EMPAGLIFLOZIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H27ClO7
Molecular Weight	450.909
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of EMPAGLIFLOZIN

Structure Search

SMILES

OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)C2=CC(CC3=CC=C(O[C@H]4CCOC4)C=C3)=C(Cl)C=C2

InChI

InChIKey=OBWASQILIWPZMG-QZMOQZSNSA-N

InChI=1S/C23H27ClO7/c24-18-6-3-14(23-22(28)21(27)20(26)19(11-25)31-23)10-15(18)9-13-1-4-16(5-2-13)30-17-7-8-29-12-17/h1-6,10,17,19-23,25-28H,7-9,11-12H2/t17-,19+,20+,21-,22+,23-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C23H27ClO7
Molecular Weight	450.909
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:16:23 UTC 2023` Edited by `admin` on `Fri Dec 15 19:16:23 UTC 2023`
Record UNII	HDC1R2M35U
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

EMPAGLIFLOZIN

Official Name

English

EMPAGLIFLOZIN COMPONENT OF GLYXAMBI

Brand Name

English

EMPAGLIFLOZIN [USAN]

Common Name

English

D-GLUCITOL, 1,5-ANHYDRO-1-C-(4-CHLORO-3-((4-(((3S)-TETRAHYDRO-3-FURANYL)OXY)PHENYL)METHYL)PHENYL)-, (1S)-

Common Name

English

TRIJARDY XR COMPONENT EMPAGLIFLOZIN

Brand Name

English

(1S)-1,5-ANHYDRO-1-C-(4-CHLORO-3-((4-(((3S)-OXAN-3-YL)OXY)PHENYL)METHYL)PHENYL)-D-GLUCITOL

Common Name

English

BI-10773

Code

English

EMPAGLIFLOZIN COMPONENT OF TRIJARDY XR

Brand Name

English

BI10773

Code

English

EMPAGLIFLOZIN COMPONENT OF SYNJARDY

Brand Name

English

EMPAGLIFLOZIN [JAN]

Common Name

English

EMPAGLIFLOZIN [MI]

Common Name

English

GLYXAMBI COMPONENT EMPAGLIFLOZIN

Brand Name

English

Empagliflozin [WHO-DD]

Common Name

English

JARDIANCE

Brand Name

English

EMPAGLIFLOZIN [ORANGE BOOK]

Common Name

English

empagliflozin [INN]

Common Name

English

EMPAGLIFLOZIN [VANDF]

Common Name

English

Classification Tree Code System Code

WHO-ATC

A10BD20

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

WHO-ATC

A10BD19

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

WHO-VATC

QA10BX12

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

WHO-ATC

A10BK03

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

WHO-ATC

A10BX12

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

NDF-RT

N0000187059

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

Code System Code Type Description

ChEMBL

CHEMBL2107830

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

NCI_THESAURUS

C158136

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

DRUG BANK

DB09038

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

SMS_ID

100000128629

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

EPA CompTox

DTXSID601026093

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

PUBCHEM

11949646

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

CHEBI

82720

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

EVMPD

SUB35915

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

FDA UNII

HDC1R2M35U

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

LACTMED

Empagliflozin

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

RXCUI

1545653

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

RxNorm

USAN

ZZ108

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

NDF-RT

N0000187058

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

Sodium-Glucose Transporter 2 Inhibitors [MoA]

CAS

864070-44-0

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

INN

9398

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

IUPHAR

4754

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

DRUG CENTRAL

4830

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

DAILYMED

HDC1R2M35U

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

MESH

C570240

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

MERCK INDEX

m11910

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

WIKIPEDIA

Empagliflozin

Created by admin on Fri Dec 15 19:16:23 UTC 2023 , Edited by admin on Fri Dec 15 19:16:23 UTC 2023

PRIMARY

Related Record Type Details


					S5EY2C8G0B

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A8

METABOLIC ENZYME -> SUBSTRATE


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					0M77ZW789J

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B7

METABOLIC ENZYME -> SUBSTRATE


					3318TFY23Q

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A9

METABOLIC ENZYME -> SUBSTRATE


					HDC1R2M35U

EXCRETED UNCHANGED

Comments:

A mean of 54.4% of the dose was excreted in urine and 41.2% was excreted in feces. Approximately 50% of the drug related radioactivity excreted in urine was unchanged parent (28.6%) and approximately 83% of the drug related radioactivity excreted in feces was unchanged parent (~34%).

Qualification:

URINE

Amount:


					HDC1R2M35U

EXCRETED UNCHANGED

Comments:

A mean of 54.4% of the dose was excreted in urine and 41.2% was excreted in feces. Approximately 50% of the drug related radioactivity excreted in urine was unchanged parent (28.6%) and approximately 83% of the drug related radioactivity excreted in feces was unchanged parent (~34%).

Qualification:

FECAL

Amount:


					IHQ709299P

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A3

METABOLIC ENZYME -> SUBSTRATE

Related Record Type Details


					GAJ6QB3GML

(2S,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6S)-6-(4-CHLORO-3-((4-((3S)-TETRAHYDROFURAN-3-YL)OXYPHENYL)METHYL)PHENYL)-3,4,5-TRIHYDROXY-TETRAHYDROPYRAN-2-YL)METHOXY)-3,4,5-TRIHYDROXY-TETRAHYDROPYRAN-2-CARBOXYLIC ACID

METABOLITE -> PARENT

Amount:


					2Y9V2N2EPY

(2S,3S,4S,5R)-6-((2S,3S,4R,5R,6R)-2-(4-CHLORO-3-((4-((3S)-TETRAHYDROFURAN-3-YL)OXYPHENYL)METHYL)PHENYL)-3,5-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDROPYRAN-4-YL)OXY-3,4,5-TRIHYDROXY-TETRAHYDROPYRAN-2-CARBOXYLIC ACID

METABOLITE -> PARENT

Amount:


					VPF7YG4E9B

(2S,3R,4R,5S,6R)-2-(4-CHLORO-3-((4-((1S)-3-HYDROXY-1-(HYDROXYMETHYL)PROPOXY)PHENYL)METHYL)PHENYL)-6-(HYDROXYMETHYL)TETRAHYDROPYRAN-3,4,5-TRIOL

METABOLITE -> PARENT


					QG8UC6R6QD

(2S,3S,4S,5R,6R)-6-((2S,3R,4S,5S,6R)-2-(4-CHLORO-3-((4-((3S)-TETRAHYDROFURAN-3-YL)OXYPHENYL)METHYL)PHENYL)-4,5-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDROPYRAN-3-YL)OXY-3,4,5-TRIHYDROXY-TETRAHYDROPYRAN-2-CARBOXYLIC ACID

METABOLITE -> PARENT

Related Record Type Details


					RU69F6Q4ZE

3'-EPI EMPAGLIFLOZIN

IMPURITY -> PARENT

Amount:


					7CY9RZ5RX9

(S)-3-(4-(2-CHLOROBENZYL)PHENOXY)TETRAHYDROFURAN

IMPURITY -> PARENT

Amount:


					4WR8P4HZ8G

(S)-3-(4-(5-BROMO-2-CHLOROBENZYL)PHENOXY)TETRAHYDROFURAN

IMPURITY -> PARENT

Amount:

Related Record Type Details


					HDC1R2M35U

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				SINGLE DOSE ADMINISTRATION