HALOBETASOL PROPIONATE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H31ClF2O5
Molecular Weight	484.96
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of HALOBETASOL PROPIONATE

Structure Search

SMILES

[H][C@@]12C[C@H](C)[C@](OC(=O)CC)(C(=O)CCl)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C

InChI

InChIKey=BDSYKGHYMJNPAB-LICBFIPMSA-N

InChI=1S/C25H31ClF2O5/c1-5-21(32)33-25(20(31)12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15-,16-,18-,19-,22-,23-,24-,25-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C25H31ClF2O5
Molecular Weight	484.96
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	9 / 9
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:33:49 UTC 2023` Edited by `admin` on `Fri Dec 15 15:33:49 UTC 2023`
Record UNII	91A0K1TY3Z
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HALOBETASOL PROPIONATE

Official Name

English

DUOBRII COMPONENT HALOBETASOL PROPIONATE

Brand Name

English

ULTRAVATE

Brand Name

English

ULOBETASOL PROPIONATE [MART.]

Common Name

English

CGP-14458

Code

English

ULOBETASOL PROPIONATE

Common Name

English

HALOBETASOL PROPIONATE [USAN]

Common Name

English

HALOBETASOL PROPIONATE [USP MONOGRAPH]

Common Name

English

Ulobetasol propionate [WHO-DD]

Common Name

English

CGP-14,458

Code

English

IDP-118 COMPONENT HALOBETASOL PROPIONATE

Common Name

English

HALOBETASOL PROPIONATE COMPONENT OF DUOBRII

Brand Name

English

JEMDEL

Brand Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 21-CHLORO-6,9-DIFLUORO-11-HYDROXY-16-METHYL-17-(1-OXOPROPOXY)-, (6.ALPHA.,11.BETA.,16.BETA.)-

Systematic Name

English

HALOBETASOL PROPIONATE [USP-RS]

Common Name

English

HALOBETASOL PROPIONATE [ORANGE BOOK]

Common Name

English

HALOBETASOL PROPIONATE [VANDF]

Common Name

English

BMY-30056

Code

English

BRYHALI

Brand Name

English

HALOBETASOL PROPIONATE [MI]

Common Name

English

21-Chloro-6α,9-difluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

Code System Code Type Description

MERCK INDEX

m5899

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

PRIMARY

Merck Index

DRUG CENTRAL

1349

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

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WIKIPEDIA

Ulobetasol propionate

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

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RS_ITEM_NUM

1302906

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

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SMS_ID

100000084781

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

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DAILYMED

91A0K1TY3Z

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

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CAS

66852-54-8

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

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DRUG BANK

DB00596

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

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ChEMBL

CHEMBL1200908

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

PRIMARY

USAN

BB-2

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

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EVMPD

SUB05030MIG

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

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PUBCHEM

6918178

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

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EPA CompTox

DTXSID6046636

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

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FDA UNII

91A0K1TY3Z

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

PRIMARY

NCI_THESAURUS

C47553

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

PRIMARY

RXCUI

45318

Created by admin on Fri Dec 15 15:33:49 UTC 2023 , Edited by admin on Fri Dec 15 15:33:49 UTC 2023

PRIMARY

RxNorm

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Comments:

Halobetasol propionate is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins.The initial interaction, however, is due to the drug binding to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes.


					91A0K1TY3Z

HALOBETASOL PROPIONATE

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

USP

Amount:

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Amount:


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IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

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ACTIVE MOIETY

Amount: