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Details

Stereochemistry ACHIRAL
Molecular Formula C22H18N6
Molecular Weight 366.4185
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of RILPIVIRINE

SMILES

CC1=CC(\C=C\C#N)=CC(C)=C1NC2=NC(NC3=CC=C(C=C3)C#N)=NC=C2

InChI

InChIKey=YIBOMRUWOWDFLG-ONEGZZNKSA-N
InChI=1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+

HIDE SMILES / InChI
Molecular Formula C22H18N6
Molecular Weight 366.4185
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:22:05 UTC 2023
Edited
by admin
on Fri Dec 15 16:22:05 UTC 2023
Record UNII
FI96A8X663
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RILPIVIRINE
DASH   INN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
Rilpivirine [WHO-DD]
Common Name English
R278474
Code English
RILPIVIRINE COMPONENT OF CABENUVA
Brand Name English
rilpivirine [INN]
Common Name English
R-278474
Code English
TMC-278
Code English
4-{[4-({4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile
Systematic Name English
RILPIVIRINE [USAN]
Common Name English
RILPIVIRINE [MI]
Common Name English
EDURANT
Brand Name English
BENZONITRILE, 4-((4-((4-((1E)-2-CYANOETHENYL)-2,6-DIMETHYLPHENYL)AMINO)-2- PYRIMIDINYL)AMINO)-
Systematic Name English
CABENUVA COMPONENT RILPIVIRINE
Brand Name English
RILPIVIRINE [VANDF]
Common Name English
RILPIVIRINE [MART.]
Common Name English
RILPIVIRINE [JAN]
Common Name English
TMC278
Code English
RILPIVIRINE [ORANGE BOOK]
Common Name English
Classification Tree Code System Code
WHO-ATC J05AG05
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
WHO-ATC J05AR08
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
FDA ORPHAN DRUG 858321
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
NDF-RT N0000175463
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
NCI_THESAURUS C97453
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
WHO-VATC QJ05AG05
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
WHO-ATC J05AR19
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
LIVERTOX NBK548514
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
WHO-ATC J05AR21
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
WHO-VATC QJ05AR08
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
Code System Code Type Description
CHEBI
68602
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
NCI_THESAURUS
C76929
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
INN
8469
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
PUBCHEM
6451164
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
CAS
500287-72-9
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
DRUG BANK
DB08864
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
HSDB
8153
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
MERCK INDEX
m9619
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY Merck Index
USAN
WW-86
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
EVMPD
SUB31456
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
SMS_ID
100000124141
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
RXCUI
1102270
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY RxNorm
EPA CompTox
DTXSID10198189
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
DAILYMED
FI96A8X663
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
WIKIPEDIA
RILPIVIRINE
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
LACTMED
Rilpivirine
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
CHEBI
68606
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
ChEMBL
CHEMBL175691
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
DRUG CENTRAL
4174
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
FDA UNII
FI96A8X663
Created by admin on Fri Dec 15 16:22:05 UTC 2023 , Edited by admin on Fri Dec 15 16:22:05 UTC 2023
PRIMARY
Related Record Type Details
CYTOCHROME P450 2C19
METABOLIC ENZYME -> SUBSTRATE
Structure of RILPIVIRINE
EXCRETED UNCHANGED
FECAL
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 POLYMERASE
TARGET -> INHIBITOR
Structure of RILPIVIRINE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
TARGET ORGANISM->INHIBITOR
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
MAJOR
Related Record Type Details
Structure of 2-(2-(4-CYANOANILINO)-9-METHYL-5,10-DIHYDROPYRIMIDO(4,5-B)QUINOLIN-7-YL)ACETIC ACID
METABOLITE -> PARENT
Structure of 4-((7-((E)-2-CYANOVINYL)-9-METHYL-5,10-DIHYDROPYRIMIDO(4,5-B)QUINOLIN-2-YL)AMINO)BENZONITRILE
METABOLITE -> PARENT
Structure of 2-(4-((2-(4-CYANOANILINO)PYRIMIDIN-4-YL)AMINO)-3,5-DIMETHYL-PHENYL)ACETIC ACID
METABOLITE -> PARENT
Structure of (2S,3S,4S,5R)-6-(2-(4-CYANOANILINO)-4-(4-((E)-2-CYANOVINYL)-2,6-DIMETHYL-ANILINO)PYRIMIDIN-1-YL)OXY-3,4,5-TRIHYDROXY-TETRAHYDROPYRAN-2-CARBOXYLIC ACID
METABOLITE -> PARENT
Structure of 4-((4-(4-((E)-2-CYANOVINYL)-2-(HYDROXYMETHYL)-6-METHYL-ANILINO)PYRIMIDIN-2-YL)AMINO)BENZONITRILE
METABOLITE -> PARENT
Structure of (2R)-2-ACETAMIDO-3-(2-CYANO-1-(4-((2-(4-CYANOANILINO)PYRIMIDIN-4-YL)AMINO)-3,5-DIMETHYL-PHENYL)ETHYL)SULFANYL-PROPANOIC ACID
METABOLITE -> PARENT
Structure of 5-HYDROXY-RILPIVIRINE
METABOLITE -> PARENT
Related Record Type Details
Structure of RILPIVIRINE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Blood-to-plasma ratio PHARMACOKINETIC
Structure of RILPIVIRINE
Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC
Tmax PHARMACOKINETIC oral administration

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