Ezetimibe

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H21F2NO3
Molecular Weight	409.4252
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of Ezetimibe

Structure Search

SMILES

O[C@@H](CC[C@@H]1[C@H](N(C1=O)C2=CC=C(F)C=C2)C3=CC=C(O)C=C3)C4=CC=C(F)C=C4

InChI

InChIKey=OLNTVTPDXPETLC-XPWALMASSA-N

InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C24H21F2NO3
Molecular Weight	409.4252
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:57:43 UTC 2023` Edited by `admin` on `Fri Dec 15 15:57:43 UTC 2023`
Record UNII	EOR26LQQ24
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Ezetimibe

Official Name

English

EZETIMIBE [USP MONOGRAPH]

Common Name

English

EZETIMIBE [JAN]

Common Name

English

EZETIMIBE [USAN]

Common Name

English

EZETIMIBE [USP-RS]

Common Name

English

EZETIMIBE [VANDF]

Common Name

English

SCH-58235

Code

English

SCH58235

Code

English

ROSZET COMPONENT EZETIMIBE

Brand Name

English

EZETIMIBE [MI]

Common Name

English

EZETIMIBE COMPONENT OF VYTORIN

Brand Name

English

NEXLIZET COMPONENT EZETIMIBE

Brand Name

English

NSC-758923

Code

English

EZETIMIBE [ORANGE BOOK]

Common Name

English

EZETIMIBE COMPONENT OF NEXLIZET

Brand Name

English

EZETIMIBE [MART.]

Common Name

English

VYTORIN COMPONENT EZETIMIBE

Brand Name

English

ZETIA

Brand Name

English

(3R,4S)-1-(P-FLUOROPHENYL)-3-((3S)-3-(P-FLUOROPHENYL)-3-HYDROXYPROPYL)-4-(P-HYDROXYPHENYL)-2-AZETIDINONE

Systematic Name

English

EZETROL

Brand Name

English

MK0653

Code

English

EZETIMIBE COMPONENT OF ROSZET

Brand Name

English

EZETIMIBE [HSDB]

Common Name

English

Ezetimibe [WHO-DD]

Common Name

English

2-AZETIDINONE, 1-(4-FLUOROPHENYL)-3-(3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL)-4-(4-HYDROXYPHENYL)-, (3R-(3.ALPHA.(S*),4.BETA.))-

Systematic Name

English

K-924 component Ezetimibe

Common Name

English

ezetimibe [INN]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000008553

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

WHO-ATC

C10BA05

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

WHO-VATC

QC10AX09

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

WHO-VATC

QC10BA06

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

WHO-ATC

C10BA06

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

WHO-ATC

C10BA02

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

WHO-ATC

C10AX09

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

WHO-VATC

QC10BA05

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

NCI_THESAURUS

C29703

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

WHO-VATC

QC10BA02

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

LIVERTOX

NBK548095

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

NDF-RT

N0000175911

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

Code System Code Type Description

FDA UNII

EOR26LQQ24

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

INN

8010

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

DAILYMED

EOR26LQQ24

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

NCI_THESAURUS

C47529

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

RS_ITEM_NUM

1269028

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

JAPANESE REVIEW

ZETIA

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

APPROVE APRIL 2007

PUBCHEM

150311

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

MERCK INDEX

m5228

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

Merck Index

EVMPD

SUB16430MIG

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

CAS

163222-33-1

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

ChEMBL

CHEMBL1138

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

SMS_ID

100000091598

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

HSDB

7737

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

DRUG BANK

DB00973

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

LACTMED

Ezetimibe

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

DRUG CENTRAL

1125

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

EPA CompTox

DTXSID1044223

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

NDF-RT

N0000008553

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

Decreased Cholesterol Absorption [PE]

RXCUI

341248

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

RxNorm

USAN

LL-18

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

WIKIPEDIA

EZETIMIBE

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

IUPHAR

6816

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

NSC

758923

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

CHEBI

49040

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

MESH

C108606

Created by admin on Fri Dec 15 15:57:43 UTC 2023 , Edited by admin on Fri Dec 15 15:57:43 UTC 2023

PRIMARY

Related Record Type Details


					EOR26LQQ24

Ezetimibe

EXCRETED UNCHANGED

Interaction Type:

MAJOR

Qualification:

FECAL

Amount:


					97C5T2UQ7J

TARGET->INHIBITOR OF ABSORPTION

Amount:


					IHQ709299P

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A3

METABOLIC ENZYME -> SUBSTRATE


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					0RFO7VC96N

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1

METABOLIC ENZYME -> SUBSTRATE


					97C5T2UQ7J

TARGET->INHIBITOR OF ABSORPTION

Amount:

Related Record Type Details


					E575Y24YTQ

(1S)-1-(4-FLUOROPHENYL)-3-((2S,3R)-1-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-4-OXO-3-AZETIDINYL)PROPYL .BETA.-D-GLUCOPYRANOSIDURONIC ACID

METABOLITE -> PARENT

Interaction Type:

TRACE


					9D3ASE5ZPY

EZETIMIBE KETONE

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

FECAL

Amount:


					QXG49H7QMG

EZETIMIBE KETONE GLUCURONIDE

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

URINE

Amount:

Related Record Type Details


					B77NRJ8FJS

1-(3-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone, (3R,4S)-

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					4LK8SY3P76

(3S,4S)-1-(4-Fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					T6T337VHP6

2H-Pyran-3-carboxamide, N,6-bis(4-fluorophenyl)tetrahydro-2-(4-hydroxyphenyl)-, (2R,3R,6S)-

IMPURITY -> PARENT

Comments:

From ANDA on applications

Amount:


					T0T1Y8DU99

(3R,4R)-1-(4-FLUOROPHENYL)-3-((R)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL)-4-(4-HYDROXYPHENYL)AZETIDIN-2-ONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					9VH23QW5GX

(3S,4R)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-[(trimethylsilyl)oxy]propyl]-4-[4-[(trimethylsilyl)oxy]phenyl]-2-azetidinone

IMPURITY -> PARENT

Amount:


					7XS0TM202F

(3S,4R)-1-(4-FLUOROPHENYL)-3-((S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL)-4-(4-HYDROXYPHENYL)AZETIDIN-2-ONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					9D3ASE5ZPY

EZETIMIBE KETONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					JMX6V14RUT

(3R,4S)-3-((3S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL)-4-(4-HYDROXYPHENYL)-1-PHENYL-2-AZETIDINONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					FST3D70Q0D

(3S,4R)-1-(4-FLUOROPHENYL)-3-((R)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL)-4-(4-HYDROXYPHENYL)AZETIDIN-2-ONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

Related Record Type Details


					EOR26LQQ24

Ezetimibe

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC