PRACINOSTAT

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H30N4O2
Molecular Weight	358.4778
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of PRACINOSTAT

Structure Search

SMILES

CCCCC1=NC2=CC(\C=C\C(=O)NO)=CC=C2N1CCN(CC)CC

InChI

InChIKey=JHDKZFFAIZKUCU-ZRDIBKRKSA-N

InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+

HIDE SMILES / InChI

Molecular Formula	C20H30N4O2
Molecular Weight	358.4778
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:21:20 UTC 2023` Edited by `admin` on `Fri Dec 15 17:21:20 UTC 2023`
Record UNII	GPO2JN4UON
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PRACINOSTAT

Official Name

English

SB-939

Code

English

Pracinostat [WHO-DD]

Common Name

English

SB939

Common Name

English

SB 939

Code

English

KAEMPFEROL 3-O-.BETA.-D-(6-E-P-COUMAROYLGLUCOSIDE)

Common Name

English

(2E)-3-(2-BUTYL-1-(2-(DIMETHYLAMINO)ETHYL)-1H-BENZIMIDAZOL-5-YL)-N-HYDROXYPROP-2-ENAMIDE

Systematic Name

English

pracinostat [INN]

Common Name

English

(E)-3-(2-BUTYL-1-(2-DIETHYLAMINOETHYL)-1H-BENZIMIDAZOL-5-YL)-N-HYDROXY-2-PROPENAMIDE

Systematic Name

English

2-PROPENAMIDE, 3-(2-BUTYL-1-(2-(DIETHYLAMINO)ETHYL)-1H-BENZIMIDAZOL-5-YL)-N-HYDROXY-, (2E)-

Systematic Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

421313

Created by admin on Fri Dec 15 17:21:20 UTC 2023 , Edited by admin on Fri Dec 15 17:21:20 UTC 2023

NCI_THESAURUS

C1946

Created by admin on Fri Dec 15 17:21:20 UTC 2023 , Edited by admin on Fri Dec 15 17:21:20 UTC 2023

EU-Orphan Drug

EU/3/17/1927

Created by admin on Fri Dec 15 17:21:20 UTC 2023 , Edited by admin on Fri Dec 15 17:21:20 UTC 2023

Code System Code Type Description

NCI_THESAURUS

C71708

Created by admin on Fri Dec 15 17:21:20 UTC 2023 , Edited by admin on Fri Dec 15 17:21:20 UTC 2023

PRIMARY

PUBCHEM

49855250

Created by admin on Fri Dec 15 17:21:20 UTC 2023 , Edited by admin on Fri Dec 15 17:21:20 UTC 2023

PRIMARY

CHEBI

95071

Created by admin on Fri Dec 15 17:21:20 UTC 2023 , Edited by admin on Fri Dec 15 17:21:20 UTC 2023

PRIMARY

CAS

929016-96-6

Created by admin on Fri Dec 15 17:21:20 UTC 2023 , Edited by admin on Fri Dec 15 17:21:20 UTC 2023

PRIMARY

FDA UNII

GPO2JN4UON

Created by admin on Fri Dec 15 17:21:20 UTC 2023 , Edited by admin on Fri Dec 15 17:21:20 UTC 2023

PRIMARY

DRUG BANK

DB05223

Created by admin on Fri Dec 15 17:21:20 UTC 2023 , Edited by admin on Fri Dec 15 17:21:20 UTC 2023

PRIMARY

INN

9386

Created by admin on Fri Dec 15 17:21:20 UTC 2023 , Edited by admin on Fri Dec 15 17:21:20 UTC 2023

PRIMARY

EPA CompTox

DTXSID00239196

Created by admin on Fri Dec 15 17:21:20 UTC 2023 , Edited by admin on Fri Dec 15 17:21:20 UTC 2023

PRIMARY

WIKIPEDIA

Pracinostat

Created by admin on Fri Dec 15 17:21:20 UTC 2023 , Edited by admin on Fri Dec 15 17:21:20 UTC 2023

PRIMARY

SMS_ID

100000174901

Created by admin on Fri Dec 15 17:21:20 UTC 2023 , Edited by admin on Fri Dec 15 17:21:20 UTC 2023

PRIMARY

Related Record Type Details


					O037NFL7YQ

HISTONE DEACETYLASE 1

TARGET -> INHIBITOR


					VK4SQL11C0

CYTOCHROME P450 1A2

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

MAJOR


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

MAJOR

Related Record Type Details


					APT88E0NAJ

2-PROPENOIC ACID, 3-(2-BUTYL-1-(2-(DIETHYLAMINO)ETHYL)-1H-BENZIMIDAZOL-5-YL)-, (2E)-

METABOLITE -> PARENT


					5CN8Z912E1

2-PROPENAMIDE, 3-(1-(2-AMINOETHYL)-2-BUTYL-1H-BENZIMIDAZOL-5-YL)-N-HYDROXY-, (2E)-

METABOLITE -> PARENT


					9H0143U14X

(2E)-3-(2-BUTYL-1-(2-(ETHYLAMINO)ETHYL)-1H-BENZIMIDAZOL-5-YL)-N-HYDROXY-2-PROPENAMIDE

METABOLITE -> PARENT

Related Record Type Details


					GPO2JN4UON

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC				ORAL SINGLE DOSE ADMINISTRATION

Tmax	PHARMACOKINETIC				ORAL SINGLE DOSE ADMINISTRATION

blood-toplasma ratio	PHARMACOKINETIC