BELINOSTAT

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H14N2O4S
Molecular Weight	318.348
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of BELINOSTAT

Structure Search

SMILES

ONC(=O)\C=C\C1=CC(=CC=C1)S(=O)(=O)NC2=CC=CC=C2

InChI

InChIKey=NCNRHFGMJRPRSK-MDZDMXLPSA-N

InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+

HIDE SMILES / InChI

Molecular Formula	C15H14N2O4S
Molecular Weight	318.348
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:35:41 UTC 2023` Edited by `admin` on `Fri Dec 15 15:35:41 UTC 2023`
Record UNII	F4H96P17NZ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BELINOSTAT

Official Name

English

BELINOSTAT [VANDF]

Common Name

English

N-HYDROXY-3-(3-((PHENYLAMINO)SULFONYL)PHENYL)-2-PROPENAMIDE

Systematic Name

English

NSC-726630

Code

English

2-PROPENAMIDE, N-HYDROXY-3-(3-((PHENYLAMINO)SULFONYL)PHENYL)-, (2E)-

Systematic Name

English

PX-105684

Code

English

BELEODAQ

Brand Name

English

BELINOSTAT [USAN]

Common Name

English

BELINOSTAT [ORANGE BOOK]

Common Name

English

2-PROPENAMIDE, N-HYDROXY-3-(3-((PHENYLAMINO)SULFONYL)PHENYL)-

Systematic Name

English

PXD-101

Code

English

BELINOSTAT [MI]

Common Name

English

(2E)-N-HYDROXY-3-(3-(PHENYLSULFAMOYL)PHENYL)PROP-2-ENAMIDE

Systematic Name

English

Belinostat [WHO-DD]

Common Name

English

PXD101

Code

English

belinostat [INN]

Common Name

English

N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide

Systematic Name

English

Classification Tree Code System Code

NDF-RT

N0000175588

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

WHO-ATC

L01XX49

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

FDA ORPHAN DRUG

289309

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

NCI_THESAURUS

C1946

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

EU-Orphan Drug

EU/3/13/1151

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

Code System Code Type Description

ChEMBL

CHEMBL408513

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

NCI_THESAURUS

C48812

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

EPA CompTox

DTXSID60194378

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

MERCK INDEX

m2295

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

Merck Index

IUPHAR

7496

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

NSC

726630

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

USAN

SS-19

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

RXCUI

1543543

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

RxNorm

CHEBI

61076

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

INN

8823

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

FDA UNII

F4H96P17NZ

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

DRUG CENTRAL

4876

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

DAILYMED

F4H96P17NZ

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

SMS_ID

100000144569

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

CAS

866323-14-0

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

PUBCHEM

6918638

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

WIKIPEDIA

BELINOSTAT

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

CAS

414864-00-9

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

NON-SPECIFIC STEREOCHEMISTRY

EVMPD

SUB121262

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

DRUG BANK

DB05015

Created by admin on Fri Dec 15 15:35:41 UTC 2023 , Edited by admin on Fri Dec 15 15:35:41 UTC 2023

PRIMARY

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METABOLITE INACTIVE -> PARENT

Comments:

MEDIATOR: UGT1A1

Interaction Type:

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METABOLITE -> PARENT

Comments:

The enzymes responsible for the formation of 3-(anilinosulfonyl)-benzenecarboxylic acid, (3-ASBA) are not known.


					40EYG848GW

BELINOSTAT AMIDE

METABOLITE -> PARENT

Qualification:

PLASMA; URINE

Amount:


					40EYG848GW

BELINOSTAT AMIDE

METABOLITE -> PARENT

Comments:

Belinostat also undergoes hepatic metabolism by CYP2A6, CYP2C9, and CYP3A4 enzymes to form belinostat amide and belinostat acid.

Amount:


					D342E3PX5U

BELINOSTAT ACID

METABOLITE -> PARENT

Amount:


					D342E3PX5U

BELINOSTAT ACID

METABOLITE -> PARENT

Comments:

Belinostat also undergoes hepatic metabolism by CYP2A6, CYP2C9, and CYP3A4 enzymes to form belinostat amide and belinostat acid.

Interaction Type:

MAJOR

Qualification:

PLASMA; URINE

Amount:


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METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

PLASMA; URINE


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METABOLITE INACTIVE -> PARENT

Related Record Type Details


					F4H96P17NZ

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC