AMANTADINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H17N
Molecular Weight	151.2487
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of AMANTADINE

Structure Search

SMILES

NC12CC3CC(CC(C3)C1)C2

InChI

InChIKey=DKNWSYNQZKUICI-UHFFFAOYSA-N

InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2

HIDE SMILES / InChI

Molecular Formula	C10H17N
Molecular Weight	151.2487
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:15:12 UTC 2023` Edited by `admin` on `Fri Dec 15 15:15:12 UTC 2023`
Record UNII	BF4C9Z1J53
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AMANTADINE

Official Name

English

GOCOVRI

Brand Name

English

AMANTADINE [MI]

Common Name

English

AMANTADINE [MART.]

Common Name

English

AMANTADINE [VANDF]

Common Name

English

ADAMANTAN-1-AMINE

Systematic Name

English

amantadine [INN]

Common Name

English

NSC-341865

Code

English

AMANTIDINE

Common Name

English

Amantadine [WHO-DD]

Common Name

English

AMANTADINE [HSDB]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C93038

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

NCI_THESAURUS

C281

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

NDF-RT

N0000175542

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

NCI_THESAURUS

C38149

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

WHO-ATC

N04BB01

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

NDF-RT

N0000175543

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

WHO-VATC

QN04BB01

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

LIVERTOX

NBK547954

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

Code System Code Type Description

FDA UNII

BF4C9Z1J53

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

EPA CompTox

DTXSID8022117

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

IUPHAR

4128

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

NSC

341865

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

RXCUI

620

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

RxNorm

DRUG CENTRAL

144

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

EVMPD

SUB05389MIG

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

MESH

D000547

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

SMS_ID

100000087646

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

INN

1816

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

CHEBI

2618

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

CAS

768-94-5

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

PUBCHEM

2130

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

LACTMED

Amantadine

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

DAILYMED

BF4C9Z1J53

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

WIKIPEDIA

AMANTADINE

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

ChEMBL

CHEMBL660

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

HSDB

3202

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

NCI_THESAURUS

C61632

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

DRUG BANK

DB00915

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

ECHA (EC/EINECS)

212-201-2

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

MERCK INDEX

m1638

Created by admin on Fri Dec 15 15:15:13 UTC 2023 , Edited by admin on Fri Dec 15 15:15:13 UTC 2023

PRIMARY

Merck Index

Related Record Type Details


					1314JZ2X6W

INFLUENZA B VIRUS WHOLE

TARGET ORGANISM->INHIBITOR

Amount:


					482M00274D

OCT-2

TRANSPORTER -> SUBSTRATE


					ONY583280Z

OCT-1

TRANSPORTER -> SUBSTRATE


					9921T5P019

AMANTADINE SULFATE

SALT/SOLVATE -> PARENT

Amount:


					BF4C9Z1J53

EXCRETED UNCHANGED

Comments:

Amantadine is primarily excreted unchanged in the urine, and in a study of six healthy volunteers, the ratio of amantadine renal clearance to apparent plasma clearance was 0.79 ± 0.17 (mean ± SD).

Amount:


					ONY583280Z

OCT-1

TRANSPORTER -> INHIBITOR


					B46KUN2O9L

MATE-2

TRANSPORTER -> INHIBITOR


					482M00274D

OCT-2

TRANSPORTER -> INHIBITOR


					M6Q1EO9TD0

AMANTADINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					6NP3XSMIP3

MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1

TRANSPORTER -> INHIBITOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					R9HH0NDE2E

INFLUENZA A VIRUS WHOLE

TARGET ORGANISM->INHIBITOR

Amount:


					4007E25Z4Z

OCT-3

TRANSPORTER -> INHIBITOR


					3OV8HVI592

AMINE OXIDASE (FLAVIN-CONTAINING) B

METABOLIC ENZYME -> INHIBITOR

Amount:

Related Record Type Details


					5283Y1VOII

N-ADAMANTYLACETAMIDE

METABOLITE -> PARENT

Qualification:

URINE

Amount:

Related Record Type Details


					BF4C9Z1J53

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC

Tmax	PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC