DILTIAZEM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H26N2O4S
Molecular Weight	414.518
Optical Activity	( + )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DILTIAZEM

Structure Search

SMILES

COC1=CC=C(C=C1)[C@@H]2SC3=CC=CC=C3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O

InChI

InChIKey=HSUGRBWQSSZJOP-RTWAWAEBSA-N

InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H26N2O4S
Molecular Weight	414.518
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:27:04 UTC 2023` Edited by `admin` on `Sat Dec 16 16:27:04 UTC 2023`
Record UNII	EE92BBP03H
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DILTIAZEM

Official Name

English

Diltiazem [WHO-DD]

Common Name

English

DILTIAZEM [HSDB]

Common Name

English

DILTIAZEM EXTENDED RELEASE

Common Name

English

DILTIAZEM [VANDF]

Common Name

English

DILTIAZEM [MI]

Common Name

English

SURAZEM

Brand Name

English

1,5-BENZOTHIAZEPIN-4(5H)-ONE, 3-(ACETYLOXY)-5-(U2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-2-(4-METHOXYPHENYL)-, (+)-CIS-

Common Name

English

diltiazem [INN]

Common Name

English

(+)-5-(2-(DIMETHYLAMINO)ETHYL)-CIS-2,3-DIHYDRO-3-HYDROXY-2-(P-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5H)-ONE ACETATE (ESTER)

Common Name

English

DITIAZ [VANDF]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QC08DB01

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

WHO-ATC

C08DB01

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

NDF-RT

N0000000069

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

LIVERTOX

NBK547898

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

WHO-ATC

C05AE03

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

NDF-RT

N0000175566

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

NCI_THESAURUS

C333

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

Code System Code Type Description

FDA UNII

EE92BBP03H

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

CAS

42399-41-7

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

IUPHAR

2298

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

PUBCHEM

39186

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

ECHA (EC/EINECS)

255-796-4

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

DAILYMED

EE92BBP03H

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

ChEMBL

CHEMBL23

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

DRUG BANK

DB00343

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

HSDB

6528

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

INN

3433

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

MERCK INDEX

m4494

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

Merck Index

EVMPD

SUB07148MIG

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

LACTMED

Diltiazem

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

EPA CompTox

DTXSID9022940

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

MESH

D004110

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

DRUG CENTRAL

897

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

CHEBI

101278

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

RXCUI

3443

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

RxNorm

WIKIPEDIA

DILTIAZEM

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

NCI_THESAURUS

C61725

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

SMS_ID

100000082630

Created by admin on Sat Dec 16 16:27:05 UTC 2023 , Edited by admin on Sat Dec 16 16:27:05 UTC 2023

PRIMARY

Related Record Type Details


					OLH94387TE

DILTIAZEM HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE


					Z0TN07HN7X

VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C

TARGET -> INHIBITOR

Comments:

Binding assay

Qualification:

IC50

Amount:


					896626Q8XW

DILTIAZEM MALEATE

SALT/SOLVATE -> PARENT


					14Y6444DRP

DILTIAZEM MALATE

SALT/SOLVATE -> PARENT

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> INHIBITOR


					6NP3XSMIP3

MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1

TRANSPORTER -> INHIBITOR


					B46KUN2O9L

MATE-2

TRANSPORTER -> INHIBITOR


					5W5YGG8Y4A

Voltage-dependent L-type calcium channel subunit alpha-1C (Rat)

TARGET -> INHIBITOR

Interaction Type:

BINDING

Qualification:

IC50

Amount:

Related Record Type Details


					2JQ1D3G54H

DEACETYL-N,O-DIDEMETHYLDILTIAZEM

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

URINE


					JWM585056U

O-DEMETHYLDEACETYLDILTIAZEM

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

URINE


					3QX2LKX8XZ

N-DESMETHYL DESACETYL DILTIAZEM

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

URINE


					IF0841K5LK

N-DEMETHYLDILTIAZEM

METABOLITE -> PARENT

Comments:

In some plasma samples

Interaction Type:

MAJOR

Qualification:

URINE


					849UT193YJ

DEACETYLDILTIAZEM

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

URINE

Related Record Type Details


					EE92BBP03H

DILTIAZEM

ACTIVE MOIETY

Amount: