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Details

Stereochemistry ABSOLUTE
Molecular Formula C12H21N3O5S3
Molecular Weight 383.507
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BRINZOLAMIDE

SMILES

CCN[C@H]1CN(CCCOC)S(=O)(=O)C2=C1C=C(S2)S(N)(=O)=O

InChI

InChIKey=HCRKCZRJWPKOAR-JTQLQIEISA-N
InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1

HIDE SMILES / InChI
Molecular Formula C12H21N3O5S3
Molecular Weight 383.507
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:12:39 UTC 2023
Edited
by admin
on Sat Dec 16 17:12:39 UTC 2023
Record UNII
9451Z89515
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BRINZOLAMIDE
EMA EPAR   INN   JAN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
SIMBRINZA COMPONENT BRINZOLAMIDE
Brand Name English
BRINZOLAMIDE [ORANGE BOOK]
Common Name English
BRINZOLAMIDE [MI]
Common Name English
BRINZOLAMIDE [MART.]
Common Name English
BRINZOLAMIDE COMPONENT OF AZARGA
Brand Name English
BRINZOLAMIDE [USP MONOGRAPH]
Common Name English
BRINZOLAMIDE [USAN]
Common Name English
BRINZOLAMIDE [USP-RS]
Common Name English
2H-THIENO(3,2-E)-1,2-THIAZINE-6-SULFONAMIDE, 4-(ETHYLAMINO)-3,4-DIHYDRO-2-(3-METHOXYPROPYL)-, 1,1-DIOXIDE, (R)-
Systematic Name English
brinzolamide [INN]
Common Name English
BRINZOLAMIDE [JAN]
Common Name English
BRINZOLAMIDE [VANDF]
Common Name English
Brinzolamide [WHO-DD]
Common Name English
BRINZOLAMIDE [EMA EPAR]
Common Name English
AZARGA COMPONENT BRINZOLAMIDE
Brand Name English
AZOPT
Brand Name English
BRINZOLAMIDE COMPONENT OF SIMBRINZA
Brand Name English
AL-4862
Code English
BRINZOLAMIDE [USP IMPURITY]
Common Name English
NSC-760050
Code English
Classification Tree Code System Code
WHO-ATC S01EC54
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
NDF-RT N0000175517
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
NCI_THESAURUS C29577
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
EMA ASSESSMENT REPORTS SIMBRINZA (AUTHORIZED: GLAUCOMA, OPEN-ANGLE
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
EMA ASSESSMENT REPORTS AZARGA (AUTHORIZED: OCULAR HYPERTENSION)
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
NDF-RT N0000000235
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
EMA ASSESSMENT REPORTS AZOPT (AUTHORIZED: OCULAR HYPERTENSION)
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
EMA ASSESSMENT REPORTS SIMBRINZA (AUTHORIZED: OCULAR HYPERTENSION)
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
WHO-VATC QS01EC04
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
WHO-ATC S01EC04
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
EMA ASSESSMENT REPORTS AZARGA (AUTHORIZED: GLAUCOMA, OPEN-ANGLE)
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
NCI_THESAURUS C29705
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
EMA ASSESSMENT REPORTS AZOPT (AUTHORIZED: GLAUCOMA, OPEN-ANGLE)
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
Code System Code Type Description
NCI_THESAURUS
C47420
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
MERCK INDEX
m2652
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY Merck Index
RS_ITEM_NUM
1076363
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
MESH
C111827
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
USAN
II-13
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
ChEMBL
CHEMBL220491
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
INN
7532
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
EPA CompTox
DTXSID6045531
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
PUBCHEM
68844
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
CAS
138890-62-7
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
IUPHAR
6797
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
RXCUI
194881
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY RxNorm
CHEBI
3176
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
SMS_ID
100000085244
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
NSC
760050
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
DAILYMED
9451Z89515
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
EVMPD
SUB05892MIG
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
DRUG CENTRAL
396
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
LACTMED
Brinzolamide
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
WIKIPEDIA
BRINZOLAMIDE
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
DRUG BANK
DB01194
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
FDA UNII
9451Z89515
Created by admin on Sat Dec 16 17:12:41 UTC 2023 , Edited by admin on Sat Dec 16 17:12:41 UTC 2023
PRIMARY
Related Record Type Details
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
Structure of BRINZOLAMIDE, (S)-
ENANTIOMER -> ENANTIOMER
CARBONIC ANHYDRASE 2
TARGET -> INHIBITOR
Related Record Type Details
Structure of O-DESMETHYL-BRINZOLAMIDE
METABOLITE -> PARENT
URINE
Structure of N-DESETHYL-BRINZOLAMIDE
METABOLITE ACTIVE -> PARENT
IC50 (CAII): 1.28 nM; IC50 (CAIV): 128 nM
BINDING
IC50
Structure of N-DESMETHOXYPROPYL-BRINZOLAMIDE
METABOLITE -> PARENT
URINE
Related Record Type Details
Structure of 4-DESETHYLAMINO 4-OXOBRINZOLAMIDE
IMPURITY -> PARENT
Structure of 4-HYDROXY-2-(3-METHOXYPROPYL)-3,4-DIHYDRO-2H-THIENO(3,2-E)(1,2)THIAZINE-6-SULFONAMIDE 1,1-DIOXIDE, (S)-
IMPURITY -> PARENT
Structure of N-DESETHYL-BRINZOLAMIDE
IMPURITY -> PARENT
International patent application: WO2013168186
Related Record Type Details
Structure of BRINZOLAMIDE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
NIH
NCATS
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