POMALIDOMIDE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H11N3O4
Molecular Weight	273.2441
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of POMALIDOMIDE

Structure Search

SMILES

NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1

InChI

InChIKey=UVSMNLNDYGZFPF-UHFFFAOYSA-N

InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)

HIDE SMILES / InChI

Molecular Formula	C13H11N3O4
Molecular Weight	273.2441
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:29:19 UTC 2023` Edited by `admin` on `Fri Dec 15 15:29:19 UTC 2023`
Record UNII	D2UX06XLB5
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

POMALIDOMIDE

Official Name

English

ACTIMID

Brand Name

English

POMALIDOMIDE [USAN]

Common Name

English

pomalidomide [INN]

Common Name

English

IMID 3

Code

English

Pomalidomide [WHO-DD]

Common Name

English

1H-ISOINDOLE-1,3(2H)-DIONE, 4-AMINO-2-(2,6-DIOXO-3-PIPERIDINYL)-

Systematic Name

English

IMNOVID

Brand Name

English

POMALIDOMIDE [JAN]

Common Name

English

IMID-3

Code

English

CC-4047

Code

English

4-Amino-2-[(3RS)-2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione

Systematic Name

English

POMALIDOMIDE [ORANGE BOOK]

Common Name

English

POMALIDOMIDE [MI]

Common Name

English

POMALIDOMIDE [VANDF]

Common Name

English

3-(3-AMINO)-PHTALAMIDO-GLUTARIMIDE

Common Name

English

POMALIDOMIDE [EMA EPAR]

Common Name

English

POMALYST

Brand Name

English

Classification Tree Code System Code

WHO-VATC

QL04AX06

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

FDA ORPHAN DRUG

308610

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

FDA ORPHAN DRUG

635818

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

EU-Orphan Drug

EU/3/10/759

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

FDA ORPHAN DRUG

161402

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

FDA ORPHAN DRUG

363212

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

NCI_THESAURUS

C129820

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

NCI_THESAURUS

C54677

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

WHO-ATC

L04AX06

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

NDF-RT

N0000184014

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

NCI_THESAURUS

C1742

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

Code System Code Type Description

SMS_ID

100000126117

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

IUPHAR

7348

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

MESH

C467566

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

HSDB

8222

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

FDA UNII

D2UX06XLB5

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

EPA CompTox

DTXSID40893458

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

PUBCHEM

134780

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

DRUG BANK

DB08910

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

LACTMED

Pomalidomide

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

EVMPD

SUB33379

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

MERCK INDEX

m8978

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

Merck Index

RXCUI

1369713

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

RxNorm

USAN

SS-115

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

WIKIPEDIA

POMALIDOMIDE

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

NCI_THESAURUS

C72560

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

INN

8873

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

DRUG CENTRAL

4746

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

DAILYMED

D2UX06XLB5

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

ChEMBL

CHEMBL43452

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

CHEBI

72690

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

JAPANESE REVIEW

POMALYST

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

APPROVED MARCH 2015

CAS

19171-19-8

Created by admin on Fri Dec 15 15:29:19 UTC 2023 , Edited by admin on Fri Dec 15 15:29:19 UTC 2023

PRIMARY

Related Record Type Details


					2EE4M42K6G

POMALIDOMIDE, (S)-

ENANTIOMER -> RACEMATE

Comments:

Pomalidomide is a racemic mixture of the S-enantiomer (CC-5083) and the R-enantiomer (CC-6016) which interconvert in plasma via both enzymatic and non-enzymatic pathways.


					X9549G9WCL

POMALIDOMIDE, (R)-

ENANTIOMER -> RACEMATE

Comments:

Pomalidomide is a racemic mixture of the S-enantiomer (CC-5083) and the R-enantiomer (CC-6016) which interconvert in plasma via both enzymatic and non-enzymatic pathways.


					VK4SQL11C0

CYTOCHROME P450 1A2

METABOLIC ENZYME -> SUBSTRATE


					HR6E2AWX74

CEREBLON

TARGET -> INHIBITOR

Comments:

Dose-dependent interaction with the CRBN-DDB1 complex

Qualification:

IC50

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Related Record Type Details


					2JD83JK9RC

CC-17368

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

URINE

Amount:


					2JD83JK9RC

CC-17368

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

PLASMA

Amount:


					8H195P4LXF

CC-15262

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

URINE

Amount:


					8H195P4LXF

CC-15262

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

URINE

Amount:


					2JD83JK9RC

CC-17368

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

FECAL

Amount:


					1XS9W611WZ

CC-8017

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

FECAL; PLASMA; URINE

Related Record Type Details


					D2UX06XLB5

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Vdss	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC				Elimination PHARMACOKINETIC Elimination PHARMACOKINETIC