TENOFOVIR ALAFENAMIDE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H29N6O5P
Molecular Weight	476.4659
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TENOFOVIR ALAFENAMIDE

Structure Search

SMILES

CC(C)OC(=O)[C@H](C)N[P@](=O)(CO[C@H](C)CN1C=NC2=C(N)N=CN=C12)OC3=CC=CC=C3

InChI

InChIKey=LDEKQSIMHVQZJK-CAQYMETFSA-N

InChI=1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C21H29N6O5P
Molecular Weight	476.4659
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 06:04:36 UTC 2023` Edited by `admin` on `Sat Dec 16 06:04:36 UTC 2023`
Record UNII	EL9943AG5J
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TENOFOVIR ALAFENAMIDE

Official Name

English

tenofovir alafenamide [INN]

Common Name

English

TENOFOVIR ALAFENAMIDE [MI]

Common Name

English

GS-734003

Code

English

Tenofovir alafenamide [WHO-DD]

Common Name

English

L-ALANINE, N-((S)-(((1R)-2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY)METHYL)PHENOXYPHOSPHINYL)-, 1-METHYLETHYL ESTER

Common Name

English

GS-7340

Code

English

1-METHYLETHYL N-((S)-(((1R)-2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY)METHYL)PHENOXYPHOSPHINYL)-L-ALANINATE

Systematic Name

English

TENOFOVIR ALAFENAMIDE [USAN]

Common Name

English

Classification Tree Code System Code

WHO-ATC

J05AF13

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

EMA ASSESSMENT REPORTS

GENVOYA (AUTHORIZED: HIV INFECTIONS)

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

WHO-ATC

J05AR19

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

EMA ASSESSMENT REPORTS

DESCOVY (AUTHORIZED: HIV INFECTIONS )

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

WHO-ATC

J05AR22

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

FDA ORPHAN DRUG

569716

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

WHO-ATC

J05AR18

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

NCI_THESAURUS

C97452

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

NCI_THESAURUS

C281

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

WHO-ATC

J05AR20

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

Code System Code Type Description

DRUG CENTRAL

4944

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

WIKIPEDIA

Tenofovir alafenamide

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

INN

9980

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

CAS

379270-37-8

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

ChEMBL

CHEMBL2107825

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

FDA UNII

EL9943AG5J

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

EVMPD

SUB121761

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

CHEBI

90926

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

SMS_ID

100000144893

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

DRUG BANK

DB09299

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

RXCUI

1721603

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

RxNorm

DAILYMED

EL9943AG5J

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

NCI_THESAURUS

C148276

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

USAN

ZZ-65

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

MERCK INDEX

m12126

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

EPA CompTox

DTXSID50958941

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

PUBCHEM

9574768

Created by admin on Sat Dec 16 06:04:36 UTC 2023 , Edited by admin on Sat Dec 16 06:04:36 UTC 2023

PRIMARY

Related Record Type Details


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE

Amount:


					QZP2PG26WP

TENOFOVIR ALAFENAMIDE ENANTIOMER

ENANTIOMER -> ENANTIOMER

Amount:


					HPN66MJEK8

LIVER CARBOXYLESTERASE 1

METABOLIC ENZYME -> SUBSTRATE

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					76UB6O122H

ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2

TRANSPORTER -> SUBSTRATE

Amount:


					FWF6Q91TZO

TENOFOVIR ALAFENAMIDE FUMARATE

SALT/SOLVATE -> PARENT

Amount:


					5HP2CJM5GF

TENOFOVIR ALAFENAMIDE SEBACATE

SALT/SOLVATE -> PARENT

Amount:


					AIN96D6SGL

OATP1B1

TRANSPORTER -> SUBSTRATE

Amount:


					66DDF797LP

OATP-8

TRANSPORTER -> SUBSTRATE

Amount:


					H2S5S51WW6

TENOFOVIR ALAFENAMIDE MONOFUMARATE

SALT/SOLVATE -> PARENT

Amount:


					SU59CZ8IUV

LYSOSOMAL PROTECTIVE PROTEIN

METABOLIC ENZYME -> SUBSTRATE

Amount:

Related Record Type Details


					W4HFE001U5

TENOFOVIR ANHYDROUS

METABOLITE ACTIVE -> PRODRUG

Amount:

Related Record Type Details


					W4HFE001U5

TENOFOVIR ANHYDROUS

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC