ARBUTIN

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H16O7
Molecular Weight	272.2512
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ARBUTIN

Structure Search

SMILES

OC[C@H]1O[C@@H](OC2=CC=C(O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O

InChI

InChIKey=BJRNKVDFDLYUGJ-RMPHRYRLSA-N

InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C12H16O7
Molecular Weight	272.2512
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:20:32 UTC 2023` Edited by `admin` on `Fri Dec 15 15:20:32 UTC 2023`
Record UNII	C5INA23HXF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ARBUTIN

Official Name

English

ARBUTINUM [HPUS]

Common Name

English

ARBUTIN [HSDB]

Common Name

English

Arbutin [WHO-DD]

Common Name

English

HYDROQUINONE GLUCOSE

Systematic Name

English

ARBUTIN [MI]

Common Name

English

HYDROQUINONE-.BETA.-D-GLUCOPYRANOSIDE

Common Name

English

ARBUTOSIDE

Common Name

English

4-HYDROXYPHENYL-.BETA.-D-GLUCOPYRANOSIDE

Common Name

English

NSC-4036

Code

English

ARBUTIN [MART.]

Common Name

English

ARBUTIN [INCI]

Common Name

English

URSIN

Common Name

English

ARBUTINUM

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C471

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

DSLD

1289 (Number of products:3)

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

Code System Code Type Description

DRUG BANK

DB11217

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

MERCK INDEX

m2033

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

Merck Index

ECHA (EC/EINECS)

207-850-3

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

HSDB

7661

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

FDA UNII

C5INA23HXF

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

CAS

497-76-7

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

EVMPD

SUB33412

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

DAILYMED

C5INA23HXF

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

NCI_THESAURUS

C87429

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

EPA CompTox

DTXSID7040152

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

CHEBI

18305

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

DRUG CENTRAL

4267

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

SMS_ID

100000126183

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

RXCUI

1367175

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

RxNorm

NSC

4036

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

PUBCHEM

440936

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

WIKIPEDIA

ARBUTIN

Created by admin on Fri Dec 15 15:20:32 UTC 2023 , Edited by admin on Fri Dec 15 15:20:32 UTC 2023

PRIMARY

Related Record Type Details


					3M5V3D1X36

ARCTOSTAPHYLOS UVA-URSI LEAF

PARENT -> CONSTITUENT ALWAYS PRESENT

Interaction Type:

ASSAY (HPLC)

Amount:

Related Record Type Details


					P938AXP4T2

HYDROQUINONE MONOSULFATE

METABOLITE -> PARENT

Comments:

Unit: mg (calculated as arbutin); Urinary elimination profiles of arbutin metabolites (150mg arbutin in about 150mL aqueous bearberry leaf extract oral q.i.d., n=3, 16-24hr urine)

Interaction Type:

IN-VIVO

Qualification:

URINE

Amount:


					XV74C1N1AE

METABOLITE -> PARENT

Comments:

Unit: mg (calculated as arbutin); 150mg arbutin in about 150mL aqueous bearberry leaf extract, q.i.d.; 0-24hr urine; n=3

Interaction Type:

IN-VIVO

Qualification:

URINE

Amount:


					XV74C1N1AE

METABOLITE -> PARENT

Comments:

Amount excreted in urine within the 36-hour study period, 945mg bearberry leaf extract (corresponding to 210mg arbutin, in two film coated tabs) single oral administration, n=16 (8 female, 8 male), 0-36hr urine

Interaction Type:

IN-VIVO

Qualification:

URINE

Amount:


					P938AXP4T2

HYDROQUINONE MONOSULFATE

METABOLITE -> PARENT

Comments:

Amount excreted in urine within the 36-hour period, 945mg bearberry leaf dry extract (210mg arbutin equivalent, in aqueous solution) single oral administration, n=16 (8 female, 8 male)

Interaction Type:

IN-VIVO

Qualification:

URINE

Amount:


					7UQ83N5MHX

QUINOL GLUCURONIDE

METABOLITE -> PARENT

Comments:

Unit: mg; Amount excreted in urine within 36-hr study period, Bearberry leaves dry extract(BLDE) 945mg single oral administration(210mg arbutin correspondence, in 2 film coated tabs, each contained 472.5mg BLDE or 105mg arbutin), n=16 (8 female & 8 male)

Interaction Type:

IN-VIVO

Qualification:

URINE

Amount:


					7UQ83N5MHX

QUINOL GLUCURONIDE

METABOLITE -> PARENT

Comments:

945mg bear berry leaf extract (w/210mg arbutin) single oral administration, 0-4hr urine, n=1

Interaction Type:

IN-VIVO

Qualification:

URINE

Amount:


					7UQ83N5MHX

QUINOL GLUCURONIDE

METABOLITE -> PARENT

Comments:

Unit: mg; Amount excreted in urine within 36-hr study period, Bearberry leaves dry extract(BLDE) 945mg single oral administration(210mg arbutin correspondence, aqueous solution), n=16 (8 female & 8 male)

Interaction Type:

IN-VIVO

Qualification:

URINE

Amount:


					P938AXP4T2

HYDROQUINONE MONOSULFATE

METABOLITE -> PARENT

Comments:

Amount excreted in urine within the 36-hour period, 945mg bearberry leaf dry extract (210mg arbutin equivalent, in two film coated tabs) single oral administration, n=16 (8 female, 8 male)

Interaction Type:

IN-VIVO

Qualification:

URINE

Amount:


					7UQ83N5MHX

QUINOL GLUCURONIDE

METABOLITE -> PARENT

Comments:

Unit: mg calculated as arbutin; Urinary elimination of arbutin metabolites (16-24hr urine, n=3, 150mg arubutin in about 150mL aqueous bearberry leaf extract, q.i.d.)

Interaction Type:

IN-VIVO

Qualification:

URINE

Amount:


					XV74C1N1AE

METABOLITE -> PARENT

Interaction Type:

IN-VIVO

Qualification:

URINE

Amount:

Related Record Type Details


					C5INA23HXF

ARBUTIN

ACTIVE MOIETY