Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C72H116N20O19 |
| Molecular Weight | 1565.814 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 13 / 13 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
InChI
InChIKey=LGANPTNILMNMES-TVNHODDRSA-N
InChI=1S/C72H116N20O19/c1-39(2)31-48(84-63(102)49(33-42-17-8-7-9-18-42)85-60(99)46(24-25-56(94)95)81-59(98)44(75)19-10-12-26-73)62(101)88-52(34-43-36-78-38-80-43)70(109)92-30-16-23-55(92)67(106)89-53(37-93)65(104)82-45(20-11-13-27-74)61(100)90-58(41(5)6)68(107)86-50(35-57(96)97)64(103)87-51(32-40(3)4)69(108)91-29-15-22-54(91)66(105)83-47(71(110)111)21-14-28-79-72(76)77/h7-9,17-18,36,38-41,44-55,58,93H,10-16,19-35,37,73-75H2,1-6H3,(H,78,80)(H,81,98)(H,82,104)(H,83,105)(H,84,102)(H,85,99)(H,86,107)(H,87,103)(H,88,101)(H,89,106)(H,90,100)(H,94,95)(H,96,97)(H,110,111)(H4,76,77,79)/t44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,58-/m0/s1
| Molecular Formula | C72H116N20O19 |
| Molecular Weight | 1565.814 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 13 / 13 |
| E/Z Centers | 4 |
| Optical Activity | UNSPECIFIED |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:29:01 UTC 2023
by
admin
on
Sat Dec 16 11:29:01 UTC 2023
|
| Record UNII |
C79B5A73C4
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
526016
Created by
admin on Sat Dec 16 11:29:01 UTC 2023 , Edited by admin on Sat Dec 16 11:29:01 UTC 2023
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FDA ORPHAN DRUG |
505215
Created by
admin on Sat Dec 16 11:29:01 UTC 2023 , Edited by admin on Sat Dec 16 11:29:01 UTC 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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C101525
Created by
admin on Sat Dec 16 11:29:01 UTC 2023 , Edited by admin on Sat Dec 16 11:29:01 UTC 2023
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PRIMARY | |||
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1187852-48-7
Created by
admin on Sat Dec 16 11:29:01 UTC 2023 , Edited by admin on Sat Dec 16 11:29:01 UTC 2023
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PRIMARY | |||
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DB15366
Created by
admin on Sat Dec 16 11:29:01 UTC 2023 , Edited by admin on Sat Dec 16 11:29:01 UTC 2023
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PRIMARY | |||
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C79B5A73C4
Created by
admin on Sat Dec 16 11:29:01 UTC 2023 , Edited by admin on Sat Dec 16 11:29:01 UTC 2023
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PRIMARY | |||
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121596688
Created by
admin on Sat Dec 16 11:29:01 UTC 2023 , Edited by admin on Sat Dec 16 11:29:01 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET -> INHIBITOR |
INHIBITOR
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
Originator: Soricimed Biopharma; Class: Antineoplastic, Peptide; Mechanism of Action: TRPV6 protein inhibitor; Orphan Drug Status: Yes for Ovarian cancer; On Fast track: No; New Molecular Entity: Yes; Highest Development Phases: Phase I for Ovarian cancer, Solid tumours; Most Recent Events: 19 Jul 2016 Final adverse events and efficacy data from a phase I trial in Solid tumours presented at the 107th Annual Meeting of the American Association for Cancer Research (AACR-2016), 08 Mar 2016 SOR C13 receives Orphan Drug status for Ovarian cancer (Late-stage disease) in USA, 23 Feb 2016 Efficacy and adverse events data from a phase I trial in Solid tumours released by Soricimed
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ACTIVE MOIETY |
Official Title: Phase I, Open-label, Dose Escalation Study to Assess Safety and Tolerability of SOR-C13 in Subjects With Advanced Solid Tumors Commonly Known to Express the TRPV6 Ion Channel
Purpose: The purpose of this study is to determine the safety and tolerability of the drug SOR-C13 when given as an intravenous infusion in patients with ovarian cancer or other cancers known to over express the TRPV6 calcium channel.
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