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Details

Stereochemistry ACHIRAL
Molecular Formula C12H11NO
Molecular Weight 185.2218
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PIRFENIDONE

SMILES

CC1=CN(C(=O)C=C1)C2=CC=CC=C2

InChI

InChIKey=ISWRGOKTTBVCFA-UHFFFAOYSA-N
InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3

HIDE SMILES / InChI
Molecular Formula C12H11NO
Molecular Weight 185.2218
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:09:12 UTC 2023
Edited
by admin
on Fri Dec 15 17:09:12 UTC 2023
Record UNII
D7NLD2JX7U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PIRFENIDONE
DASH   EMA EPAR   INN   JAN   MART.   MI   USAN   VANDF   WHO-DD  
USAN   INN  
Official Name English
5-Methyl-1-phenyl-2(1H)-pyridone
Systematic Name English
PIRFENIDONE [USAN]
Common Name English
PIRFENIDONE [MART.]
Common Name English
2(1H)-PYRIDINONE, 5-METHYL-1-PHENYL-
Systematic Name English
PIRFENIDONE [EMA EPAR]
Common Name English
PIRFENIDONE [EP MONOGRAPH]
Common Name English
PIRFENIDONE [JAN]
Common Name English
PIRFENIDONE COMPONENT OF ESBRIET
Brand Name English
Pirfenidone [WHO-DD]
Common Name English
PIRFENIDONE [ORANGE BOOK]
Common Name English
pirfenidone [INN]
Common Name English
ESBRIET
Brand Name English
ESBRIET COMPONENT PIRFENIDONE
Brand Name English
PIRFENIDONE [VANDF]
Common Name English
PIRFENIDONE [MI]
Common Name English
AMR-69
Code English
PIRESPA
Brand Name English
NSC-748456
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 727219
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
EU-Orphan Drug EU/3/04/241
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
FDA ORPHAN DRUG 436914
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
EMA ASSESSMENT REPORTS ESBRIET (AUTHORISED: IDIOPATHIC PULMONARY FIBROSIS)
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
NDF-RT N0000191420
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
NCI_THESAURUS C257
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
NCI_THESAURUS C797
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
WHO-ATC L04AX05
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
FDA ORPHAN DRUG 177903
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
WHO-VATC QL04AX05
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
FDA ORPHAN DRUG 411113
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
Code System Code Type Description
NCI_THESAURUS
C2635
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
FDA UNII
D7NLD2JX7U
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
DRUG CENTRAL
4224
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
INN
3825
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
ChEMBL
CHEMBL1256391
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
IUPHAR
7532
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
MERCK INDEX
m8876
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY Merck Index
WIKIPEDIA
PIRFENIDONE
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
PUBCHEM
40632
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
MESH
C093844
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
EPA CompTox
DTXSID4045183
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
HSDB
8340
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
DAILYMED
D7NLD2JX7U
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
CHEBI
32016
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
RXCUI
1592254
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY RxNorm
EVMPD
SUB09907MIG
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
CAS
53179-13-8
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
NDF-RT
N0000007575
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY Pyridones [Chemical/Ingredient]
DRUG BANK
DB04951
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
SMS_ID
100000081645
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
JAPANESE REVIEW
PIRESPA
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY APPROVED OCTOBER 2008
NSC
748456
Created by admin on Fri Dec 15 17:09:12 UTC 2023 , Edited by admin on Fri Dec 15 17:09:12 UTC 2023
PRIMARY
Related Record Type Details
Structure of Deupirfenidone
LABELED -> NON-LABELED
CYTOCHROME P450 1A2
METABOLIC ENZYME -> SUBSTRATE
MAJOR
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
Related Record Type Details
Structure of 5-CARBOXY-PIRFENIDONE
METABOLITE INACTIVE -> PARENT
In vitro profiling studies in hepatocytes and liver microsomes have shown that ESBRIET is primarily metabolized in the liver by CYP1A2 and multiple other CYPs (CYP2C9, 2C19, 2D6, and 2E1).
MAJOR
PLASMA; URINE
Related Record Type Details
Structure of PIRFENIDONE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC MULTIPLE DOSE ADMINISTRATION

Tmax PHARMACOKINETIC ORAL ADMINISTRATION

SINGLE DOSE

Tmax PHARMACOKINETIC FED CONDITION

HIGH-FAT MEAL

Biological Half-life PHARMACOKINETIC
NIH
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