PRALATREXATE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	EPIMERIC
Molecular Formula	C23H23N7O5
Molecular Weight	477.4726
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PRALATREXATE

Structure Search

SMILES

NC1=NC(N)=C2N=C(CC(CC#C)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=NC2=N1

InChI

InChIKey=OGSBUKJUDHAQEA-WMCAAGNKSA-N

InChI=1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,28,33)(H,31,32)(H,34,35)(H4,24,25,26,29,30)/t14?,16-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C23H23N7O5
Molecular Weight	477.4726
Charge	0
Count

Stereochemistry	EPIMERIC
Additional Stereochemistry	No
Defined Stereocenters	1 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:41:58 UTC 2023` Edited by `admin` on `Sat Dec 16 10:41:58 UTC 2023`
Record UNII	A8Q8I19Q20
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PRALATREXATE

Official Name

English

PRALATREXATE [MI]

Common Name

English

PRALATREXATE [JAN]

Common Name

English

PDX

Common Name

English

Pralatrexate [WHO-DD]

Common Name

English

PRALATREXATE [ORANGE BOOK]

Common Name

English

NSC-754230

Code

English

(2S)-2-[[4-[(1RS)-1-[(2,4-Diaminopteridin-6-yl)methyl]but-3-ynyl]benzoyl]amino]pentanedioic acid

Systematic Name

English

PRALATREXATE [USAN]

Common Name

English

L-GLUTAMIC ACID, N-(4-(1-((2,4-DIAMINO-6-PTERIDINYL)METHYL)-3-BUTYNYL)BENZOYL)-

Systematic Name

English

PRALATREXATE [HSDB]

Common Name

English

PRALATREXATE [MART.]

Common Name

English

PRALATREXATE [VANDF]

Common Name

English

FOLOTYN

Brand Name

English

pralatrexate [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C511

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

EU-Orphan Drug

EU/3/07/444

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

NDF-RT

N0000175584

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

FDA ORPHAN DRUG

260708

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

LIVERTOX

NBK547901

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

NCI_THESAURUS

C2153

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

FDA ORPHAN DRUG

268308

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

WHO-ATC

L01BA05

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

FDA ORPHAN DRUG

225306

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

WHO-VATC

QL01BA05

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

FDA ORPHAN DRUG

269008

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

EMA ASSESSMENT REPORTS

FOLOTYN (REFUSED: LYMPHOMA, T-CELL)

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

Code System Code Type Description

RXCUI

662019

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

RxNorm

NCI_THESAURUS

C2250

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

DRUG BANK

DB06813

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

CAS

146464-95-1

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

HSDB

7786

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

CHEBI

71223

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

SMS_ID

100000126312

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

DAILYMED

A8Q8I19Q20

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

USAN

QQ-31

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

ChEMBL

CHEMBL1201746

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

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EPA CompTox

DTXSID3048578

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

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MERCK INDEX

m9091

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

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Merck Index

MESH

C418863

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

DRUG CENTRAL

4117

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

INN

8560

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

PUBCHEM

148121

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

NSC

754230

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

WIKIPEDIA

PRALATREXATE

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

IUPHAR

6840

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

EVMPD

SUB32989

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

FDA UNII

A8Q8I19Q20

Created by admin on Sat Dec 16 10:41:59 UTC 2023 , Edited by admin on Sat Dec 16 10:41:59 UTC 2023

PRIMARY

Related Record Type Details


					5T4JAQ7QVD

DIHYDROFOLATE REDUCTASE

TARGET -> INHIBITOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					D79B6ADG1E

THYMIDYLATE SYNTHASE

TARGET -> INHIBITOR

Related Record Type Details


					A8Q8I19Q20

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC