CEFDINIR

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C14H13N5O5S2
Molecular Weight	395.414
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

SMILES

[H][C@]12SCC(C=C)=C(N1C(=O)[C@H]2NC(=O)C(=N/O)\C3=CSC(N)=N3)C(O)=O

InChI

InChIKey=RTXOFQZKPXMALH-GHXIOONMSA-N

InChI=1S/C14H13N5O5S2/c1-2-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24)6-4-26-14(15)16-6/h2,4,8,12,24H,1,3H2,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C14H13N5O5S2
Molecular Weight	395.414
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	1
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical
Record UNII	CI0FAO63WC
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

CEFDINIR

Official Name

English

CEFDINIR [JAN]

Common Name

English

FK-482

Code

English

CEFDINIR [VANDF]

Common Name

English

CEFDINIR [USP-RS]

Common Name

English

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Classification Tree

Code System

Code

Thiazines

NDF-RT

N0000011161

beta-Lactams

NDF-RT

N0000011161

Third-generation cephalosporins

WHO-ATC

J01DD15

Cephalosporins

LIVERTOX

NBK548666

beta-Lactams

NDF-RT

N0000011161

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Code System

Code

Type

Description

RS_ITEM_NUM

1097614

PRIMARY

RXCUI

25037

PRIMARY

RxNorm

ChEMBL

CHEMBL927

PRIMARY

EPA CompTox

DTXSID8046084

PRIMARY

NSC

758926

PRIMARY

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Related Record

Type

Details


					6E7SN358SE

CEFDINIR MONOHYDRATE

SOLVATE->ANHYDROUS


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:

[60 to 70] % (average)


					CI0FAO63WC

CEFDINIR

BASIS OF STRENGTH->SUBSTANCE

Comments:

Calculated on the anhydrous basis

Interaction Type:

ASSAY (HPLC)

Qualification:

USP

Amount:

RELATIONSHIP_AMOUNT [940 to 1030] MICROGRAM/MG (limits)


					6E7SN358SE

CEFDINIR MONOHYDRATE

SALT/SOLVATE -> PARENT

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Related Record

Type

Details


					0W2W754Q55

CEFDINIR LACTONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

RELATIONSHIP_AMOUNT [<0.5] WEIGHT PERCENT (limits)


					0788M5CZWL

7-(4-HYDROXYISOXAZOLE-3-CARBOXAMIDO)-8-OXO-3-VINYL-5-THIA-1-AZABICYCLO(4.2.0)OCT-2-ENE-2-CARBOXYLIC ACID, (6R,7R)-

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

RELATIONSHIP_AMOUNT [<0.5] WEIGHT PERCENT (limits)


					61G2M33IGF

CEFDINIR, (E)-

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

RELATIONSHIP_AMOUNT [<0.7] WEIGHT PERCENT (limits)


					G9Y9M0S93M

3-METHYL CEFDINIR

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

RELATIONSHIP_AMOUNT [<0.7] WEIGHT PERCENT (limits)


					5U6BX3A1F6

(2R)-2-((Z)-2-(2-AMINOTHIAZOL-4-YL)-2-(HYDROXYIMINO)ACETAMIDO)2-((2RS,5RS)-5-METHYL-7-OXO-2,4,5,7-TETRAHYDRO-1H-FURO(3,4-D)(1,3)THIAZIN-2-YL)ACETIC ACID

IMPURITY -> PARENT

Comments:

The limit for the sum of the 4 isomers is 0.7%.

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

RELATIONSHIP_AMOUNT [<0.7] WEIGHT PERCENT (limits)

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Related Record

Type

Details


					CI0FAO63WC

CEFDINIR

ACTIVE MOIETY

Amount:

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Name	Property Type	Amount
Volume of Distribution	PHARMACOKINETIC	[0.06 to 0.64] Liters/Kilogram (average)

Biological Half-life	PHARMACOKINETIC	1.7 hours (average)

ORAL BIOAVAILABILITY	PHARMACOKINETIC	25 % (average)