NICARDIPINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C26H29N3O6
Molecular Weight	479.525
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of NICARDIPINE

Structure Search

SMILES

COC(=O)C1=C(C)NC(C)=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OCCN(C)CC3=CC=CC=C3

InChI

InChIKey=ZBBHBTPTTSWHBA-UHFFFAOYSA-N

InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3

HIDE SMILES / InChI

Molecular Formula	C26H29N3O6
Molecular Weight	479.525
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:45:51 UTC 2023` Edited by `admin` on `Fri Dec 15 15:45:51 UTC 2023`
Record UNII	CZ5312222S
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

NICARDIPINE

Official Name

English

2-(BENZYLMETHYLAMINO)ETHYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(M-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE

Systematic Name

English

Nicardipine [WHO-DD]

Common Name

English

3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-, 3-METHYL 5-(2-(METHYL(PHENYLMETHYL)AMINO)ETHYL) ESTER

Systematic Name

English

3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-, METHYL 2-(METHYL(PHENYLMETHYL)AMINO)ETHYL ESTER

Common Name

English

NICARDIPINE [VANDF]

Common Name

English

NICARDIPINE [MI]

Common Name

English

(±)-NICARDIPINE

Common Name

English

nicardipine [INN]

Common Name

English

PERPIDINE

Brand Name

English

NICARDIPINE (STN)

Common Name

English

Classification Tree Code System Code

WHO-ATC

C08CA04

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

FDA ORPHAN DRUG

712819

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

NDF-RT

N0000007556

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

NCI_THESAURUS

C333

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

NDF-RT

N0000175421

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

WHO-VATC

QC08CA04

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

NDF-RT

N0000000069

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

LIVERTOX

NBK548755

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

Code System Code Type Description

NCI_THESAURUS

C66879

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

PRIMARY

CAS

55985-32-5

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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SMS_ID

100000091443

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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EPA CompTox

DTXSID6023363

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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MESH

D009529

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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EVMPD

SUB09225MIG

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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NDF-RT

N0000182140

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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Cytochrome P450 2C19 Inhibitors [MoA]

DRUG CENTRAL

1909

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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DRUG BANK

DB00622

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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PUBCHEM

4474

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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IUPHAR

2559

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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NDF-RT

N0000187062

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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Cytochrome P450 2C8 Inhibitors [MoA]

ChEMBL

CHEMBL1484

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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MERCK INDEX

m7850

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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Merck Index

RXCUI

7396

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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RxNorm

INN

4745

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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DAILYMED

CZ5312222S

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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ECHA (EC/EINECS)

259-932-3

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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NDF-RT

N0000182141

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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Cytochrome P450 3A4 Inhibitors [MoA]

LACTMED

Nicardipine

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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FDA UNII

CZ5312222S

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

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NDF-RT

N0000182137

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

PRIMARY

Cytochrome P450 2D6 Inhibitors [MoA]

WIKIPEDIA

NICARDIPINE

Created by admin on Fri Dec 15 15:45:51 UTC 2023 , Edited by admin on Fri Dec 15 15:45:51 UTC 2023

PRIMARY

Related Record Type Details


					5DU0E310OI

2,6-DIMETHYL-5-METHOXYCARBONYL-4-(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3-CARBOXYLIC ACID

SALT/SOLVATE -> PARENT


					KP7NTH0ZW8

NICARDIPINE, (R)-

ENANTIOMER -> RACEMATE


					3JT3BYK2JW

NICARDIPINE, (S)-

ENANTIOMER -> RACEMATE


					9A0ZKH6U7Q

NICARDIPINE HYDROCHLORIDE, (R)-

SALT/SOLVATE -> PARENT


					K5BC5011K3

NICARDIPINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					OIC6NC9Q3P

VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D

TARGET -> INHIBITOR


					8LAW0NT30I

NICARDIPINE HYDROCHLORIDE, (S)-

SALT/SOLVATE -> PARENT

Related Record Type Details


					CZ5312222S

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC				ROUTE OF ADMINISTRATION PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC				ROUTE OF ADMINISTRATION PHARMACOKINETIC