AZTREONAM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C13H17N5O8S2
Molecular Weight	435.433
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of AZTREONAM

Structure Search

SMILES

C[C@H]1[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\C2=CSC(N)=N2)C(=O)N1S(O)(=O)=O

InChI

InChIKey=WZPBZJONDBGPKJ-VEHQQRBSSA-N

InChI=1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C13H17N5O8S2
Molecular Weight	435.433
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	1
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:46:15 UTC 2023` Edited by `admin` on `Fri Dec 15 15:46:15 UTC 2023`
Record UNII	G2B4VE5GH8
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AZTREONAM

Official Name

English

AZACTAM

Brand Name

English

AZTREONAM [JAN]

Common Name

English

AZTREON

Brand Name

English

AZTREONAM [USP-RS]

Common Name

English

SQ 26776

Code

English

AZTREONAM [MI]

Common Name

English

AZONAM

Brand Name

English

AZTREONAM [USP MONOGRAPH]

Common Name

English

AZTREONAM [VANDF]

Common Name

English

AZTREONAM [USAN]

Common Name

English

NEBACTAM

Brand Name

English

Aztreonam [WHO-DD]

Common Name

English

NSC-646279

Code

English

PRIMBACTAM

Brand Name

English

(Z)-2-[[[(2-Amino-4-thiazolyl)[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]carbamoyl]methylene]amino]oxy]-2-methylpropionic acid

Systematic Name

English

PROPANOIC ACID, 2-(((1-(2-AMINO-4-THIAZOLYL)-2-((2-METHYL-4-OXO-1-SULFO-3-AZETIDINYL)AMINO)-2-OXOETHYLIDENE)AMINO)OXY)-2-METHYL-, (2S-(2.ALPHA.,3.BETA.(Z)))-

Common Name

English

AZTREONAM [MART.]

Common Name

English

aztreonam [INN]

Common Name

English

NSC-758913

Code

English

SQ-26776

Code

English

AZTREONAM [ORANGE BOOK]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000011311

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

NDF-RT

N0000011311

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

LIVERTOX

NBK548462

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

FDA ORPHAN DRUG

155002

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

NDF-RT

N0000011311

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

NDF-RT

N0000011311

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

NCI_THESAURUS

C260

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

WHO-VATC

QJ01DF01

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

NDF-RT

N0000011311

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

WHO-ATC

J01DF01

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

NDF-RT

N0000011311

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

NDF-RT

N0000011311

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

NDF-RT

N0000011311

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

FDA ORPHAN DRUG

266208

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

NDF-RT

N0000175493

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

NDF-RT

N0000011311

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

Code System Code Type Description

ECHA (EC/EINECS)

278-839-9

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

PUBCHEM

5742832

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

MERCK INDEX

m2188

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

Merck Index

EVMPD

SUB05664MIG

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

NCI_THESAURUS

C28845

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

CHEBI

161680

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

ChEMBL

CHEMBL3545256

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

FDA UNII

G2B4VE5GH8

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

LACTMED

Aztreonam

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

CAS

78110-38-0

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

NSC

646279

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

DAILYMED

G2B4VE5GH8

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

EPA CompTox

DTXSID0022640

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

DRUG BANK

DB00355

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

SMS_ID

100000091595

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

DRUG CENTRAL

279

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

MESH

D001398

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

RXCUI

1272

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

RxNorm

WIKIPEDIA

AZTREONAM

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

INN

5159

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

NSC

758913

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

RS_ITEM_NUM

1046205

Created by admin on Fri Dec 15 15:46:15 UTC 2023 , Edited by admin on Fri Dec 15 15:46:15 UTC 2023

PRIMARY

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					Y793W5V55N

PSEUDOMONAS AERUGINOSA

TARGET ORGANISM->INHIBITOR

Comments:

Indicated for the suppressive therapy of chronic pulmonary infections due to Pseudomonas aeruginosa in patients with cystic fibrosis (CF) aged 6 years and older.

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					XNM7LT65NP

AZTREONAM LYSINE

SALT/SOLVATE -> PARENT

Amount:


					G2B4VE5GH8

AZTREONAM

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

USP

Amount:

Related Record Type Details


					7O397SYG7R

SQ-26992

METABOLITE INACTIVE -> PARENT

Amount:

Related Record Type Details


					3B8661C1EQ

DESULFATED AZTREONAM

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					7O397SYG7R

SQ-26992

IMPURITY -> PARENT

Comments:

Open-ring aztreonam and open-ring desulfated aztreonam coelute. The limit is for the sum of these two impurities (1.0 WEUGHT PERCENT)

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					5Q55M3D9UA

SQ-28429

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					U67H95ZRD5

AZTREONAM ETHYL ESTER

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					D2GEP437EQ

OPEN-RING DESULFATED AZTREONAM

IMPURITY -> PARENT

Comments:

Open-ring aztreonam and open-ring desulfated aztreonam coelute. The limit is for the sum of these two impurities (1.0 WEIGHT PERCENT)

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

Related Record Type Details


					G2B4VE5GH8

AZTREONAM

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Cmax	PHARMACOKINETIC				Amount Administered PHARMACOKINETIC Time of measurement PHARMACOKINETIC Dosage form PHARMACOKINETIC Method of administration PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC