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Details

Stereochemistry ABSOLUTE
Molecular Formula C24H34O4
Molecular Weight 386.5244
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEDROXYPROGESTERONE ACETATE

SMILES

[H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])C[C@H](C)C4=CC(=O)CC[C@]34C

InChI

InChIKey=PSGAAPLEWMOORI-PEINSRQWSA-N
InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1

HIDE SMILES / InChI
Molecular Formula C24H34O4
Molecular Weight 386.5244
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 7 / 7
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:00:43 UTC 2023
Edited
by admin
on Fri Dec 15 15:00:43 UTC 2023
Record UNII
C2QI4IOI2G
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MEDROXYPROGESTERONE ACETATE
EP   JAN   MART.   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
Common Name English
DEPOT-MEDROXYPROGESTERONE ACETATE
Common Name English
17-Hydroxy-6α-methylpregn-4-ene-3,20-dione acetate
Common Name English
PREGN-4-ENE-3,20-DIONE, 17-(ACETYLOXY)-6-METHYL-, (6.ALPHA.)-
Systematic Name English
MEDROXYPROGESTERONE 17-ACETATE
MI  
Common Name English
MEDROXYPROGESTERONE ACETATE [USP MONOGRAPH]
Common Name English
AMEN
Brand Name English
CURRETAB
Brand Name English
MEDROXYPROGESTERONE ACETATE [WHO-IP]
Common Name English
MEGESTROL ACETATE IMPURITY A [EP IMPURITY]
Common Name English
MEDROXYPROGESTERONE ACETATE [MART.]
Common Name English
MEDROXYPROGESTERONE ACETATE [ORANGE BOOK]
Common Name English
DEPO-SUBQ PROVERA 104
Brand Name English
MEDROXYPROGESTERONE ACETATE [IARC]
Common Name English
MEDROXYPROGESTERONE ACETATE COMPONENT OF LUNELLE
Common Name English
MEDROXYPROGESTERONE 17-ACETATE [MI]
Common Name English
TV-46046
Code English
PREMPHASE COMPONENT MEDROXYPROGESTERONE ACETATE
Brand Name English
MEDROXYPROGESTERONE ACETATE COMPONENT OF PREMPHASE
Brand Name English
NSC-21171
Code English
DMPA
Common Name English
PROVERA
Brand Name English
MEDROXYPROGESTERONE ACETATE [VANDF]
Common Name English
MEDROXYPROGESTERONI ACETAS [WHO-IP LATIN]
Common Name English
LUNELLE COMPONENT MEDROXYPROGESTERONE ACETATE
Common Name English
MEDROXYPROGESTERONE ACETATE [USP-RS]
Common Name English
NSC-26386
Code English
MEDROXYPROGESTERONE ACETATE [JAN]
Common Name English
MEDROXYPROGESTERONE ACETATE [EP MONOGRAPH]
Common Name English
CYCRIN
Brand Name English
PREMPRO COMPONENT MEDROXYPROGESTERONE ACETATE
Brand Name English
DEPO-PROVERA
Brand Name English
MEDROXYPROGESTERONE ACETATE COMPONENT OF PREMPRO
Brand Name English
Medroxyprogesterone acetate [WHO-DD]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 141901
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
IARC Medroxyprogesterone acetate
WHO-ESSENTIAL MEDICINES LIST 18.3.2
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
WHO-ESSENTIAL MEDICINES LIST 18.7
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
NCI_THESAURUS C776
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
WHO-ESSENTIAL MEDICINES LIST 18.3.2 (EST/MED)
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
Code System Code Type Description
NSC
21171
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
MEDROXYPROGESTERONE ACETATE
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY Description: A white or almost white, crystalline powder. Solubility: Practically insoluble in water; soluble in acetone R and dioxan R; slightly soluble in ethanol (~750 g/L) TS, methanol Rand ether R. Category: Progestogen. Storage: Medroxyprogesterone acetate should be kept in a tight container, protected from light. Definition: Medroxyprogesterone acetate contains not less than 97.0% and not more than the equivalent of 103.0% of C24H34O4,calculated with reference to the dried substance.
RXCUI
1000112
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY RxNorm
ALANWOOD
DMPA
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY
MESH
D017258
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY
NSC
26386
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY
EVMPD
SUB03114MIG
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY
CAS
71-58-9
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY
EVMPD
SUB127224
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
ALTERNATIVE
FDA UNII
C2QI4IOI2G
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY
DAILYMED
C2QI4IOI2G
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY
DRUG BANK
DB00603
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY
CHEBI
6716
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY
NCI_THESAURUS
C1155
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY
SMS_ID
100000091612
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
MERCK INDEX
m7134
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY Merck Index
WIKIPEDIA
MEDROXYPROGESTERONE ACETATE
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-757-9
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY
RS_ITEM_NUM
1378001
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
ChEMBL
CHEMBL717
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY
EPA CompTox
DTXSID0025527
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY
PUBCHEM
6279
Created by admin on Fri Dec 15 15:00:44 UTC 2023 , Edited by admin on Fri Dec 15 15:00:44 UTC 2023
PRIMARY
LACTMED
Medroxyprogesterone Acetate
Created by admin on Fri Dec 15 15:00:43 UTC 2023 , Edited by admin on Fri Dec 15 15:00:43 UTC 2023
PRIMARY
Related Record Type Details
Structure of MEDROXYPROGESTERONE ACETATE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (UV)
EP
Structure of MEDROXYPROGESTERONE ACETATE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
Related Record Type Details
Structure of 6-METHYLENEHYDROXYPROGESTERONE ACETATE
IMPURITY -> PARENT
MEDROXYPROGESTERONE ACETATE Impurity E. In the chromatogram obtained with solution (1):the area of any peak corresponding to impurity C, E or I is not greater than 2 times the area of the principal peak obtained with solution (3) (0.2%).
Structure of HYDROXYPROGESTERONE ACETATE
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of 6.ALPHA.,17A.BETA.-DIMETHYL-3,17-DIOXO-D-HOMOPREGN-4-EN-17A.ALPHA.-YL ACETATE
IMPURITY -> PARENT
The following peaks are eluted at the following relative retention with reference to the peak of medroxyprogesterone acetate (retention time about 27 minutes): impurity C about 0.8. The test is not valid unless in the chromatogram obtained with solution (4) the resolution factor between the peaks due to impurity G and due to medroxyprogesterone acetate is at least 3.3. In the chromatogram obtained with solution (1):the area of any peak corresponding to impurity C, E or I is not greater than 2 times the area of the principal peak obtained with solution (3) (0.2%).
Structure of 6-METHYLENEHYDROXYPROGESTERONE ACETATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 17aβ-Hydroxy-6α,17aα-dimethyl-D-homoandrost-4-ene-3-17-dione
IMPURITY -> PARENT
MEDROXYPROGESTERONE ACETATE Impurity I. The following peaks are eluted at the following relative retention with reference to the peak of medroxyprogesterone acetate (retention time about 27 minutes): impurity I about 0.5. In the chromatogram obtained with solution (1):the area of any peak corresponding to impurity C, E or I is not greater than 2 times the area of the principal peak obtained with solution (3) (0.2%).
Structure of 6-HYDROXYMEDROXYPROGESTERONE ACETATE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.5
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of MEGESTROL ACETATE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 2.6
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 4,5-DIHYDROMEDROXYPROGESTERONE ACETATE
IMPURITY -> PARENT
MEDROXYPROGESTERONE ACETATE Impurity F. Amount not specified.
Structure of HYDROXYPROGESTERONE ACETATE
IMPURITY -> PARENT
MEDROXYPROGESTERONE ACETATE Impurity H. The following peaks are eluted at the following relative retention with reference to the peak of medroxyprogesterone acetate (retention time about 27 minutes): impurity H about 0.65.
Structure of 4,5-DIHYDROMEDROXYPROGESTERONE ACETATE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.8
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 6-EPIMEDROXYPROGESTERONE ACETATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of MEDROXYPROGESTERONE
IMPURITY -> PARENT
MEDROXYPROGESTERONE ACETATE Impurity B. In the chromatogram obtained with solution (1):the area of any peak corresponding to impurity B is not greater than 0.7 times the area of the principal peak obtained with solution (2) (0.7%).
Structure of 17A.BETA.-HYDROXY-6,17A-DIMETHYL-D-HOMOANDROST-4-ENE-3,17-DIONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of MEGESTROL ACETATE
IMPURITY -> PARENT
MEDROXYPROGESTERONE ACETATE Impurity G. In the chromatogram obtained with solution (1):the area of any peak corresponding to impurity G, when multiplied by a correction factor of 2.6, is not greater than 2 times of the area of the principal peak obtained with solution (3) (0.2%).
Structure of MEGESTROL ACETATE
PARENT -> IMPURITY
For the calculation of contents, multiply the peak areas by 0.2
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 6-EPIMEDROXYPROGESTERONE ACETATE
IMPURITY -> PARENT
MEDROXYPROGESTERONE ACETATE Impurity D. In the chromatogram obtained with solution (1):the area of any peak corresponding to impurity D is not greater than the area of the principal peak obtained with solution (2) (1.0%).
Structure of MEDROXYPROGESTERONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 6-HYDROXYMEDROXYPROGESTERONE ACETATE
IMPURITY -> PARENT
MEDROXYPROGESTERONE ACETATE Impurity A. In the chromatogram obtained with solution (1):the area of any peak corresponding to impurity A, when multiplied by a correction factor of 1.5, is not greater than 3 times of the area of the principal peak obtained with solution (3) (0.3%).
Structure of 6.ALPHA.,17A-DIMETHYL-3,17-DIOXO-D-HOMOANDROST-4-EN-17A.ALPHA.-YL ACETATE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of MEDROXYPROGESTERONE
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