LINIFANIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H18FN5O
Molecular Weight	375.3989
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of LINIFANIB

Structure Search

SMILES

CC1=CC(NC(=O)NC2=CC=C(C=C2)C3=C4C(N)=NNC4=CC=C3)=C(F)C=C1

InChI

InChIKey=MPVGZUGXCQEXTM-UHFFFAOYSA-N

InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)

HIDE SMILES / InChI

Molecular Formula	C21H18FN5O
Molecular Weight	375.3989
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:31:41 UTC 2023` Edited by `admin` on `Sat Dec 16 16:31:41 UTC 2023`
Record UNII	CO93X137CW
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

LINIFANIB

Official Name

English

RG-3635

Code

English

LINIFANIB [USAN]

Common Name

English

UREA, N-(4-(3-AMINO-1H-INDAZOL-4-YL)PHENYL)-N'-(2-FLUORO-5-METHYLPHENYL)-

Systematic Name

English

1-(4-(3-AMINO-1H-INDAZOL-4-YL)PHENYL)-3-(2-FLUORO-5-METHYLPHENYL)UREA

Systematic Name

English

A-741439

Code

English

ABT-869

Code

English

linifanib [INN]

Common Name

English

Linifanib [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1967

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

NCI_THESAURUS

C93259

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

FDA ORPHAN DRUG

240807

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

FDA ORPHAN DRUG

248007

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

Code System Code Type Description

WIKIPEDIA

LINIFANIB

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

PRIMARY

USAN

UU-147

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

PRIMARY

PUBCHEM

11485656

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

PRIMARY

FDA UNII

CO93X137CW

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

PRIMARY

INN

9195

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

PRIMARY

SMS_ID

100000126073

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

PRIMARY

EVMPD

SUB33027

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

PRIMARY

NCI_THESAURUS

C71759

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

PRIMARY

EPA CompTox

DTXSID40229834

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

PRIMARY

CAS

796967-16-3

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

PRIMARY

DRUG BANK

DB06080

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

PRIMARY

ChEMBL

CHEMBL223360

Created by admin on Sat Dec 16 16:31:41 UTC 2023 , Edited by admin on Sat Dec 16 16:31:41 UTC 2023

PRIMARY

Related Record Type Details


					R6DUQ1C64H

MITOGEN-ACTIVATED PROTEIN KINASE 11

TARGET -> INHIBITOR

Related Record Type Details


					45BYZ62R9P

A-849529

METABOLITE ACTIVE -> PARENT

Comments:

Active: CLK2, CSF1R, DYRK1A, FLT3, GSK3A, GSK3B, JAK2, JAK3, KDR, LIMK1, MAP4K2, MAP4K4, PRKACA, PRKX, ROCK1, STK12, STK6, TAO1, CLK4, MET, PLK4, PLK3, ROCK2, SGK, MARK3, STK3, CDC7, CDK2, CSNK1G2, IRAK3, IRAK4, MINK, MKNK2, RPS6KA5, RPS6KB1, CDC2, CSNK2A1, DYRK3, HIPK4, KIAA1811, MAP4K5, TOPK, CSNK1D, SRPK1, ZAK, PRKG1, PRKG2, FLT4, MARK2, PASK, CDK5

Interaction Type:

IN-VITRO


					45BYZ62R9P

A-849529

METABOLITE ACTIVE -> PARENT

Interaction Type:

IN-VIVO

Qualification:

PLASMA

Related Record Type Details


					CO93X137CW

LINIFANIB

ACTIVE MOIETY