OXYMORPHONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H19NO4
Molecular Weight	301.3371
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CN1CC[C@@]23[C@H]4OC5=C2C(C[C@@H]1[C@]3(O)CCC4=O)=CC=C5O

InChI

InChIKey=UQCNKQCJZOAFTQ-ISWURRPUSA-N

InChI=1S/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C17H19NO4
Molecular Weight	301.3371
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical
Record UNII	9VXA968E0C
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

OXYMORPHONE

Official Name

English

OXYMORPHONE CII [USP-RS]

Common Name

English

OXYCODONE HYDROCHLORIDE IMPURITY A [EP IMPURITY]

Common Name

English

4,5.ALPHA.-EPOXY-3,14-DIHYDROXY-17-METHYLMORPHINAN-6-ONE

Systematic Name

English

NIH 10323

Code

English

Showing 1 to 5 of 17 entries

Previous1 2 3 4Next

Show entries

Classification Tree

Code System

Code

Established Pharmacologic Class

NDF-RT

N0000175690

Agent Affecting Nervous System

NCI_THESAURUS

C67413

Moderate pain

LIVERTOX

NBK548775

Opioid Agonists

NDF-RT

N0000175684

Alkaloid

NCI_THESAURUS

C1506

Showing 1 to 5 of 7 entries

Previous1 2Next

Show entries

Code System

Code

Type

Description

HSDB

8060

PRIMARY

RXCUI

7814

PRIMARY

RxNorm

NCI_THESAURUS

C29314

PRIMARY

PUBCHEM

5284604

PRIMARY

NSC

19045

PRIMARY

Showing 1 to 5 of 22 entries

Previous1 2 3 4 5Next

Show entries

Related Record

Type

Details


					5Y2EI94NBC

OXYMORPHONE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:

RELATIONSHIP_AMOUNT 89 (average)


					KM542GS55Z

OXYMORPHONE HYDROBROMIDE

SALT/SOLVATE -> PARENT

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:

[10 to 12] % (average)


					CV52YZ5G1X

OXYMORPHONE HYDROCHLORIDE MONOHYDRATE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:

RELATIONSHIP_AMOUNT 85 (average)


					SYR9B86WW7

OXYMORPHONE HYDRIODIDE

SALT/SOLVATE -> PARENT

Amount:

Showing 1 to 5 of 5 entries

Previous1Next

Show entries

Related Record

Type

Details


					1O00P9X5C1

HYDROMORPHINOL

METABOLITE -> PARENT

Comments:

6-OH-oxymorphone has been shown in animal studies to have analgesic bioactivity

Interaction Type:

MAJOR

Qualification:

PLASMA; URINE


					CS1J30867C

OXYMORPHONE 3-GLUCURONIDE

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

PLASMA


					CD35PMG570

OXYCODONE

PARENT -> METABOLITE ACTIVE

Comments:

Highly variable 40 fold higher potency than Oxycodone

Interaction Type:

MINOR

Qualification:

PLASMA; URINE

Amount:

RELATIONSHIP_AMOUNT 10 MOLE PERCENT (average)


					67P6D5Q6YK

6.BETA.-OXYMORPHOL

METABOLITE -> PARENT

Comments:

6-OH-oxymorphone has been shown in animal studies to have analgesic bioactivity.

Interaction Type:

MAJOR

Qualification:

URINE

Showing 1 to 4 of 4 entries

Previous1Next

Show entries

Related Record

Type

Details


					C1ENJ2TE6C

OXYCODONE HYDROCHLORIDE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

RELATIONSHIP_AMOUNT [<0.15] PERCENT PEAK AREA (limits)

Showing 1 to 1 of 1 entries

Previous1Next

Show entries

Related Record

Type

Details


					9VXA968E0C

OXYMORPHONE

ACTIVE MOIETY

Showing 1 to 1 of 1 entries

Previous1Next

Name	Property Type	Amount	Parameters
Biological Half-life	PHARMACOKINETIC	[0.6 to 2] hours (average)	Elimination PHARMACOKINETIC Oral; Extended Release [9 to 11] hours (average) Elimination PHARMACOKINETIC Oral; Immediate Release [7 to 9] hours (average)

Volume of Distribution	PHARMACOKINETIC	[1.94 to 4.22] Liters/Kilogram (average)