VERAPAMIL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C27H38N2O4
Molecular Weight	454.6016
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of VERAPAMIL

Structure Search

SMILES

COC1=C(OC)C=C(CCN(C)CCCC(C#N)(C(C)C)C2=CC(OC)=C(OC)C=C2)C=C1

InChI

InChIKey=SGTNSNPWRIOYBX-UHFFFAOYSA-N

InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3

HIDE SMILES / InChI

Molecular Formula	C27H38N2O4
Molecular Weight	454.6016
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:42:15 UTC 2023` Edited by `admin` on `Sat Dec 16 17:42:15 UTC 2023`
Record UNII	CJ0O37KU29
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

VERAPAMIL

Official Name

English

VERAPAMIL SLOW RELEASE

Common Name

English

VERAPAMIL [USAN]

Common Name

English

D-365

Code

English

Verapamil [WHO-DD]

Common Name

English

VERAPAMIL [VANDF]

Common Name

English

CP-165331

Code

English

CP-16,533-1

Code

English

verapamil [INN]

Common Name

English

VERAPAMIL [MI]

Common Name

English

(±)-5-((3,4-DIMETHOXYPHENETHYL)METHYLAMINO)-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE

Systematic Name

English

Classification Tree Code System Code

NDF-RT

N0000175566

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

WHO-VATC

QC09BB10

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

WHO-VATC

QC08DA01

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

WHO-ATC

C08DA51

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

NCI_THESAURUS

C333

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

12.2

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

12.1

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

WHO-VATC

QC08DA51

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

NDF-RT

N0000000069

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

WHO-ATC

C09BB10

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

LIVERTOX

NBK548362

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

WHO-ATC

C08DA01

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

Code System Code Type Description

ECHA (EC/EINECS)

200-145-1

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

CHEBI

9948

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

PUBCHEM

2520

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

IUPHAR

2406

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

DAILYMED

CJ0O37KU29

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

INN

2122

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

NDF-RT

N0000182141

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

Cytochrome P450 3A4 Inhibitors [MoA]

RXCUI

11170

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

RxNorm

SMS_ID

100000079099

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

CAS

52-53-9

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

WIKIPEDIA

VERAPAMIL

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

LACTMED

Verapamil

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

DRUG BANK

DB00661

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

MESH

D014700

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

DRUG CENTRAL

2815

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

NDF-RT

N0000185503

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

P-Glycoprotein Inhibitors [MoA]

NCI_THESAURUS

C928

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

FDA UNII

CJ0O37KU29

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

MERCK INDEX

m11414

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

Merck Index

EPA CompTox

DTXSID9041152

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

EVMPD

SUB00038MIG

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

ChEMBL

CHEMBL6966

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

NDF-RT

N0000190114

Created by admin on Sat Dec 16 17:42:17 UTC 2023 , Edited by admin on Sat Dec 16 17:42:17 UTC 2023

PRIMARY

Cytochrome P450 3A Inhibitors [MoA]

Related Record Type Details


					482M00274D

OCT-2

TRANSPORTER -> INHIBITOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE


					LR0F81F33L

ALDEHYDE OXIDASE

METABOLIC ENZYME -> INHIBITOR

Qualification:

IC50

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> INHIBITOR


					570V991KGQ

SOLUTE CARRIER FAMILY 21 MEMBER 3

TRANSPORTER -> INHIBITOR


					515ZW3T4Z5

OCTN-1

TRANSPORTER -> INHIBITOR


					ONY583280Z

OCT-1

TRANSPORTER -> INHIBITOR


					B46KUN2O9L

MATE-2

TRANSPORTER -> INHIBITOR


					3M13XS26I8

OCTN-2

TRANSPORTER -> SUBSTRATE


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE


					V3888OEY5R

VERAPAMIL HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					6NP3XSMIP3

MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1

TRANSPORTER -> INHIBITOR


					805SU96HKF

CYTOCHROME P450 3A5

METABOLIC ENZYME -> SUBSTRATE


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> INHIBITOR


					Y49M64GZ4Q

MRP-1

TRANSPORTER -> INHIBITOR

Amount:


					515ZW3T4Z5

OCTN-1

TRANSPORTER -> SUBSTRATE

Related Record Type Details


					L49D7PR96D

D-617

METABOLITE -> PARENT

Comments:

22% 0f dose

Interaction Type:

MAJOR

Qualification:

URINE

Amount:


					957Z3K3R56

METABOLITE ACTIVE -> PARENT


					957Z3K3R56

METABOLITE ACTIVE -> PARENT

Interaction Type:

MAJOR

Qualification:

PLASMA


					1HT7NT1N2O

D-620

METABOLITE -> PARENT

Comments:

3-4% of dose

Interaction Type:

MINOR

Qualification:

URINE

Amount:


					2FO843A756

PR-22

METABOLITE -> PARENT

Comments:

3-4% of dose

Interaction Type:

MINOR

Qualification:

URINE


					5Y85567OK6

D-703

METABOLITE -> PARENT

Comments:

7% of dose

Qualification:

URINE


					8XRR2EZX43

D-717

METABOLITE -> PARENT

Comments:

6% of dose

Interaction Type:

MINOR

Qualification:

URINE

Amount:


					957Z3K3R56

METABOLITE ACTIVE -> PARENT

Comments:

6% of dose

Interaction Type:

MINOR

Qualification:

URINE

Related Record Type Details


					CJ0O37KU29

VERAPAMIL

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC				Populations PHARMACOKINETIC

Duration of Action	PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC				Populations PHARMACOKINETIC

Duration of Action	PHARMACOKINETIC