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Details

Stereochemistry ACHIRAL
Molecular Formula C12H9F3N2O2
Molecular Weight 270.2073
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LEFLUNOMIDE

SMILES

CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F

InChI

InChIKey=VHOGYURTWQBHIL-UHFFFAOYSA-N
InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)

HIDE SMILES / InChI
Molecular Formula C12H9F3N2O2
Molecular Weight 270.2073
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:32:43 UTC 2023
Edited
by admin
on Fri Dec 15 15:32:43 UTC 2023
Record UNII
G162GK9U4W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LEFLUNOMIDE
EMA EPAR   EP   HSDB   INN   JAN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
USAN   INN  
Official Name English
leflunomide [INN]
Common Name English
LEFLUNOMIDE [USP-RS]
Common Name English
LEFLUNOMIDE WINTHROP
Brand Name English
LEFLUNOMIDE RATIOPHARM
Brand Name English
LEFLUNOMIDE [USAN]
Common Name English
LEFLUNOMIDE [USP MONOGRAPH]
Common Name English
ARAVA
Brand Name English
HWA-486
Code English
SULOL
Code English
Leflunomide [WHO-DD]
Common Name English
LEFLUNOMIDE [JAN]
Common Name English
LEFLUNOMIDE TEVA
Brand Name English
NSC-759864
Code English
LEFLUNOMIDE [EP IMPURITY]
Common Name English
SU101
Code English
LEFLUNOMIDE [MART.]
Common Name English
NSC-677411
Code English
LEFLUNOMIDE [EMA EPAR]
Common Name English
LEFLUNOMIDE [HSDB]
Common Name English
REPSO
Brand Name English
LEFLUNOMIDE MEDAC
Brand Name English
LEFLUNOMIDE [ORANGE BOOK]
Common Name English
L04AA13
Code English
N-(4-(TRIFLUOROMETHYL)PHENYL) 5 METHYLISOXAZOLE-4-CARBOXAMIDE
Systematic Name English
LEFLUNOMIDE [MI]
Common Name English
LEFLUNOMIDE [EP MONOGRAPH]
Common Name English
SU-101
Code English
4-ISOXAZOLECARBOXAMIDE, 5-METHYL-N-(4-(TRIFLUOROMETHYL)PHENYL)-
Systematic Name English
LEFLUNOMIDE [VANDF]
Common Name English
Classification Tree Code System Code
EMA ASSESSMENT REPORTS LEFLUNOMIDE RATIOPHARM (AUTHORIZED: ARTHITIS, RHEUMATOID)
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
FDA ORPHAN DRUG 89895
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
EMA ASSESSMENT REPORTS LEFLUNOMIDE WINTHROP (AUTHORIZED: ARTHRITIS, PSORIATIC)
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
NCI_THESAURUS C1971
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
EMA ASSESSMENT REPORTS ARAVA (AUTHORIZED: ARTHRITIS, RHEUMATOID)
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
LIVERTOX NBK548725
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
NCI_THESAURUS C1557
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
NCI_THESAURUS C2169
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
EMA ASSESSMENT REPORTS ARAVA (AUTHORIZED: ARTHRITIS, PSORIATIC)
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
EMA ASSESSMENT REPORTS LEFLUNOMIDE TEVA (AUTHORIZED: ARTHRITIS, RHEUMATOID)
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
WHO-ATC L04AA13
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
WHO-VATC QL04AA13
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
FDA ORPHAN DRUG 100296
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
EMA ASSESSMENT REPORTS REPSO (AUTHORIZED: ARTHRITIS, PSORIATIC)
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
EMA ASSESSMENT REPORTS REPSO (AUTHORIZED: ARTHRITIS, RHEUMATOID)
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
EMA ASSESSMENT REPORTS LEFLUNOMIDE WINTHROP (AUTHORIZED: ARTHRITIS, RHEUMATOID)
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
EMA ASSESSMENT REPORTS LEFLUNOMIDE MEDAC (AUTHORIZED: ARTHRITIS, RHEUMATOID)
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
FDA ORPHAN DRUG 95095
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
NDF-RT N0000175713
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
Code System Code Type Description
CAS
75706-12-6
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
INN
5079
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
SMS_ID
100000085463
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
RXCUI
27169
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY RxNorm
NSC
759864
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
DRUG BANK
DB01097
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
MESH
C045463
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
HSDB
7289
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
EPA CompTox
DTXSID9023201
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
USAN
KK-119
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
DRUG CENTRAL
1552
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
NCI_THESAURUS
C1128
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
DAILYMED
G162GK9U4W
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
LACTMED
Leflunomide
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
MERCK INDEX
m6756
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY Merck Index
FDA UNII
G162GK9U4W
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
RS_ITEM_NUM
1356960
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
CHEBI
6402
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
IUPHAR
6825
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
ChEMBL
CHEMBL960
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
EVMPD
SUB08424MIG
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
WIKIPEDIA
LEFLUNOMIDE
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
PUBCHEM
3899
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
NSC
677411
Created by admin on Fri Dec 15 15:32:43 UTC 2023 , Edited by admin on Fri Dec 15 15:32:43 UTC 2023
PRIMARY
Related Record Type Details
Structure of LEFLUNOMIDE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
Structure of LEFLUNOMIDE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
EP
Related Record Type Details
Structure of 4-(TRIFLUOROMETHYL)ANILINE
METABOLITE -> PARENT
Leflunomide is metabolized to one primary (M1) and many minor metabolites. Of these minor metabolites, only 4-trifluoromethylaniline (TFMA) is quantifiable
MINOR
PLASMA
Structure of MANITIMUS
METABOLITE ACTIVE -> PARENT
Structure of TERIFLUNOMIDE
METABOLITE ACTIVE -> PRODRUG
Related Record Type Details
Structure of 2-CYANO-N-(4-(TRIFLUOROMETHYL)PHENYL)ACETAMIDE
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of 5-METHYLISOXAZOLE-4-CARBOXYLIC ACID
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of 5-METHYL-N-(2-(TRIFLUOROMETHYL)PHENYL)ISOXAZOLE-4-CARBOXAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 5-METHYL-N-(3-(TRIFLUOROMETHYL)PHENYL)ISOXAZOLE-4-CARBOXAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of TERIFLUNOMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 4-(TRIFLUOROMETHYL)ANILINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 5-METHYL-N-(3-(TRIFLUOROMETHYL)PHENYL)ISOXAZOLE-4-CARBOXAMIDE
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of 5-METHYL-N-(2-(TRIFLUOROMETHYL)PHENYL)ISOXAZOLE-4-CARBOXAMIDE
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of 5-METHYL-N-(4-METHYLPHENYL)ISOXAZOLE-4-CARBOXAMIDE
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of 4-(TRIFLUOROMETHYL)ANILINE
IMPURITY -> PARENT
UNSPECIFIED
USP
Structure of 5-METHYLISOXAZOLE-4-CARBOXYLIC ACID
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 2-CYANO-N-(4-(TRIFLUOROMETHYL)PHENYL)ACETAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of TERIFLUNOMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 3-METHYL-N-(4-(TRIFLUOROMETHYL)PHENYL)ISOXAZOLE-4-CARBOXAMIDE
IMPURITY -> PARENT
UNSPECIFIED
EP
Related Record Type Details
Structure of TERIFLUNOMIDE
ACTIVE MOIETY
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