 in the total clearance of erdafitinib is estimated to be 20%.


					L9DP834D1P

CYTOCHROME P450 2C9

METABOLIC ENZYME -> SUBSTRATE

Comments:

Contribution of CYP2C9 to the total clearance of erdafitinib is estimated to be 39%


					L01TYM08QX

FIBROBLAST GROWTH FACTOR RECEPTOR 3

TARGET -> INHIBITOR

Qualification:

IC50

Amount:

Related Record Type Details


					890E37NHMV

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC

Tmax	PHARMACOKINETIC