TICAGRELOR

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H28F2N6O4S
Molecular Weight	522.568
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TICAGRELOR

Structure Search

SMILES

CCCSC1=NC2=C(N=NN2[C@@H]3C[C@H](OCCO)[C@@H](O)[C@H]3O)C(N[C@@H]4C[C@H]4C5=CC=C(F)C(F)=C5)=N1

InChI

InChIKey=OEKWJQXRCDYSHL-FNOIDJSQSA-N

InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C23H28F2N6O4S
Molecular Weight	522.568
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:04:36 UTC 2023` Edited by `admin` on `Fri Dec 15 16:04:36 UTC 2023`
Record UNII	GLH0314RVC
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TICAGRELOR

Official Name

English

BRILINTA

Brand Name

English

1,2-CYCLOPENTANEDIOL, 3-(7-(((1R,2S)-2-(3,4-DIFLUOROPHENYL)CYCLOPROPYL)AMINO)-5-(PROPYLTHIO)-3H-1,2,3-TRIAZOLO(4,5-D)PYRIMIDIN-3-YL)-5-(2-HYDROXYETHOXY)-, (1S,2S,3R,5S)-

Systematic Name

English

AZD-6140

Code

English

TICAGRELOR [MI]

Common Name

English

(1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

Systematic Name

English

POSSIA

Brand Name

English

TICAGRELOR [EMA EPAR]

Common Name

English

Ticagrelor [WHO-DD]

Common Name

English

TICAGRELOR [EP MONOGRAPH]

Common Name

English

TICAGRELOR [USAN]

Common Name

English

TICAGRELOR [ORANGE BOOK]

Common Name

English

ticagrelor [INN]

Common Name

English

TICAGRELOR [USP-RS]

Common Name

English

TICAGRELOR [JAN]

Common Name

English

TICAGRELOR [MART.]

Common Name

English

AZD6140

Code

English

BRILIQUE

Brand Name

English

AR-C126532XX

Code

English

TICAGRELOR [VANDF]

Common Name

English

Classification Tree Code System Code

EMA ASSESSMENT REPORTS

POSSIA (WITHDRAWN: PERIPHERAL VASCULAR DISEASES)

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

EMA ASSESSMENT REPORTS

BRILIQUE (AUTHORIZED: PERIPHERAL VASCULAR DISEASES)

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

WHO-ATC

B01AC24

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

EMA ASSESSMENT REPORTS

POSSIA (WITHDRAWN: ACUTE CORONARY SYNDROME)

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

WHO-VATC

QB01AC24

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

NCI_THESAURUS

C80483

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

NDF-RT

N0000182142

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

EMA ASSESSMENT REPORTS

BRILIQUE (AUTHORIZED:ACUTE CORONARY SYNDROME)

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

LIVERTOX

NBK548529

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

Code System Code Type Description

MERCK INDEX

m10853

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

Merck Index

NCI_THESAURUS

C76404

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

RS_ITEM_NUM

1667177

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

DRUG CENTRAL

4184

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

RXCUI

1116632

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

RxNorm

MESH

C503700

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

INN

8772

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

SMS_ID

100000115464

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

LACTMED

Ticagrelor

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

CAS

274693-27-5

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

NDF-RT

N0000182141

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

Cytochrome P450 3A4 Inhibitors [MoA]

EPA CompTox

DTXSID901009337

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

ChEMBL

CHEMBL398435

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

NDF-RT

N0000190482

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

Phenylalanine Hydroxylase Activators [MoA]

PUBCHEM

9871419

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

NDF-RT

N0000185503

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

P-Glycoprotein Inhibitors [MoA]

HSDB

8306

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

NDF-RT

N0000182143

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

P2Y12 Receptor Antagonists [MoA]

CHEBI

68558

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

WIKIPEDIA

Ticagrelor

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

DRUG BANK

DB08816

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

USAN

TT-94

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

EVMPD

SUB30898

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

FDA UNII

GLH0314RVC

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

IUPHAR

1765

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

NDF-RT

N0000190115

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

Cytochrome P450 3A5 Inhibitors [MoA]

DAILYMED

GLH0314RVC

Created by admin on Fri Dec 15 16:04:37 UTC 2023 , Edited by admin on Fri Dec 15 16:04:37 UTC 2023

PRIMARY

Related Record Type Details


					0UZ317Q903

TICAGRELOR MONOHYDRATE

SALT/SOLVATE -> PARENT


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE


					1TBM83QR9S

INHIBITOR -> TARGET

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> INHIBITOR

Interaction Type:

WEAK


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> INHIBITOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					0UZ317Q903

TICAGRELOR MONOHYDRATE

SOLVATE->ANHYDROUS


					O0QUP6NQ1H

P2Y PURINOCEPTOR 12

TARGET -> INHIBITOR

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE

Related Record Type Details


					LNY396KYTZ

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

URINE

Related Record Type Details


					GLH0314RVC

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC

Tmax	PHARMACOKINETIC