STAUROSPORINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C28H26N4O3
Molecular Weight	466.531
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of STAUROSPORINE

Structure Search

SMILES

[H][C@]12C[C@@H](NC)[C@@H](OC)[C@](C)(O1)N3C4=C(C=CC=C4)C5=C3C6=C(C7=CC=CC=C7N26)C8=C5CNC8=O

InChI

InChIKey=HKSZLNNOFSGOKW-FYTWVXJKSA-N

InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C28H26N4O3
Molecular Weight	466.531
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:41:46 UTC 2023` Edited by `admin` on `Fri Dec 15 19:41:46 UTC 2023`
Record UNII	H88EPA0A3N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

STAUROSPORINE

Common Name

English

CGP-39360

Code

English

STAUROSPORIN

Common Name

English

STAUROSPORINE [MI]

Common Name

English

(9S,10R,11R,13R)- 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO(1,2,3-GH:3',2',1'-LM)PYRROLO(3,4-J)(1,7)BENZODIAZONIN-1-ONE

Common Name

English

(+)-STAUROSPORINE

Common Name

English

AM-2282

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C1404

Created by admin on Fri Dec 15 19:41:47 UTC 2023 , Edited by admin on Fri Dec 15 19:41:47 UTC 2023

NCI_THESAURUS

C221

Created by admin on Fri Dec 15 19:41:47 UTC 2023 , Edited by admin on Fri Dec 15 19:41:47 UTC 2023

Code System Code Type Description

FDA UNII

H88EPA0A3N

Created by admin on Fri Dec 15 19:41:47 UTC 2023 , Edited by admin on Fri Dec 15 19:41:47 UTC 2023

PRIMARY

WIKIPEDIA

Staurosporine

Created by admin on Fri Dec 15 19:41:47 UTC 2023 , Edited by admin on Fri Dec 15 19:41:47 UTC 2023

PRIMARY

DRUG BANK

DB02010

Created by admin on Fri Dec 15 19:41:47 UTC 2023 , Edited by admin on Fri Dec 15 19:41:47 UTC 2023

PRIMARY

MESH

D019311

Created by admin on Fri Dec 15 19:41:47 UTC 2023 , Edited by admin on Fri Dec 15 19:41:47 UTC 2023

PRIMARY

CAS

62996-74-1

Created by admin on Fri Dec 15 19:41:47 UTC 2023 , Edited by admin on Fri Dec 15 19:41:47 UTC 2023

PRIMARY

CHEBI

57491

Created by admin on Fri Dec 15 19:41:47 UTC 2023 , Edited by admin on Fri Dec 15 19:41:47 UTC 2023

PRIMARY

PUBCHEM

44259

Created by admin on Fri Dec 15 19:41:47 UTC 2023 , Edited by admin on Fri Dec 15 19:41:47 UTC 2023

PRIMARY

EPA CompTox

DTXSID6041131

Created by admin on Fri Dec 15 19:41:47 UTC 2023 , Edited by admin on Fri Dec 15 19:41:47 UTC 2023

PRIMARY

NCI_THESAURUS

C1237

Created by admin on Fri Dec 15 19:41:47 UTC 2023 , Edited by admin on Fri Dec 15 19:41:47 UTC 2023

PRIMARY

CHEBI

15738

Created by admin on Fri Dec 15 19:41:47 UTC 2023 , Edited by admin on Fri Dec 15 19:41:47 UTC 2023

PRIMARY

MERCK INDEX

m10198

Created by admin on Fri Dec 15 19:41:47 UTC 2023 , Edited by admin on Fri Dec 15 19:41:47 UTC 2023

PRIMARY

Merck Index

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					YDL509611I

CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA

TARGET -> INHIBITOR


					143300S48F

BETA-ADRENERGIC RECEPTOR KINASE 1

TARGET -> INHIBITOR


					9LLR266790

TYROSINE-PROTEIN KINASE JAK3

TARGET -> INHIBITOR


					EL8FEW3TUM

MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE

TARGET -> INHIBITOR


					843L3OYS7O

MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5

TARGET -> INHIBITOR


					5K47RF8GE8

MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11

TARGET -> INHIBITOR


					ORH3YB25JY

SERINE/THREONINE-PROTEIN KINASE N2

TARGET -> INHIBITOR


					3AZ1VUF0Q7

MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE

TARGET -> INHIBITOR


					O2MTR8W9R0

TYROSINE-PROTEIN KINASE LCK

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					8EJE45ZR0I

TYROSINE-PROTEIN KINASE RECEPTOR UFO

TARGET -> INHIBITOR


					4CH8636GFF

INSULIN RECEPTOR

TARGET -> INHIBITOR

Comments:

Enzymatic Assay

Qualification:

IC50

Amount:


					D6NY137WFQ

MAP KINASE-ACTIVATED PROTEIN KINASE 3

TARGET -> INHIBITOR


					GL209F9TZS

TYROSINE-PROTEIN KINASE JAK2

TARGET -> INHIBITOR


					08S4A2S6FT

TYROSINE-PROTEIN KINASE JAK1

TARGET -> INHIBITOR


					KY25K9D5AA

INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON

TARGET -> INHIBITOR


					13U1W2G8EZ

EPHRIN TYPE-A RECEPTOR 3

TARGET -> INHIBITOR

Amount:


					C1P36E2V4Q

EPHRIN TYPE-B RECEPTOR 2

TARGET -> INHIBITOR


					DK566K8T76

RHO-ASSOCIATED PROTEIN KINASE 1

TARGET -> INHIBITOR


					HQ6Z0L08Y3

RIBOSOMAL PROTEIN S6 KINASE ALPHA-1

TARGET -> INHIBITOR


					W48I3O72LB

PROTEIN KINASE C ALPHA TYPE

TARGET -> INHIBITOR

Comments:

Enzymatic Assay

Qualification:

IC50

Amount:


					S276B35HIP

EPHRIN TYPE-A RECEPTOR 8

TARGET -> INHIBITOR


					727KOM8V4H

SERINE/THREONINE-PROTEIN KINASE 38

TARGET -> INHIBITOR


					6P6Y82PIL1

LEUKOCYTE TYROSINE KINASE RECEPTOR

TARGET -> INHIBITOR


					QZN6JO65KK

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV

TARGET -> INHIBITOR


					51A15DDJ1W

G PROTEIN-COUPLED RECEPTOR KINASE 5

TARGET -> INHIBITOR


					LB78KZ9G1K

STAUROSPORINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					66647LGP7Q

SERINE/THREONINE-PROTEIN KINASE D1

TARGET -> INHIBITOR

Related Record Type Details


					H88EPA0A3N

ACTIVE MOIETY

Amount: