Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H15F3N4O5 |
| Molecular Weight | 436.3414 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[O-][N+](=O)C1=CN2C[C@@H](COC2=N1)OCC3=CC=C(N=C3)C4=CC=C(OC(F)(F)F)C=C4
InChI
InChIKey=ZXSGSFMORAILEY-HNNXBMFYSA-N
InChI=1S/C19H15F3N4O5/c20-19(21,22)31-14-4-2-13(3-5-14)16-6-1-12(7-23-16)10-29-15-8-25-9-17(26(27)28)24-18(25)30-11-15/h1-7,9,15H,8,10-11H2/t15-/m0/s1
| Molecular Formula | C19H15F3N4O5 |
| Molecular Weight | 436.3414 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:36:35 UTC 2023
by
admin
on
Sat Dec 16 11:36:35 UTC 2023
|
| Record UNII |
911T37M2WY
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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Common Name | English | ||
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Code | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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49836057
Created by
admin on Sat Dec 16 11:36:35 UTC 2023 , Edited by admin on Sat Dec 16 11:36:35 UTC 2023
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PRIMARY | |||
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1403987-02-9
Created by
admin on Sat Dec 16 11:36:35 UTC 2023 , Edited by admin on Sat Dec 16 11:36:35 UTC 2023
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NO STRUCTURE GIVEN | |||
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911T37M2WY
Created by
admin on Sat Dec 16 11:36:35 UTC 2023 , Edited by admin on Sat Dec 16 11:36:35 UTC 2023
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PRIMARY | |||
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1257426-19-9
Created by
admin on Sat Dec 16 11:36:35 UTC 2023 , Edited by admin on Sat Dec 16 11:36:35 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
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TARGET ORGANISM->INHIBITOR |
MIC
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
Official Title: A Phase I, Double-Blind, Placebo Controlled, Randomized, Multiple Ascending Dose Study With a Dose Formulation Comparison Cohort to Evaluate the Safety, Tolerability, and Pharmacokinetics of TBA-354 in Healthy Adult Subjects
Purpose: The objective of the study is to evaluate the safety and tolerability of multiple doses of TBA-354 in healthy subjects.
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ACTIVE MOIETY |
TBA-354 MICs and MBCs against M. tuberculosis H37Rv: MIC (replicating) = 0.006 .MU.M, MBC (replicating) = 0.006 .MU.M, LORA (NR) MIC = 0.27 .MU.M, LORA (NR) MBC = 3.4 .MU.M, 4% BSAb MIC (replicating) = 0.011 .MU.M, 10% FBSc MIC (replicating) = 0.012 .MU.M
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ACTIVE MOIETY |
Originator: Global Alliance for TB Drug Development, University of Auckland; Developer: Global Alliance for TB Drug Development; Class: Antitubercular, Nitroimidazole, Oxazine, Pyridine, Small molecule; Mechanism of Action: Undefined mechanism; Orphan Drug Status: No; On Fast track: No; New Molecular Entity: Yes; Highest Development Phase: Phase I for Tuberculosis; Most Recent Events: 19 Nov 2015 Global Alliance for TB Drug Development plans a phase I trial in Healthy volunteers in USA (NCT02606214), 01 Jan 2015 Phase-I clinical trials in Tuberculosis (In volunteers) in USA (PO), 12 Sep 2012 Pharmacodynamics & pharmacokinetics data from preclinical studies in Tuberculosis presented at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC-2012)
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