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Details

Stereochemistry ACHIRAL
Molecular Formula C14H7Cl2NO3
Molecular Weight 308.116
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TAFAMIDIS

SMILES

OC(=O)C1=CC=C2N=C(OC2=C1)C3=CC(Cl)=CC(Cl)=C3

InChI

InChIKey=TXEIIPDJKFWEEC-UHFFFAOYSA-N
InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19)

HIDE SMILES / InChI
Molecular Formula C14H7Cl2NO3
Molecular Weight 308.116
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:06:26 UTC 2023
Edited
by admin
on Sat Dec 16 17:06:26 UTC 2023
Record UNII
8FG9H9D31J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TAFAMIDIS
INN   MART.   USAN   WHO-DD  
USAN   INN  
Official Name English
FX006
Code English
Tafamidis [WHO-DD]
Common Name English
VYNDAMAX
Brand Name English
FX1006
Code English
FX-1006
Code English
2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid
Systematic Name English
6-BENZOXAZOLECARBOXYLIC ACID, 2-(3,5-DICHLOROPHENYL)-
Common Name English
TAFAMIDIS [MART.]
Common Name English
TAFAMIDIS [ORANGE BOOK]
Common Name English
TAFAMIDIS [JAN]
Common Name English
TAFAMIDIS [MI]
Common Name English
FX-1005
Code English
FX-006
Code English
tafamidis [INN]
Common Name English
TAFAMIDIS [USAN]
Common Name English
Classification Tree Code System Code
WHO-ATC N07XX08
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
EU-Orphan Drug EU/3/12/1066
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
WHO-VATC QN07XX08
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
FDA ORPHAN DRUG 220606
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
NCI_THESAURUS C87006
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
Code System Code Type Description
EVMPD
SUB33016
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
MESH
C547076
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
USAN
UU-57
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
DAILYMED
8FG9H9D31J
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
SMS_ID
100000126102
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
EPA CompTox
DTXSID00208185
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
ChEMBL
CHEMBL2103837
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
MERCK INDEX
m11717
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
IUPHAR
8378
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
INN
9094
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
DRUG CENTRAL
4192
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
FDA UNII
8FG9H9D31J
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
RXCUI
1545063
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY RxNorm
DRUG BANK
DB11644
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
CHEBI
78538
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
WIKIPEDIA
TAFAMIDIS
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
NCI_THESAURUS
C84193
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
PUBCHEM
11001318
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
CAS
594839-88-0
Created by admin on Sat Dec 16 17:06:28 UTC 2023 , Edited by admin on Sat Dec 16 17:06:28 UTC 2023
PRIMARY
Related Record Type Details
CYTOCHROME P450 2B6
METABOLIC ENZYME -> INDUCER
tafamidis induced CYP2B6 in vitro with an EC50 of 25 μM.
EC50
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A6
METABOLIC ENZYME -> SUBSTRATE
MINOR
CYTOCHROME P450 3A4
METABOLIC ENZYME -> INDUCER
Tafamidis induced CYP3A4 in vitro with an EC50 of 28 μM.
EC50
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B7
METABOLIC ENZYME -> SUBSTRATE
MINOR
OAT-3
TRANSPORTER -> INHIBITOR
IC50
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A3
METABOLIC ENZYME -> SUBSTRATE
ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2
TRANSPORTER -> INHIBITOR
Tafamidis inhibits BCRP in-vitro.
IC50
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A8
METABOLIC ENZYME -> SUBSTRATE
MINOR
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A9
METABOLIC ENZYME -> SUBSTRATE
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1
METABOLIC ENZYME -> SUBSTRATE
TRANSTHYRETIN
TARGET->STABILIZER
Stabilizes tetrameric form to prevetn the formation of transthyretin amyloidosis.
Structure of TAFAMIDIS MEGLUMINE
SALT/SOLVATE -> PARENT
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A7
METABOLIC ENZYME -> SUBSTRATE
MINOR
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
Related Record Type Details
Structure of TAFAMIDIS
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Tmax PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC
NIH
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