U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C38H69NO13
Molecular Weight 747.9534
Optical Activity UNSPECIFIED
Defined Stereocenters 18 / 18
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLARITHROMYCIN

SMILES

[H][C@@]2(O[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@]([H])(O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@H]2C

InChI

InChIKey=AGOYDEPGAOXOCK-KCBOHYOISA-N
InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1

HIDE SMILES / InChI
Molecular Formula C38H69NO13
Molecular Weight 747.9534
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 18 / 18
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:53:15 UTC 2023
Edited
by admin
on Fri Dec 15 15:53:15 UTC 2023
Record UNII
H1250JIK0A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CLARITHROMYCIN
EP   INN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
CLARITHROMYCIN [MI]
Common Name English
6-O-Methylerythromycin
Common Name English
CLARITHROMYCIN [MART.]
Common Name English
NAXY
Brand Name English
CLARITHROMYCIN COMPONENT OF PREVPAC
Common Name English
Clarithromycin [WHO-DD]
Common Name English
CLARITHROMYCIN IDENTITY [USP-RS]
Common Name English
CLARITHROMYCIN [USP MONOGRAPH]
Common Name English
clarithromycin [INN]
Common Name English
PREVPAC COMPONENT CLARITHROMYCIN
Common Name English
BIAXIN
Brand Name English
CLAROSIP
Brand Name English
ABBOTT-56268
Code English
MACLADIN
Brand Name English
KLARICID
Brand Name English
CLARITHROMYCIN [EP MONOGRAPH]
Common Name English
ZECLAR
Brand Name English
TE-031
Code English
VECLAM
Brand Name English
CLARITHROMYCIN [VANDF]
Common Name English
CYLLIND
Brand Name English
A-56268
Code English
NSC-758704
Code English
CLARITHROMYCIN [JAN]
Common Name English
MAVID
Brand Name English
CLARITHROMYCIN IDENTITY
USP-RS  
Common Name English
ERYTHROMYCIN, 6-O-METHYL-
Common Name English
CLARITHROMYCIN [USP-RS]
Common Name English
CLARITHROMYCIN [USP IMPURITY]
Common Name English
KLACID
Brand Name English
CLARITHROMYCIN [ORANGE BOOK]
Common Name English
Classification Tree Code System Code
WHO-ATC A02BD09
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
WHO-ATC A02BD07
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
WHO-VATC QA02BD05
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
FDA ORPHAN DRUG 770820
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
WHO-VATC QJ01FA09
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
NDF-RT N0000007529
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
WHO-VATC QA02BD04
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
WHO-ATC J01FA09
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
WHO-ESSENTIAL MEDICINES LIST 6.2.2
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
NDF-RT N0000007529
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
FDA ORPHAN DRUG 338811
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
NDF-RT N0000007529
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
LIVERTOX NBK547886
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
WHO-ATC A02BD05
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
WHO-ATC A02BD06
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
WHO-VATC QA02BD06
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
NDF-RT N0000175935
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
WHO-VATC QA02BD07
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
WHO-ATC A02BD04
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
WHO-ATC A02BD11
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
NCI_THESAURUS C261
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
Code System Code Type Description
MERCK INDEX
m3608
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY Merck Index
NDF-RT
N0000190114
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY Cytochrome P450 3A Inhibitors [MoA]
NDF-RT
N0000182141
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY Cytochrome P450 3A4 Inhibitors [MoA]
HSDB
8055
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
USAN
Y-76
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
CHEBI
3732
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
ChEMBL
CHEMBL1741
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
NDF-RT
N0000185503
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY P-Glycoprotein Inhibitors [MoA]
CAS
81103-11-9
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
DRUG BANK
DB01211
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
EPA CompTox
DTXSID3022829
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
NCI_THESAURUS
C1054
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
INN
6252
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
FDA UNII
H1250JIK0A
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
LACTMED
Clarithromycin
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
RS_ITEM_NUM
1134379
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
WIKIPEDIA
CLARITHROMYCIN
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
NSC
758704
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
RXCUI
21212
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY RxNorm
DAILYMED
H1250JIK0A
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
SMS_ID
100000092364
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
DRUG CENTRAL
668
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
EVMPD
SUB06641MIG
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
MESH
D017291
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
PUBCHEM
84029
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
PRIMARY
RS_ITEM_NUM
1134390
Created by admin on Fri Dec 15 15:53:15 UTC 2023 , Edited by admin on Fri Dec 15 15:53:15 UTC 2023
ALTERNATIVE
Related Record Type Details
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> INHIBITOR
CYTOCHROME P450 3A4
METABOLIC ENZYME -> INDUCER
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
MYCOPLASMA FERMENTANS
TARGET ORGANISM->INHIBITOR
18 STRAINS; LESS THE 8 ng/mL for some strains; MIC range listed
MIC90
CYTOCHROME P450 3A4
METABOLIC ENZYME -> INHIBITOR
POTENT
Related Record Type Details
Structure of 14-HYDROXYCLARITHROMYCIN
METABOLITE ACTIVE -> PARENT
14-Clarithromycin is less active than the parent molecule.
Related Record Type Details
Structure of 6,12-Di-O-methylerythromycin
IMPURITY -> PARENT
Structure of ERYTHROMYCIN, N-DEMETHYL-6-O-METHYL-
IMPURITY -> PARENT
Related Record Type Details
Structure of CLARITHROMYCIN
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MIC BIOLOGICAL SUSCEPTIBILITY: RESISTANT

PATHOGEN: H. INFLUENZAE

Biological Half-life PHARMACOKINETIC 14-OH-CLARITHROMYCIN

MIC BIOLOGICAL SUSCEPTIBILITY: SUSCEPTIBLE

PATHOGEN: S. AUREUS

Tmax PHARMACOKINETIC FORMULATION: EXTENDED RELEASE

MIC BIOLOGICAL SUSCEPTIBILITY: RESISTANT

PATHOGEN: S. PYOGENES, S. PNEUMONIAE, H. PYLORI

MIC BIOLOGICAL SUSCEPTIBILITY: INTERMEDIATE

PATHOGEN: H. INFLUENZAE

MIC BIOLOGICAL SUSCEPTIBILITY: INTERMEDIATE

PATHOGEN: S. AUREUS

MIC BIOLOGICAL SUSCEPTIBILITY: INTERMEDIATE

PATHOGEN: S. PYOGENES, S. PNEUMONIAE

MIC BIOLOGICAL PATHOGEN: S. PYOGENES, S. PNEUMONIAE, H. PYLORI

SUSCEPTIBILITY: SUSCEPTIBLE

ORAL BIOAVAILABILITY PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC
Tmax PHARMACOKINETIC FORMULATION: IMMEDIATE RELEASE

MIC BIOLOGICAL PATHOGEN: S. AUREUS

SUSCEPTIBILITY: RESISTANT

MIC BIOLOGICAL SUSCEPTIBILITY: SUSCEPTIBLE

PATHOGEN: H. INFLUENZAE

NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966