DAPSONE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H12N2O2S
Molecular Weight	248.301
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DAPSONE

Structure Search

SMILES

NC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(N)C=C2

InChI

InChIKey=MQJKPEGWNLWLTK-UHFFFAOYSA-N

InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2

HIDE SMILES / InChI

Molecular Formula	C12H12N2O2S
Molecular Weight	248.301
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:04:08 UTC 2023` Edited by `admin` on `Sat Dec 16 16:04:08 UTC 2023`
Record UNII	8W5C518302
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DAPSONE

Official Name

English

DAPSONE [VANDF]

Common Name

English

ACZONE

Brand Name

English

DAPSONE [WHO-IP]

Common Name

English

NSC-6091

Code

English

dapsone [INN]

Common Name

English

4,4'-SULFONYLDIANILINE

Systematic Name

English

DAPSONE [USP MONOGRAPH]

Common Name

English

DAPSONE [HSDB]

Common Name

English

DAPSONE [EP MONOGRAPH]

Common Name

English

DAPSONE [MART.]

Common Name

English

NOVOPHONE

Common Name

English

DAPSONUM [WHO-IP LATIN]

Common Name

English

DAPSONE [IARC]

Common Name

English

J04BA02

Code

English

DIAPHENYLSULFONE [JAN]

Common Name

English

DIAPHENYLSULFONE

Common Name

English

DAPSONE [EP IMPURITY]

Common Name

English

BENZENAMINE, 4,4'-SULFONYLBIS-

Systematic Name

English

DAPSONE [ORANGE BOOK]

Common Name

English

DAPSONE [MI]

Common Name

English

DAPSONE [USP-RS]

Common Name

English

NSC-6091D

Code

English

SULFACETAMIDE SODIUM IMPURITY D [EP IMPURITY]

Common Name

English

DAPSONE [USAN]

Common Name

English

Dapsone [WHO-DD]

Common Name

English

SERVIDAPSON

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000008053

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

NCI_THESAURUS

C849

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

WHO-VATC

QD10AX05

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

6.2.3

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

WHO-ATC

J04BA02

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

WHO-VATC

QJ04BA02

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

WHO-ATC

D10AX05

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

FDA ORPHAN DRUG

85694

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

NDF-RT

N0000175881

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

NDF-RT

N0000008053

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

FDA ORPHAN DRUG

61291

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

EPA PESTICIDE CODE

690107

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

LIVERTOX

NBK548936

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

FDA ORPHAN DRUG

61191

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

Code System Code Type Description

DAILYMED

8W5C518302

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

HSDB

5073

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

MESH

D003622

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

PUBCHEM

2955

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

EVMPD

SUB06909MIG

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

ChEMBL

CHEMBL1043

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

FDA UNII

8W5C518302

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

CAS

80-08-0

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

RXCUI

3108

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

RxNorm

DRUG CENTRAL

782

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

ECHA (EC/EINECS)

201-248-4

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

MERCK INDEX

m4092

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

Merck Index

SMS_ID

100000083461

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

RS_ITEM_NUM

1164008

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

CHEBI

4325

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

INN

1676

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

WHO INTERNATIONAL PHARMACOPEIA

DAPSONE

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

Description: A white or creamy white, crystalline powder; odourless. Solubility: Soluble in 7000 parts of water and in 30 parts of ethanol (~750 g/l) TS; soluble in acetone R.Category: Antileprotic. Storage: Dapsone should be kept in a tightly closed container, protected from light. Additional information: Even in the absence of light, Dapsone is gradually degraded on exposure to a humid atmosphere, thedecomposition being faster at higher temperatures.

WIKIPEDIA

DAPSONE

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

LACTMED

Dapsone

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

DRUG BANK

DB00250

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

NSC

6091

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

NCI_THESAURUS

C415

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

EPA CompTox

DTXSID4020371

Created by admin on Sat Dec 16 16:04:10 UTC 2023 , Edited by admin on Sat Dec 16 16:04:10 UTC 2023

PRIMARY

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					R17Q1X3RGX

ARYLAMINE N-ACETYLTRANSFERASE 2

METABOLIC ENZYME -> SUBSTRATE

Amount:


					VK4SQL11C0

CYTOCHROME P450 1A2

METABOLIC ENZYME -> SUBSTRATE


					03BYF220B6

CYTOCHROME P450 2E1

METABOLIC ENZYME -> SUBSTRATE

Amount:


					9DX651UO0D

CYTOCHROME P450 1A1

METABOLIC ENZYME -> SUBSTRATE

Amount:


					JQZ6YM58U5

MYELOPEROXIDASE

TARGET -> INHIBITOR

Amount:

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					6O4TT6Q02I

MONOACETYLDAPSONE HYDROXYLAMINE

METABOLITE -> PARENT

Amount:


					GS5815Z51W

DAPSONE HYDROXYLAMINE

PARENT -> METABOLITE

Comments:

We have also shown recently that greater than 90% of dapsone hydroxylation in human liver microsomes is undertaken by cytochrome P4503A4

Qualification:

URINE

Amount:


					A4YKS8ULCN

MONOACETYLDAPSONE

METABOLITE -> PARENT

Qualification:

PLASMA

Amount:


					GS5815Z51W

DAPSONE HYDROXYLAMINE

METABOLITE TOXIC -> PARENT

Comments:

Metabolite known for methaemoglobin formation in man.

Amount:


					8Z632FNN6D

METABOLITE -> PARENT

Qualification:

URINE

Amount:

Related Record Type Details


					A6R43525YO

METHYL CHLORIDE

IMPURITY -> PARENT

Amount:


					4NRT660KJQ

SULFACETAMIDE SODIUM

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					H9L58S7KDK

Bis(4-nitrophenyl) sulfide

IMPURITY -> PARENT

Amount:


					6GGU990BQF

4,4'-THIODIANILINE

IMPURITY -> PARENT

Amount:


					27RFH0GB4R

HYDRAZINE

IMPURITY -> PARENT

Amount:

Related Record Type Details


					8W5C518302

DAPSONE

ACTIVE MOIETY

Amount: